FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W149471864> ?p ?o ?g. }

• W149471864 endingPage "52" @default.
• W149471864 startingPage "45" @default.
• W149471864 abstract "In the past few years it has become increasingly clear that the neuronal microtubular system is involved in the pathogenesis of Alzheimer neurofibrillary tangles (NFT). Electron microscopists were among the first to observe the relative paucity of microtubules in NFT-containing neurons. The microtubular system was later implicated immunochemically, based on an antiserum that cross-reacted with NFT and microtubules.1 In 1980 Eng et al.2 demonstrated that the cross-reactive element between microtubules and NFT was not the tubulin, which is the most abundant component of microtubules, because antibodies to tubulin did not cross-react with NFT. Attention turned to the microtubule-associated proteins (MAPs) which are a class of proteins that cycle with microtubules through temperature-dependent phases of polymerization/depolymerization and are morphologically associated with the microtubule system. One of the possible functions of the MAPs is to stabilize the microtubules against depolymerization3 and modulate their dynamic instability.4 Relative to other tissues the brain contains an abundance of microtubules and appears to have evolved its own system of MAPs. Brain MAPs have been divided into a high molecular weight group and a heterogeneous protein of 55–62 kDa designated tau. As seen on SDS-PAGE the high molecular weight group consists of a complex series of bands designated MAP15 and a doublet of approximately 280 kDa designated MAP2. Additional MAPs with unique tissue distributions and developmental chronologies have been described as well as “light chains” and kinases that bear a close association with those MAPs mentioned above.6 Of the various MAPs in brain, MAP2 is the most abundant." @default.
• W149471864 created "2016-06-24" @default.
• W149471864 creator A5016853030 @default.
• W149471864 creator A5084260138 @default.
• W149471864 date "1987-01-01" @default.
• W149471864 modified "2023-10-14" @default.
• W149471864 title "Cloning of Neurofibrillary Tangle-Related Genes" @default.
• W149471864 cites W1611407165 @default.
• W149471864 cites W1780336900 @default.
• W149471864 cites W1825655443 @default.
• W149471864 cites W1863222819 @default.
• W149471864 cites W1975652386 @default.
• W149471864 cites W1981050556 @default.
• W149471864 cites W1983763790 @default.
• W149471864 cites W1987865710 @default.
• W149471864 cites W1994030229 @default.
• W149471864 cites W1995420892 @default.
• W149471864 cites W1999257520 @default.
• W149471864 cites W2012847227 @default.
• W149471864 cites W2013475161 @default.
• W149471864 cites W2019721152 @default.
• W149471864 cites W2034214469 @default.
• W149471864 cites W2036592944 @default.
• W149471864 cites W2036642860 @default.
• W149471864 cites W2036745486 @default.
• W149471864 cites W2037851765 @default.
• W149471864 cites W2047964353 @default.
• W149471864 cites W2053377573 @default.
• W149471864 cites W2055277461 @default.
• W149471864 cites W2056046302 @default.
• W149471864 cites W2060333964 @default.
• W149471864 cites W2060458492 @default.
• W149471864 cites W2063450941 @default.
• W149471864 cites W2073861859 @default.
• W149471864 cites W2075199998 @default.
• W149471864 cites W2080795403 @default.
• W149471864 cites W2081881251 @default.
• W149471864 cites W2081945188 @default.
• W149471864 cites W2087449146 @default.
• W149471864 cites W2091239909 @default.
• W149471864 cites W2091505182 @default.
• W149471864 cites W2093256659 @default.
• W149471864 cites W2137238818 @default.
• W149471864 cites W2144779802 @default.
• W149471864 cites W2144925005 @default.
• W149471864 cites W2159159780 @default.
• W149471864 cites W2159913935 @default.
• W149471864 cites W2163403006 @default.
• W149471864 cites W2587196717 @default.
• W149471864 doi "https://doi.org/10.1007/978-1-4613-1657-2_4" @default.
• W149471864 hasPublicationYear "1987" @default.
• W149471864 type Work @default.
• W149471864 sameAs 149471864 @default.
• W149471864 citedByCount "1" @default.
• W149471864 crossrefType "book-chapter" @default.
• W149471864 hasAuthorship W149471864A5016853030 @default.
• W149471864 hasAuthorship W149471864A5084260138 @default.
• W149471864 hasConcept C121050878 @default.
• W149471864 hasConcept C142669718 @default.
• W149471864 hasConcept C142724271 @default.
• W149471864 hasConcept C1491633281 @default.
• W149471864 hasConcept C177738377 @default.
• W149471864 hasConcept C178790620 @default.
• W149471864 hasConcept C185592680 @default.
• W149471864 hasConcept C199360897 @default.
• W149471864 hasConcept C202444582 @default.
• W149471864 hasConcept C20418707 @default.
• W149471864 hasConcept C2778670691 @default.
• W149471864 hasConcept C2779134260 @default.
• W149471864 hasConcept C2779721402 @default.
• W149471864 hasConcept C33923547 @default.
• W149471864 hasConcept C41008148 @default.
• W149471864 hasConcept C49852136 @default.
• W149471864 hasConcept C502032728 @default.
• W149471864 hasConcept C55493867 @default.
• W149471864 hasConcept C61081601 @default.
• W149471864 hasConcept C68026918 @default.
• W149471864 hasConcept C71924100 @default.
• W149471864 hasConcept C84425145 @default.
• W149471864 hasConcept C86803240 @default.
• W149471864 hasConcept C95444343 @default.
• W149471864 hasConceptScore W149471864C121050878 @default.
• W149471864 hasConceptScore W149471864C142669718 @default.
• W149471864 hasConceptScore W149471864C142724271 @default.
• W149471864 hasConceptScore W149471864C1491633281 @default.
• W149471864 hasConceptScore W149471864C177738377 @default.
• W149471864 hasConceptScore W149471864C178790620 @default.
• W149471864 hasConceptScore W149471864C185592680 @default.
• W149471864 hasConceptScore W149471864C199360897 @default.
• W149471864 hasConceptScore W149471864C202444582 @default.
• W149471864 hasConceptScore W149471864C20418707 @default.
• W149471864 hasConceptScore W149471864C2778670691 @default.
• W149471864 hasConceptScore W149471864C2779134260 @default.
• W149471864 hasConceptScore W149471864C2779721402 @default.
• W149471864 hasConceptScore W149471864C33923547 @default.
• W149471864 hasConceptScore W149471864C41008148 @default.
• W149471864 hasConceptScore W149471864C49852136 @default.
• W149471864 hasConceptScore W149471864C502032728 @default.

• next