FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1494972817> ?p ?o ?g. }

• W1494972817 endingPage "23733" @default.
• W1494972817 startingPage "23728" @default.
• W1494972817 abstract "Recent studies on the tissue distribution and developmental regulation of adenosine deaminase (ADA) activity in mice show that very high ADA levels exist in the murine alimentary tract (tongue, esophagus, forestomach, proximal small intestine) and at the fetal-maternal interface. To understand the role of ADA in these tissues, we measured the levels of three other enzymes involved in purine catabolism, purine nucleoside phosphorylase (PNP), guanine deaminase (GDA), and xanthine dehydrogenase (XDH), to see how their levels correlated with ADA activity. Our results show that the highest level of PNP, GDA, and XDH is present in the proximal small intestine. Levels of these purine catabolic enzymes are much lower in the tongue, esophagus, forestomach, and fetal-maternal interface in marked contrast to ADA distribution. We also determined mRNA levels encoding PNP, XDH, and ADA in a variety of tissues. Tissue-specific differences in PNP, XDH, and ADA activity correlated with RNA abundance, indicating that the regulation of gene expression is at the level of mRNA production. Thus, ADA is part of a purine catabolic pathway leading to the production of uric acid that is present at the highest known level in the proximal small intestine. ADA may have additional roles in other tissues." @default.
• W1494972817 created "2016-06-24" @default.
• W1494972817 creator A5008276506 @default.
• W1494972817 creator A5027893444 @default.
• W1494972817 creator A5039325266 @default.
• W1494972817 creator A5087929516 @default.
• W1494972817 date "1993-11-01" @default.
• W1494972817 modified "2023-10-03" @default.
• W1494972817 title "The highest levels of purine catabolic enzymes in mice are present in the proximal small intestine." @default.
• W1494972817 cites W122515665 @default.
• W1494972817 cites W149283267 @default.
• W1494972817 cites W1513969749 @default.
• W1494972817 cites W1522328415 @default.
• W1494972817 cites W1529012886 @default.
• W1494972817 cites W1568002412 @default.
• W1494972817 cites W1581567789 @default.
• W1494972817 cites W1632628366 @default.
• W1494972817 cites W1680799029 @default.
• W1494972817 cites W16913684 @default.
• W1494972817 cites W1747820606 @default.
• W1494972817 cites W1965504294 @default.
• W1494972817 cites W1974721354 @default.
• W1494972817 cites W1978547902 @default.
• W1494972817 cites W1982522925 @default.
• W1494972817 cites W1983559242 @default.
• W1494972817 cites W1985975073 @default.
• W1494972817 cites W1986420231 @default.
• W1494972817 cites W1990632327 @default.
• W1494972817 cites W1990647203 @default.
• W1494972817 cites W1994203510 @default.
• W1494972817 cites W1999225169 @default.
• W1494972817 cites W2003437645 @default.
• W1494972817 cites W2003903343 @default.
• W1494972817 cites W2005527892 @default.
• W1494972817 cites W2007693476 @default.
• W1494972817 cites W2019410656 @default.
• W1494972817 cites W2021838114 @default.
• W1494972817 cites W2025372788 @default.
• W1494972817 cites W2026851690 @default.
• W1494972817 cites W2042139818 @default.
• W1494972817 cites W2052389457 @default.
• W1494972817 cites W2056832036 @default.
• W1494972817 cites W2058757767 @default.
• W1494972817 cites W2059915663 @default.
• W1494972817 cites W2070590243 @default.
• W1494972817 cites W2073257205 @default.
• W1494972817 cites W2086967977 @default.
• W1494972817 cites W2092315616 @default.
• W1494972817 cites W2093883210 @default.
• W1494972817 cites W2151723143 @default.
• W1494972817 cites W2160544953 @default.
• W1494972817 cites W2163271225 @default.
• W1494972817 cites W2170840709 @default.
• W1494972817 cites W2224929038 @default.
• W1494972817 cites W2335468823 @default.
• W1494972817 cites W2414137730 @default.
• W1494972817 cites W2417913690 @default.
• W1494972817 cites W2418790548 @default.
• W1494972817 cites W4293247451 @default.
• W1494972817 cites W80158289 @default.
• W1494972817 doi "https://doi.org/10.1016/s0021-9258(19)49521-5" @default.
• W1494972817 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8226898" @default.
• W1494972817 hasPublicationYear "1993" @default.
• W1494972817 type Work @default.
• W1494972817 sameAs 1494972817 @default.
• W1494972817 citedByCount "50" @default.
• W1494972817 countsByYear W14949728172012 @default.
• W1494972817 countsByYear W14949728172013 @default.
• W1494972817 countsByYear W14949728172014 @default.
• W1494972817 countsByYear W14949728172018 @default.
• W1494972817 countsByYear W14949728172019 @default.
• W1494972817 countsByYear W14949728172020 @default.
• W1494972817 countsByYear W14949728172021 @default.
• W1494972817 countsByYear W14949728172023 @default.
• W1494972817 crossrefType "journal-article" @default.
• W1494972817 hasAuthorship W1494972817A5008276506 @default.
• W1494972817 hasAuthorship W1494972817A5027893444 @default.
• W1494972817 hasAuthorship W1494972817A5039325266 @default.
• W1494972817 hasAuthorship W1494972817A5087929516 @default.
• W1494972817 hasBestOaLocation W14949728171 @default.
• W1494972817 hasConcept C169586020 @default.
• W1494972817 hasConcept C181199279 @default.
• W1494972817 hasConcept C185592680 @default.
• W1494972817 hasConcept C2776476023 @default.
• W1494972817 hasConcept C2777882243 @default.
• W1494972817 hasConcept C55493867 @default.
• W1494972817 hasConcept C86803240 @default.
• W1494972817 hasConcept C96942376 @default.
• W1494972817 hasConceptScore W1494972817C169586020 @default.
• W1494972817 hasConceptScore W1494972817C181199279 @default.
• W1494972817 hasConceptScore W1494972817C185592680 @default.
• W1494972817 hasConceptScore W1494972817C2776476023 @default.
• W1494972817 hasConceptScore W1494972817C2777882243 @default.
• W1494972817 hasConceptScore W1494972817C55493867 @default.
• W1494972817 hasConceptScore W1494972817C86803240 @default.
• W1494972817 hasConceptScore W1494972817C96942376 @default.
• W1494972817 hasIssue "31" @default.
• W1494972817 hasLocation W14949728171 @default.

• next