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- W1494996948 endingPage "68" @default.
- W1494996948 startingPage "55" @default.
- W1494996948 abstract "Although the liver has long been considered as a main organ responsible for drug metabolism, the role of the gut metabolizing enzymes and the gut microflora is becoming more profoundly evident in drug metabolism, absorption and overall efficacy. This review will explore various mechanisms by which the gut-microflora influences drug pharmacokinetics including biotransformation, bioactivation, and biodegradation as well as up- or down-regulation of the epithelial transporters. The gut-luminal fluids, intestinal mucosa and gut microflora contain high concentrations of various enzymes which are responsible for the oxidation, hydrolysis and conjugation of drugs. Such metabolic reactions may lead to either drug over- or under-dosing, which impacts the drugs efficacy and safety. The processes, by which the intestinal enzymes and gut-protein transporters influence drug pharmacokinetic parameters, will be detailed. Since the intestinal microflora plays an important role in physiological, nutritional, metabolic, and immunological processes in human body, there is currently some interest in the manipulation of its composition and activity by administering probiotics. This review will also examine the capacity of probiotics to interact with resident microbial community, affecting the respective enzymes or by providing their own specific enzymatic activities that may consequently change the bioavailability and pharmacological activity of concomitantly taken drugs." @default.
- W1494996948 created "2016-06-24" @default.
- W1494996948 creator A5018215833 @default.
- W1494996948 creator A5026540507 @default.
- W1494996948 creator A5038863854 @default.
- W1494996948 creator A5085699703 @default.
- W1494996948 date "2014-01-01" @default.
- W1494996948 modified "2023-09-26" @default.
- W1494996948 title "The Influence of Intestinal Tract and Probiotics on the Fate of Orally Administered Drugs." @default.
- W1494996948 cites W1504028930 @default.
- W1494996948 cites W1531920134 @default.
- W1494996948 cites W153858581 @default.
- W1494996948 cites W1597214954 @default.
- W1494996948 cites W1838437423 @default.
- W1494996948 cites W1867086292 @default.
- W1494996948 cites W1886861425 @default.
- W1494996948 cites W1893993890 @default.
- W1494996948 cites W1907775504 @default.
- W1494996948 cites W1964026490 @default.
- W1494996948 cites W1965486060 @default.
- W1494996948 cites W1968611253 @default.
- W1494996948 cites W1969614033 @default.
- W1494996948 cites W1972562848 @default.
- W1494996948 cites W1972815158 @default.
- W1494996948 cites W1973692138 @default.
- W1494996948 cites W1975167841 @default.
- W1494996948 cites W1975467646 @default.
- W1494996948 cites W1975959081 @default.
- W1494996948 cites W1976647838 @default.
- W1494996948 cites W1980510434 @default.
- W1494996948 cites W1983132156 @default.
- W1494996948 cites W1995688013 @default.
- W1494996948 cites W2000578179 @default.
- W1494996948 cites W2002361935 @default.
- W1494996948 cites W2005328285 @default.
- W1494996948 cites W2007352430 @default.
- W1494996948 cites W2008622864 @default.
- W1494996948 cites W2010149962 @default.
- W1494996948 cites W2010360751 @default.
- W1494996948 cites W2016848332 @default.
- W1494996948 cites W2018359273 @default.
- W1494996948 cites W2018872538 @default.
- W1494996948 cites W2022435477 @default.
- W1494996948 cites W2028402416 @default.
- W1494996948 cites W2030193124 @default.
- W1494996948 cites W2033829415 @default.
- W1494996948 cites W2035019909 @default.
- W1494996948 cites W2036256412 @default.
- W1494996948 cites W2037029956 @default.
- W1494996948 cites W2040289230 @default.
- W1494996948 cites W2041715456 @default.
- W1494996948 cites W2043348459 @default.
- W1494996948 cites W2047600931 @default.
- W1494996948 cites W2050822595 @default.
- W1494996948 cites W2059272234 @default.
- W1494996948 cites W2060997715 @default.
- W1494996948 cites W2061389980 @default.
- W1494996948 cites W2065047396 @default.
- W1494996948 cites W207183365 @default.
- W1494996948 cites W2072922667 @default.
- W1494996948 cites W2076233570 @default.
- W1494996948 cites W2077767091 @default.
- W1494996948 cites W2079197876 @default.
- W1494996948 cites W2079263137 @default.
- W1494996948 cites W2082453607 @default.
- W1494996948 cites W2083212229 @default.
- W1494996948 cites W2083323027 @default.
- W1494996948 cites W2086760913 @default.
- W1494996948 cites W2086986150 @default.
- W1494996948 cites W2095654193 @default.
- W1494996948 cites W2101450120 @default.
- W1494996948 cites W2104447659 @default.
- W1494996948 cites W2105795671 @default.
- W1494996948 cites W2106192857 @default.
- W1494996948 cites W2107567029 @default.
- W1494996948 cites W2108195091 @default.
- W1494996948 cites W2110235509 @default.
- W1494996948 cites W2111021589 @default.
- W1494996948 cites W2112535784 @default.
- W1494996948 cites W2112972569 @default.
- W1494996948 cites W2116844657 @default.
- W1494996948 cites W2118915258 @default.
- W1494996948 cites W2119373372 @default.
- W1494996948 cites W2122446900 @default.
- W1494996948 cites W2128873562 @default.
- W1494996948 cites W2129819819 @default.
- W1494996948 cites W2130034040 @default.
- W1494996948 cites W2132179124 @default.
- W1494996948 cites W2135087037 @default.
- W1494996948 cites W2137207669 @default.
- W1494996948 cites W2138546203 @default.
- W1494996948 cites W2139072294 @default.
- W1494996948 cites W2139621053 @default.
- W1494996948 cites W2142785321 @default.
- W1494996948 cites W2143339749 @default.
- W1494996948 cites W2143697555 @default.
- W1494996948 cites W2145680826 @default.
- W1494996948 cites W2146305537 @default.