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• W1495003306 abstract "Abstract Cortical spreading depression (CSD) is characterized by slowly propagating waves of neuronal/astrocytic depolarization and metabolic changes, followed by a period of quiescent neuronal and electroencephalographic activity. CSD acts as a preconditioning stimulus in brain, reducing cell death when elicited up to several days prior to an ischemic insult. Precise mechanisms associated with this neuroprotection are not known, although CSD increases the expression of a number of potentially neuroprotective genes/proteins. The nitric oxide (NO) system may be of particular importance, as it is acutely activated and chronically up‐regulated in cerebral cortex by CSD, and NO can ameliorate and exacerbate cell death under different conditions. Several molecules have recently been identified that modulate the production and/or cellular actions of NO, but it is not known whether their expression is altered by CSD. Therefore, the present study examined the effect of CSD on the spatiotemporal expression of PIN, CAPON, PSD‐95, Mn‐SOD and Cu/Zn‐SOD mRNA in the rat brain. In situ hybridization using specific [ 35 S]‐labelled oligonucleotides revealed that levels of PIN mRNA were significantly increased in the cortex and claustrum (∼30–180%; p ≤ 0.01) after 6 h and 1 and 2 days, but were again equivalent to contralateral (control) cortical values at 7, 14 and 28 days. CAPON mRNA levels were increased (∼30–180%; p ≤ 0.05) in the ipsilateral cortical hemisphere at 6 h and 2 days post treatment, but not at the other times examined. In contrast, levels of PSD‐95, Mn‐ and Cu/Zn‐SOD mRNA were not altered at any time after CSD. These results suggest that following CSD, nNOS activity and NO levels may be tightly regulated by both transcriptional and translational alterations in a range of nNOS adaptor proteins, which may contribute to CSD‐induced neuroprotection against subsequent ischemia." @default.
• W1495003306 created "2016-06-24" @default.
• W1495003306 creator A5012146179 @default.
• W1495003306 creator A5021467089 @default.
• W1495003306 creator A5055012143 @default.
• W1495003306 date "2003-12-01" @default.
• W1495003306 modified "2023-10-16" @default.
• W1495003306 title "Neuronal-NOS adaptor protein expression after spreading depression: implications for NO production and ischemic tolerance" @default.
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• W1495003306 doi "https://doi.org/10.1046/j.1471-4159.2003.02099.x" @default.
• W1495003306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14713293" @default.
• W1495003306 hasPublicationYear "2003" @default.
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