Matches in SemOpenAlex for { <https://semopenalex.org/work/W1495164085> ?p ?o ?g. }
- W1495164085 endingPage "46" @default.
- W1495164085 startingPage "34" @default.
- W1495164085 abstract "Human trials have demonstrated the feasibility of alginate-encapsulated islet cells for the treatment of type 1 diabetes. Encapsulated islets can be protected from the host's immune system and remain viable and functional following transplantation. However, the long-term success of these therapies requires that alginate microcapsules maintain their immunoprotective capacity and stability in vivo for sustained periods. In part, as a consequence of different encapsulation strategies, islet encapsulation studies have produced inconsistent results in regard to graft functioning time, stability, and overall metabolic benefits. Alginate composition (proportion of M- and G-blocks), alginate purity, the cross-linking ions (calcium or barium), and the presence or absence of additional polymer coating layers influence the success of cell encapsulation. This review summarizes the outcomes of long-term studies of alginate-encapsulated islet transplants in animals and humans and provides a critical discussion of the graft failure mechanisms, including issues with graft biocompatibility, transplantation site, and integrity of the encapsulated islet grafts. Strategies to improve the mechanical stability of alginate capsules and methods for monitoring graft survival and function in vivo are presented." @default.
- W1495164085 created "2016-06-24" @default.
- W1495164085 creator A5018808079 @default.
- W1495164085 creator A5070625855 @default.
- W1495164085 creator A5071516954 @default.
- W1495164085 creator A5083137675 @default.
- W1495164085 date "2016-02-01" @default.
- W1495164085 modified "2023-10-10" @default.
- W1495164085 title "Long-Term Function of Alginate-Encapsulated Islets" @default.
- W1495164085 cites W1526612207 @default.
- W1495164085 cites W1685600544 @default.
- W1495164085 cites W1964434647 @default.
- W1495164085 cites W1966644876 @default.
- W1495164085 cites W1968368826 @default.
- W1495164085 cites W1970598860 @default.
- W1495164085 cites W1976755654 @default.
- W1495164085 cites W1983270028 @default.
- W1495164085 cites W1986569217 @default.
- W1495164085 cites W1987048622 @default.
- W1495164085 cites W1988285488 @default.
- W1495164085 cites W1989426814 @default.
- W1495164085 cites W1990027389 @default.
- W1495164085 cites W1992559635 @default.
- W1495164085 cites W1994956325 @default.
- W1495164085 cites W1995934164 @default.
- W1495164085 cites W1996472206 @default.
- W1495164085 cites W1998944797 @default.
- W1495164085 cites W1999490106 @default.
- W1495164085 cites W1999496282 @default.
- W1495164085 cites W2000955386 @default.
- W1495164085 cites W2009779974 @default.
- W1495164085 cites W2010752200 @default.
- W1495164085 cites W2012601593 @default.
- W1495164085 cites W2024242125 @default.
- W1495164085 cites W2024452009 @default.
- W1495164085 cites W2027065592 @default.
- W1495164085 cites W2027566207 @default.
- W1495164085 cites W2028844217 @default.
- W1495164085 cites W2033021454 @default.
- W1495164085 cites W2033778299 @default.
- W1495164085 cites W2036087583 @default.
- W1495164085 cites W2037857020 @default.
- W1495164085 cites W2040911802 @default.
- W1495164085 cites W2041193295 @default.
- W1495164085 cites W2044441655 @default.
- W1495164085 cites W2053624707 @default.
- W1495164085 cites W2055736331 @default.
- W1495164085 cites W2055769747 @default.
- W1495164085 cites W2057238251 @default.
- W1495164085 cites W2057922472 @default.
- W1495164085 cites W2058894055 @default.
- W1495164085 cites W2066862080 @default.
- W1495164085 cites W2067741161 @default.
- W1495164085 cites W2067970451 @default.
- W1495164085 cites W2069537177 @default.
- W1495164085 cites W2071133893 @default.
- W1495164085 cites W2071470872 @default.
- W1495164085 cites W2071967690 @default.
- W1495164085 cites W2072368970 @default.
- W1495164085 cites W2076252520 @default.
- W1495164085 cites W2076818957 @default.
- W1495164085 cites W2079205627 @default.
- W1495164085 cites W2079844590 @default.
- W1495164085 cites W2080277182 @default.
- W1495164085 cites W2080806462 @default.
- W1495164085 cites W2082158677 @default.
- W1495164085 cites W2082506451 @default.
- W1495164085 cites W2084921347 @default.
- W1495164085 cites W2085701716 @default.
- W1495164085 cites W2088820078 @default.
- W1495164085 cites W2091446886 @default.
- W1495164085 cites W2092316227 @default.
- W1495164085 cites W2095724310 @default.
- W1495164085 cites W2098855695 @default.
- W1495164085 cites W2098899709 @default.
- W1495164085 cites W2110753158 @default.
- W1495164085 cites W2111365775 @default.
- W1495164085 cites W2112157846 @default.
- W1495164085 cites W2113460669 @default.
- W1495164085 cites W2117807678 @default.
- W1495164085 cites W2118077023 @default.
- W1495164085 cites W2118178280 @default.
- W1495164085 cites W2124793313 @default.
- W1495164085 cites W2128093102 @default.
- W1495164085 cites W2131489888 @default.
- W1495164085 cites W2135608449 @default.
- W1495164085 cites W2138121454 @default.
- W1495164085 cites W2143974213 @default.
- W1495164085 cites W2144795958 @default.
- W1495164085 cites W2145410626 @default.
- W1495164085 cites W2147036924 @default.
- W1495164085 cites W2154851120 @default.
- W1495164085 cites W2155723029 @default.
- W1495164085 cites W2158097065 @default.
- W1495164085 cites W2160370739 @default.
- W1495164085 cites W2168293763 @default.
- W1495164085 cites W2172019895 @default.
- W1495164085 cites W4241483792 @default.