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- W1495248959 abstract "We review in this chapter what is known about transgenerational responses (TGRs) in humans, that is, a defined exposure in one generation producing a measurable outcome in the next, unexposed generation(s). The nature of the transgenerational signalling in humans is unknown, but epigenetic inheritance is one candidate. Human studies have focused on transmission down the male line because the Russian doll nature of the female line introduces many confounding influences that are difficult to take into account statistically. We summarise the key findings from TGR studies in three populations: ancestral food supply on grandchild’s mortality rate in Överkalix in Northern Sweden, early paternal smoking on offspring body mass index in the Avon Longitudinal Study of Parents and Children (ALSPAC) in the UK, and paternal betel quid chewing on offspring metabolic syndrome risk in Taiwan. Exposure-sensitive periods in childhood and sex-specific transmissions are features that support biological rather than cultural transmission. Drawing on the results of animal experiments, we consider some possible mechanisms, including the ‘Y dipstick’ hypothesis, by which ancestral experience might impact on the health of future generations, and how these ideas can inform the design of future studies in humans." @default.
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- W1495248959 date "2013-01-01" @default.
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- W1495248959 title "The Nature of Human Transgenerational Responses" @default.
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- W1495248959 doi "https://doi.org/10.1007/978-3-642-23380-7_12" @default.
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