Matches in SemOpenAlex for { <https://semopenalex.org/work/W1495274944> ?p ?o ?g. }
- W1495274944 endingPage "7378" @default.
- W1495274944 startingPage "7365" @default.
- W1495274944 abstract "AMP-activated protein kinase (AMPK) is an important mediator in maintaining cellular energy homeostasis. AMPK is activated in response to a shortage of energy. Once activated, AMPK can promote ATP production and regulate metabolic energy. AMPK is a known target for treating metabolic syndrome and type-2 diabetes; however, recently AMPK is emerging as a possible metabolic tumor suppressor and target for cancer prevention and treatment. Recent epidemiological studies indicate that treatment with metformin, an AMPK activator reduces the incidence of cancer. In this article we review the role of AMPK in regulating inflammation, metabolism, and other regulatory processes with an emphasis on cancer, as well as, discuss the potential for targeting AMPK to treat various types of cancer. Activation of AMPK has been found to oppose tumor progression in several cancer types and offers a promising cancer therapy. This review evaluates the evidence linking AMPK with tumor suppressor function and analyzes the molecular mechanisms involved. AMPK activity opposes tumor development and progression in part by regulating inflammation and metabolism." @default.
- W1495274944 created "2016-06-24" @default.
- W1495274944 creator A5000681392 @default.
- W1495274944 creator A5032062559 @default.
- W1495274944 creator A5037773587 @default.
- W1495274944 creator A5067315531 @default.
- W1495274944 creator A5084325188 @default.
- W1495274944 date "2015-03-20" @default.
- W1495274944 modified "2023-10-18" @default.
- W1495274944 title "Targeting AMPK for cancer prevention and treatment" @default.
- W1495274944 cites W138746903 @default.
- W1495274944 cites W1490315563 @default.
- W1495274944 cites W1523693806 @default.
- W1495274944 cites W1592486733 @default.
- W1495274944 cites W1650797637 @default.
- W1495274944 cites W1884665164 @default.
- W1495274944 cites W1901739712 @default.
- W1495274944 cites W1966339676 @default.
- W1495274944 cites W1966711011 @default.
- W1495274944 cites W1967388640 @default.
- W1495274944 cites W1970023517 @default.
- W1495274944 cites W1971821779 @default.
- W1495274944 cites W1976269827 @default.
- W1495274944 cites W1976754594 @default.
- W1495274944 cites W1977394772 @default.
- W1495274944 cites W1979380712 @default.
- W1495274944 cites W1979538859 @default.
- W1495274944 cites W1981240955 @default.
- W1495274944 cites W1981970277 @default.
- W1495274944 cites W1983126920 @default.
- W1495274944 cites W1984177335 @default.
- W1495274944 cites W1986290379 @default.
- W1495274944 cites W1988339176 @default.
- W1495274944 cites W1989795792 @default.
- W1495274944 cites W1991075835 @default.
- W1495274944 cites W1991222141 @default.
- W1495274944 cites W1992211946 @default.
- W1495274944 cites W1992783368 @default.
- W1495274944 cites W2000311790 @default.
- W1495274944 cites W2000879000 @default.
- W1495274944 cites W2001568034 @default.
- W1495274944 cites W2004796949 @default.
- W1495274944 cites W2005576365 @default.
- W1495274944 cites W2005745857 @default.
- W1495274944 cites W2011177437 @default.
- W1495274944 cites W2011185738 @default.
- W1495274944 cites W2014256369 @default.
- W1495274944 cites W2015171350 @default.
- W1495274944 cites W2021433212 @default.
- W1495274944 cites W2022720370 @default.
- W1495274944 cites W2023581351 @default.
- W1495274944 cites W2023648876 @default.
- W1495274944 cites W2023947368 @default.
- W1495274944 cites W2025567696 @default.
- W1495274944 cites W2027442494 @default.
- W1495274944 cites W2029912427 @default.
- W1495274944 cites W2032667954 @default.
- W1495274944 cites W2033400446 @default.
- W1495274944 cites W2033746173 @default.
- W1495274944 cites W2035996196 @default.
- W1495274944 cites W2036062846 @default.
- W1495274944 cites W2036073861 @default.
- W1495274944 cites W2037550202 @default.
- W1495274944 cites W2040935952 @default.
- W1495274944 cites W2041163647 @default.
- W1495274944 cites W2043854938 @default.
- W1495274944 cites W2044110601 @default.
- W1495274944 cites W2046825465 @default.
- W1495274944 cites W2051905099 @default.
- W1495274944 cites W2052299248 @default.
- W1495274944 cites W2052483921 @default.
- W1495274944 cites W2053848504 @default.
- W1495274944 cites W2055496841 @default.
- W1495274944 cites W2056022625 @default.
- W1495274944 cites W2058118671 @default.
- W1495274944 cites W2059595195 @default.
- W1495274944 cites W2059642778 @default.
- W1495274944 cites W2066013672 @default.
- W1495274944 cites W2070224555 @default.
- W1495274944 cites W2071652229 @default.
- W1495274944 cites W2072362263 @default.
- W1495274944 cites W2073315259 @default.
- W1495274944 cites W2075079121 @default.
- W1495274944 cites W2076267095 @default.
- W1495274944 cites W2076908467 @default.
- W1495274944 cites W2077052405 @default.
- W1495274944 cites W2077949227 @default.
- W1495274944 cites W2078190084 @default.
- W1495274944 cites W2079580613 @default.
- W1495274944 cites W2093424705 @default.
- W1495274944 cites W2098085925 @default.
- W1495274944 cites W2098912234 @default.
- W1495274944 cites W2100889797 @default.
- W1495274944 cites W2101428185 @default.
- W1495274944 cites W2102891343 @default.
- W1495274944 cites W2102937816 @default.
- W1495274944 cites W2103450921 @default.
- W1495274944 cites W2103637700 @default.