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- W1495307542 abstract "Publisher Summary Sphingomyelin (N-acyl sphingosine phosphorylcholine, SM) is the primary sphingophospholipid in mammalian cells. As much as two-thirds of the total cellular sphingomyelin resides at the plasma membrane, where it plays important structural and functional roles. Membrane structural order, fluidity and asymmetry, cholesterol transport, esterification and de novo synthesis, and membrane vesiculation and trafficking are related to the level of SM in plasma membranes. SM is also the major source of bioactive sphingolipid second messengers, ceramide and sphingosine, which are involved in cellular responses to stress and inflammation. Although sphingomyelin turnover has been studied intensively since the mid-1980s, little is known about the enzymes that carry out its synthesis. The major pathway for the synthesis of sphingomyelin is by transfer of the phosphorylcholine group from phosphatidylcholine to ceramide, yielding diacylglycerol and sphingomyelin. This reaction is catalyzed by phosphatidylcholine ceramide cholinephosphotransferase (PC; ceramide-PCh transferase), also known as “sphingomyelin synthase.” CDP-choline can act as a phosphorylcholine donor in vitro; however, the reaction prefers an unnatural analog of ceramide in which the sphingoid base is in a threo configuration and is acylated by a short chain fatty acid." @default.
- W1495307542 created "2016-06-24" @default.
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- W1495307542 date "2000-01-01" @default.
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- W1495307542 title "[5] Assays for the biosynthesis of sphingomyelin and ceramide phosphoethanolamine" @default.
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- W1495307542 doi "https://doi.org/10.1016/s0076-6879(00)11064-x" @default.
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