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- W149534088 abstract "To determine the effect of altered membrane fluidity on platelet aggregation/agglutination, fresh, washed human platelets were treated with A2C, a cyclopropyl fatty acid ester which is known to enhance mobility of intrinsic membrane bilayer constituents and increase membrane fluidity. Fluorescence polarization studies demonstrated A2C incubation time- and concentration-dependent increases in platelet membrane fluidity (decreased fluorescence anisotropy). Preincubation with A2C was associated with diminished collagen, thrombin and ristocetin-induced platelet aggregation/agglutination. Aggregation/agglutination was diminished by 93 ± 5% for collagen (0.2 mg/ml), 53 ± 3% for thrombin (1.0 U/ml) and 85 ± 9% for ristocetin (1.1 mg/ml). These data suggest that membrane fluidity is involved in the regulation of platelet function." @default.
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- W149534088 date "1993-01-01" @default.
- W149534088 modified "2023-09-27" @default.
- W149534088 title "Lipid fluidity modulates platelet aggregation and agglutination" @default.
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- W149534088 doi "https://doi.org/10.1016/0024-3205(93)90258-5" @default.
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