Matches in SemOpenAlex for { <https://semopenalex.org/work/W1495355013> ?p ?o ?g. }
- W1495355013 endingPage "254" @default.
- W1495355013 startingPage "217" @default.
- W1495355013 abstract "Mitochondrial DNA (mtDNA) is essential for the aerobic ATP synthesis system that is responsible for about 80% of normal cellular energy demands. In addition to rare genetic disorders causing neuromyopathy, alterations of mtDNA have been found also in so‐called common diseases such as heart failure, diabetes, and cancer. Although some of these alterations are inherited, some are considered to be generated and/or accumulated in somatic cells with age. One reason for the somatic mutations is that mtDNA is more vulnerable than is nuclear DNA. For example, mitochondrial respiratory chain produces a large amount of reactive oxygen species as inevitable byproducts of oxidative phosphorylation. However, the molecular mechanisms for maintenance of mitochondrial genome are much less elucidated than those for nuclear genome. In spite of its increasing importance, the molecular diagnosis of mitochondrial DNA‐related diseases is well done only in very limited expert laboratories. In this chapter, we focus on maintenance of mtDNA in somatic cells, its clinical importance, and recent developments of molecular tests." @default.
- W1495355013 created "2016-06-24" @default.
- W1495355013 creator A5007606729 @default.
- W1495355013 creator A5048838957 @default.
- W1495355013 date "2006-01-01" @default.
- W1495355013 modified "2023-10-14" @default.
- W1495355013 title "Mitochondrial Disease: Maintenance of Mitochondrial Genome and Molecular Diagnostics" @default.
- W1495355013 cites W1480951384 @default.
- W1495355013 cites W1495843779 @default.
- W1495355013 cites W1509720837 @default.
- W1495355013 cites W1535907462 @default.
- W1495355013 cites W1548912336 @default.
- W1495355013 cites W1551996591 @default.
- W1495355013 cites W1561484646 @default.
- W1495355013 cites W1576093526 @default.
- W1495355013 cites W1579112009 @default.
- W1495355013 cites W1665535554 @default.
- W1495355013 cites W1801560648 @default.
- W1495355013 cites W1802480460 @default.
- W1495355013 cites W1862994794 @default.
- W1495355013 cites W1926649163 @default.
- W1495355013 cites W1966318682 @default.
- W1495355013 cites W1966691625 @default.
- W1495355013 cites W1966702780 @default.
- W1495355013 cites W1968144312 @default.
- W1495355013 cites W1968188575 @default.
- W1495355013 cites W1968197570 @default.
- W1495355013 cites W1970715933 @default.
- W1495355013 cites W1972140717 @default.
- W1495355013 cites W1973211255 @default.
- W1495355013 cites W1974089913 @default.
- W1495355013 cites W1976805968 @default.
- W1495355013 cites W1978675778 @default.
- W1495355013 cites W1979610420 @default.
- W1495355013 cites W1981613679 @default.
- W1495355013 cites W1987207427 @default.
- W1495355013 cites W1988888878 @default.
- W1495355013 cites W1990814134 @default.
- W1495355013 cites W1992805337 @default.
- W1495355013 cites W1993103503 @default.
- W1495355013 cites W1994527193 @default.
- W1495355013 cites W1998344938 @default.
- W1495355013 cites W2001213570 @default.
- W1495355013 cites W2006346064 @default.
- W1495355013 cites W2007635795 @default.
- W1495355013 cites W2011348831 @default.
- W1495355013 cites W2011906490 @default.
- W1495355013 cites W2014254942 @default.
- W1495355013 cites W2014415254 @default.
- W1495355013 cites W2016236490 @default.
- W1495355013 cites W2016574982 @default.
- W1495355013 cites W2017347785 @default.
- W1495355013 cites W2023154900 @default.
- W1495355013 cites W2024085208 @default.
- W1495355013 cites W2026447143 @default.
- W1495355013 cites W2029084348 @default.
- W1495355013 cites W2031077482 @default.
- W1495355013 cites W2032913442 @default.
- W1495355013 cites W2034378072 @default.
- W1495355013 cites W2035663444 @default.
- W1495355013 cites W2036351079 @default.
- W1495355013 cites W2036791811 @default.
- W1495355013 cites W2040118814 @default.
- W1495355013 cites W2041922226 @default.
- W1495355013 cites W2042138106 @default.
- W1495355013 cites W2044897807 @default.
- W1495355013 cites W2047223095 @default.
- W1495355013 cites W2047310192 @default.
- W1495355013 cites W2048446704 @default.
- W1495355013 cites W2051274874 @default.
- W1495355013 cites W2051291382 @default.
- W1495355013 cites W2051694207 @default.
- W1495355013 cites W2056088477 @default.
- W1495355013 cites W2056146464 @default.
- W1495355013 cites W2057162464 @default.
- W1495355013 cites W2057380297 @default.
- W1495355013 cites W2058753163 @default.
- W1495355013 cites W2060626022 @default.
- W1495355013 cites W2060657842 @default.
- W1495355013 cites W2062470263 @default.
- W1495355013 cites W2063562590 @default.
- W1495355013 cites W2064196612 @default.
- W1495355013 cites W2064518237 @default.
- W1495355013 cites W2069501380 @default.
- W1495355013 cites W2071887573 @default.
- W1495355013 cites W2075095457 @default.
- W1495355013 cites W2075619489 @default.
- W1495355013 cites W2075685752 @default.
- W1495355013 cites W2075835114 @default.
- W1495355013 cites W2076433667 @default.
- W1495355013 cites W2076519092 @default.
- W1495355013 cites W2077414996 @default.
- W1495355013 cites W2077517552 @default.
- W1495355013 cites W2078840215 @default.
- W1495355013 cites W2079161571 @default.
- W1495355013 cites W2081777032 @default.
- W1495355013 cites W2085752695 @default.
- W1495355013 cites W2088112980 @default.