FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1495408511> ?p ?o ?g. }

• W1495408511 endingPage "2519" @default.
• W1495408511 startingPage "2511" @default.
• W1495408511 abstract "Two dendritic cell (DC) subsets have been identified in the murine system on the basis of their differential CD8α expression. CD8α+ DCs and CD8α− DCs are considered as lymphoid- and myeloid-derived, respectively, because CD8α+ but not CD8α− splenic DCs were generated from lymphoid CD4low precursors, devoid of myeloid reconstitution potential. Although CD8α− DCs were first described as negative for CD4, our results demonstrate that approximately 70% of them are CD4+. Besides CD4− CD8α− and CD4+CD8α− DCs displayed a similar phenotype and T-cell stimulatory potential in mixed lymphocyte reaction (MLR), although among CD8α− DCs, the CD4+ subset appears to have a higher endocytic capacity. Finally, experiments of DC reconstitution after irradiation in which, in contrast to previous studies, donor-type DCs were analyzed without depleting CD4+ cells, revealed that both CD8α+ DCs and CD8α− DCs were generated after transfer of CD4low precursors. These data suggest that both CD8α+ and CD8α− DCs derive from a common precursor and, hence, do not support the concept of the CD8α+ lymphoid-derived and CD8α−myeloid-derived DC lineages. However, because this hypothesis has to be confirmed at the clonal level, it remains possible that CD8α− DCs arise from a myeloid precursor within the CD4low precursor population or, alternatively, that both CD8α+ and CD8α− DCs derive from an independent nonlymphoid, nonmyeloid DC precursor. In conclusion, although we favor the hypothesis that both CD8α+ and CD8α− DCs derive from a lymphoid-committed precursor, a precise study of the differentiation process of CD8α+ and CD8α− DCs is required to define conclusively their origin." @default.
• W1495408511 created "2016-06-24" @default.
• W1495408511 creator A5019989253 @default.
• W1495408511 creator A5055156498 @default.
• W1495408511 creator A5067127987 @default.
• W1495408511 creator A5075391534 @default.
• W1495408511 creator A5075826668 @default.
• W1495408511 creator A5077495940 @default.
• W1495408511 creator A5089223077 @default.
• W1495408511 date "2000-10-01" @default.
• W1495408511 modified "2023-10-03" @default.
• W1495408511 title "Concept of lymphoid versus myeloid dendritic cell lineages revisited: both CD8α− and CD8α+dendritic cells are generated from CD4lowlymphoid-committed precursors" @default.
• W1495408511 cites W1545564541 @default.
• W1495408511 cites W1567741823 @default.
• W1495408511 cites W1578157386 @default.
• W1495408511 cites W1893411048 @default.
• W1495408511 cites W1942198241 @default.
• W1495408511 cites W1997512963 @default.
• W1495408511 cites W2000286082 @default.
• W1495408511 cites W2005115869 @default.
• W1495408511 cites W2009404162 @default.
• W1495408511 cites W2028261045 @default.
• W1495408511 cites W2035572849 @default.
• W1495408511 cites W2080801585 @default.
• W1495408511 cites W2088024377 @default.
• W1495408511 cites W2088452990 @default.
• W1495408511 cites W2091420555 @default.
• W1495408511 cites W2095016279 @default.
• W1495408511 cites W2095666013 @default.
• W1495408511 cites W2096249856 @default.
• W1495408511 cites W2102857621 @default.
• W1495408511 cites W2105089699 @default.
• W1495408511 cites W2111570053 @default.
• W1495408511 cites W2112730454 @default.
• W1495408511 cites W2117477141 @default.
• W1495408511 cites W2128305305 @default.
• W1495408511 cites W2140944306 @default.
• W1495408511 cites W2142356948 @default.
• W1495408511 cites W2149939821 @default.
• W1495408511 cites W2155229523 @default.
• W1495408511 cites W2168774676 @default.
• W1495408511 cites W2171345725 @default.
• W1495408511 cites W2231583054 @default.
• W1495408511 cites W4237952718 @default.
• W1495408511 cites W4313335078 @default.
• W1495408511 doi "https://doi.org/10.1182/blood.v96.7.2511.h8002511_2511_2519" @default.
• W1495408511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11001905" @default.
• W1495408511 hasPublicationYear "2000" @default.
• W1495408511 type Work @default.
• W1495408511 sameAs 1495408511 @default.
• W1495408511 citedByCount "54" @default.
• W1495408511 countsByYear W14954085112012 @default.
• W1495408511 countsByYear W14954085112013 @default.
• W1495408511 countsByYear W14954085112014 @default.
• W1495408511 countsByYear W14954085112015 @default.
• W1495408511 countsByYear W14954085112016 @default.
• W1495408511 countsByYear W14954085112017 @default.
• W1495408511 countsByYear W14954085112022 @default.
• W1495408511 crossrefType "journal-article" @default.
• W1495408511 hasAuthorship W1495408511A5019989253 @default.
• W1495408511 hasAuthorship W1495408511A5055156498 @default.
• W1495408511 hasAuthorship W1495408511A5067127987 @default.
• W1495408511 hasAuthorship W1495408511A5075391534 @default.
• W1495408511 hasAuthorship W1495408511A5075826668 @default.
• W1495408511 hasAuthorship W1495408511A5077495940 @default.
• W1495408511 hasAuthorship W1495408511A5089223077 @default.
• W1495408511 hasConcept C147483822 @default.
• W1495408511 hasConcept C154317977 @default.
• W1495408511 hasConcept C167672396 @default.
• W1495408511 hasConcept C202751555 @default.
• W1495408511 hasConcept C203014093 @default.
• W1495408511 hasConcept C2778170410 @default.
• W1495408511 hasConcept C2779282312 @default.
• W1495408511 hasConcept C2908647359 @default.
• W1495408511 hasConcept C54355233 @default.
• W1495408511 hasConcept C71924100 @default.
• W1495408511 hasConcept C86803240 @default.
• W1495408511 hasConcept C95444343 @default.
• W1495408511 hasConcept C99454951 @default.
• W1495408511 hasConceptScore W1495408511C147483822 @default.
• W1495408511 hasConceptScore W1495408511C154317977 @default.
• W1495408511 hasConceptScore W1495408511C167672396 @default.
• W1495408511 hasConceptScore W1495408511C202751555 @default.
• W1495408511 hasConceptScore W1495408511C203014093 @default.
• W1495408511 hasConceptScore W1495408511C2778170410 @default.
• W1495408511 hasConceptScore W1495408511C2779282312 @default.
• W1495408511 hasConceptScore W1495408511C2908647359 @default.
• W1495408511 hasConceptScore W1495408511C54355233 @default.
• W1495408511 hasConceptScore W1495408511C71924100 @default.
• W1495408511 hasConceptScore W1495408511C86803240 @default.
• W1495408511 hasConceptScore W1495408511C95444343 @default.
• W1495408511 hasConceptScore W1495408511C99454951 @default.
• W1495408511 hasIssue "7" @default.
• W1495408511 hasLocation W14954085111 @default.
• W1495408511 hasOpenAccess W1495408511 @default.
• W1495408511 hasPrimaryLocation W14954085111 @default.
• W1495408511 hasRelatedWork W1975463463 @default.
• W1495408511 hasRelatedWork W2007093250 @default.

• next