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- W1495421875 abstract "Publisher Summary This chapter presents the overview of retrovirus, the features of the replication-incompetent retroviral system, and discusses the application of retroviral vectors to the nervous system. Retrovirus infection involves the following sequential steps: (1) entry into host cells, (2) reverse transcription, (3) integration, (4) expression of viral genes, and (5) production of viral particles. At each step, retroviruses skillfully utilize the host machinery for their propagation. Because retrovirus is infectious only to mitotic cells, the major targets in the nervous system are neural precursor (stem) cells and tumor cells. Retrovirus-mediated gene introduction can stably change the phenotypes of dividing cells and will be useful for neuronal and glial regeneration from neural precursor cells as well as for treatment of tumors. Neural precursor cells, which give rise to both neurons and glial cells, are present in the ventricular zone of the developing brain. It has been shown that these cells remain as astrocyte-like cells in the subventricular zone of the adult brain." @default.
- W1495421875 created "2016-06-24" @default.
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- W1495421875 date "2003-01-01" @default.
- W1495421875 modified "2023-09-25" @default.
- W1495421875 title "Retroviral vectors for gene delivery to neural precursor cells." @default.
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