Matches in SemOpenAlex for { <https://semopenalex.org/work/W1495424955> ?p ?o ?g. }
- W1495424955 endingPage "4555" @default.
- W1495424955 startingPage "4547" @default.
- W1495424955 abstract "Spemann's organizer has potent neural inducing and mesoderm dorsalizing activities in the Xenopus gastrula. A third activity, the organizer's ability to induce a secondary gut, has been difficult to analyze experimentally due to the lack of early gene markers. Here we introduce endodermin, a pan-endodermal gene marker, and use it to demonstrate that chordin (Chd), a protein secreted by the organizer region, is able to induce endodermal differentiation in Xenopus. The ability of chd, as well as that of noggin, to induce endoderm in animal cap explants is repressed by the ventralizing factor BMP-4. When FGF signaling is blocked by a dominant-negative FGF receptor in chd-injected animal caps, neural induction is inhibited and most of the explant is induced to become endoderm. The results suggest that proteins secreted by the organizer, acting together with known peptide growth factors, regulate differentiation of the endodermal germ layer." @default.
- W1495424955 created "2016-06-24" @default.
- W1495424955 creator A5045672322 @default.
- W1495424955 creator A5051274527 @default.
- W1495424955 creator A5059692464 @default.
- W1495424955 creator A5061518807 @default.
- W1495424955 date "1996-09-01" @default.
- W1495424955 modified "2023-10-02" @default.
- W1495424955 title "Endoderm induction by the organizer-secreted factors chordin and noggin in Xenopus animal caps." @default.
- W1495424955 cites W1508614996 @default.
- W1495424955 cites W1532920122 @default.
- W1495424955 cites W1594765203 @default.
- W1495424955 cites W1890398355 @default.
- W1495424955 cites W1890787892 @default.
- W1495424955 cites W1927305112 @default.
- W1495424955 cites W1965980379 @default.
- W1495424955 cites W1970519235 @default.
- W1495424955 cites W1973812449 @default.
- W1495424955 cites W1974576894 @default.
- W1495424955 cites W1980096700 @default.
- W1495424955 cites W1990938412 @default.
- W1495424955 cites W1993154580 @default.
- W1495424955 cites W1998000268 @default.
- W1495424955 cites W1998342476 @default.
- W1495424955 cites W2004559089 @default.
- W1495424955 cites W2011175428 @default.
- W1495424955 cites W2014048648 @default.
- W1495424955 cites W2024946238 @default.
- W1495424955 cites W2026962630 @default.
- W1495424955 cites W2027432488 @default.
- W1495424955 cites W2033418096 @default.
- W1495424955 cites W2046597024 @default.
- W1495424955 cites W2047165320 @default.
- W1495424955 cites W2053093350 @default.
- W1495424955 cites W2070849620 @default.
- W1495424955 cites W2071135527 @default.
- W1495424955 cites W2074597244 @default.
- W1495424955 cites W2078916993 @default.
- W1495424955 cites W2092911887 @default.
- W1495424955 cites W2101998972 @default.
- W1495424955 cites W2110825450 @default.
- W1495424955 cites W2116026731 @default.
- W1495424955 cites W2125068279 @default.
- W1495424955 cites W2125423296 @default.
- W1495424955 cites W2130006359 @default.
- W1495424955 cites W2135314961 @default.
- W1495424955 cites W2140767601 @default.
- W1495424955 cites W2155492266 @default.
- W1495424955 cites W2156659930 @default.
- W1495424955 cites W2165080402 @default.
- W1495424955 cites W2167415654 @default.
- W1495424955 cites W2169307843 @default.
- W1495424955 cites W2172086325 @default.
- W1495424955 cites W2183822742 @default.
- W1495424955 cites W2208796000 @default.
- W1495424955 cites W2346925206 @default.
- W1495424955 cites W2347083990 @default.
- W1495424955 cites W2383657268 @default.
- W1495424955 cites W2424345117 @default.
- W1495424955 cites W2782867758 @default.
- W1495424955 doi "https://doi.org/10.1002/j.1460-2075.1996.tb00832.x" @default.
- W1495424955 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/452184" @default.
- W1495424955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8887546" @default.
- W1495424955 hasPublicationYear "1996" @default.
- W1495424955 type Work @default.
- W1495424955 sameAs 1495424955 @default.
- W1495424955 citedByCount "237" @default.
- W1495424955 countsByYear W14954249552012 @default.
- W1495424955 countsByYear W14954249552013 @default.
- W1495424955 countsByYear W14954249552014 @default.
- W1495424955 countsByYear W14954249552015 @default.
- W1495424955 countsByYear W14954249552017 @default.
- W1495424955 countsByYear W14954249552018 @default.
- W1495424955 countsByYear W14954249552020 @default.
- W1495424955 countsByYear W14954249552021 @default.
- W1495424955 countsByYear W14954249552022 @default.
- W1495424955 countsByYear W14954249552023 @default.
- W1495424955 crossrefType "journal-article" @default.
- W1495424955 hasAuthorship W1495424955A5045672322 @default.
- W1495424955 hasAuthorship W1495424955A5051274527 @default.
- W1495424955 hasAuthorship W1495424955A5059692464 @default.
- W1495424955 hasAuthorship W1495424955A5061518807 @default.
- W1495424955 hasBestOaLocation W14954249552 @default.
- W1495424955 hasConcept C104317684 @default.
- W1495424955 hasConcept C107459253 @default.
- W1495424955 hasConcept C129536746 @default.
- W1495424955 hasConcept C134018914 @default.
- W1495424955 hasConcept C135073763 @default.
- W1495424955 hasConcept C145103041 @default.
- W1495424955 hasConcept C148738053 @default.
- W1495424955 hasConcept C170493617 @default.
- W1495424955 hasConcept C18155467 @default.
- W1495424955 hasConcept C194058213 @default.
- W1495424955 hasConcept C196843134 @default.
- W1495424955 hasConcept C2777164004 @default.
- W1495424955 hasConcept C2778761762 @default.
- W1495424955 hasConcept C2778831791 @default.
- W1495424955 hasConcept C2779535977 @default.