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• W1495466419 endingPage "3236" @default.
• W1495466419 startingPage "3225" @default.
• W1495466419 abstract "We have investigated the activation of the p38 MAPK pathway in response to CD40 engagement in multiple B cell lines and in human tonsillar B cells to define the role of p38 MAPK in proliferation, NF-kappaB activation and gene expression. Cross-linking CD40 rapidly stimulates both p38 MAPK and its downstream effector, MAPKAPK-2. Inhibition of p38 MAPK activity in vivo with the specific cell-permeable inhibitor, SB203580, under conditions that completely prevented MAPKAPK-2 activation, strongly perturbed CD40-induced tonsillar B cell proliferation while potentiating the B cell receptor (BCR)-driven proliferative response. SB203580 also significantly reduced expression of a reporter gene driven by a minimal promoter containing four NF-kappaB elements, indicating a requirement for the p38 MAPK pathway in CD40-induced NF-kappaB activation. However, CD40-mediated NF-kappaB binding was not affected by SB203580, suggesting that NF-kappaB may not be a direct target for the CD40-induced p38 MAPK pathway. In addition, SB203580 selectively reduced CD40-induced CD54/ICAM-1 expression, whereas CD40-dependent expression of CD40 and CD95/Fas and four newly defined CD40-responsive genes cIAP2, TRAF1, TRAF4/CART and DR3 were unaffected. Our observations show that the p38 MAPK pathway is required for CD40-induced proliferation and that CD40 induces gene expression via both p38 MAPK-dependent and -independent pathways." @default.
• W1495466419 created "2016-06-24" @default.
• W1495466419 creator A5004809714 @default.
• W1495466419 creator A5007665730 @default.
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• W1495466419 creator A5032353741 @default.
• W1495466419 creator A5052111707 @default.
• W1495466419 creator A5061887843 @default.
• W1495466419 date "1998-10-01" @default.
• W1495466419 modified "2023-10-15" @default.
• W1495466419 title "p38 MAPK Is Required for CD40-Induced Gene Expression and Proliferation in B Lymphocytes" @default.
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• W1495466419 doi "https://doi.org/10.4049/jimmunol.161.7.3225" @default.
• W1495466419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9759836" @default.

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