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- W1495484726 abstract "Donor-recipient incompatibility (D + R -) for HLA-DQ1, but not for -DQ2 or -DQ3, is associated with an adverse effect on cadaver kidney graft survival. Until now, however, DQ1 recipients of DQ1-negative kidneys (D - R +) have not been differentiated from DQ1-identical donor-recipient pairs (D + R +) and splits of DQ1, DQ5 and DQ6, have not been studied in that respect. From our data (480 transplantations performed from January 1980 to December 1990), three donor-recipient DQ combinations (D + R +, D - R +, D + R -) were formed for each of four DQ specificities (DQ2, DQ3, DQ5, DQ6). As DR-DQ linkage disequilibrium is well conserved in caucasoid individuals, DQ specificities were inferred from the associated DR specificities. Graft survival rate (%) was significantly lower for the DQ5 D + R - and the DQ6 D - R + combinations when compared with the other corresponding DQ combinations, whereas no significant difference was observed between the DQ2 and DQ3 combinations. In conclusion, if DQ1 plays a prominent role in kidney graft survival, the effects of its splits appear dissociated: DQ5 could be a marker of high antigenicity and DQ6 a marker of high responsiveness." @default.
- W1495484726 created "2016-06-24" @default.
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- W1495484726 date "1992-01-01" @default.
- W1495484726 modified "2023-09-27" @default.
- W1495484726 title "Detrimental role of donor-recipient HLA-DQ5 and -DQ6 disparities on cadaver kidney graft survival" @default.
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- W1495484726 doi "https://doi.org/10.1007/978-3-642-77423-2_45" @default.
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- W1495484726 hasPublicationYear "1992" @default.
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