FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1495499025> ?p ?o ?g. }

• W1495499025 endingPage "6926" @default.
• W1495499025 startingPage "6918" @default.
• W1495499025 abstract "Abstract Chromogranin A (CgA) is an acidic glycoprotein, which is widely expressed in endocrine and neuroendocrine cells. It plays multiple important roles in the process of regulated hormone secretion. The single copy human CgA gene was isolated from a human fetal liver gene library. The gene spans 15 kilobases and contains 8 exons. Exon I encodes the 5'-noncoding region and the majority of the signal peptide coding region. Exons II-V collectively encode the highly conserved amino-terminal domain (the beta-granin sequence). Exon VI encodes a variable domain within which is the chromostatin sequence, and exon VII encodes another variable domain, which contains the pancreastatin sequence. Exon VIII encodes the highly conserved carboxyl-terminal domain and the 3'-noncoding region. The human gene promoter has a consensus TATA box, cAMP response element, and Sp-I sequence. 2.3 kilobases of the upstream regulatory region of the human CgA gene directed efficient transcription of a reporter chloramphenicol acetyltransferase gene in several neuroendocrine cell lines, including human medullary thyroid C-cell tumor, mouse pituitary corticotroph, rat pituitary tumor, and rat pheochromocytoma. The promoter was virtually inactive in nonneuroendocrine cell lines. Transient transfection studies with deleted promoter constructs showed that sequences lying between -55 and +32 base pairs relative to the transcription initiation site, containing the consensus cyclic AMP response element and TATA box, were sufficient for neuroendocrine cell-specific expression." @default.
• W1495499025 created "2016-06-24" @default.
• W1495499025 creator A5041687568 @default.
• W1495499025 creator A5047665894 @default.
• W1495499025 creator A5077463560 @default.
• W1495499025 creator A5086850461 @default.
• W1495499025 date "1994-03-01" @default.
• W1495499025 modified "2023-10-16" @default.
• W1495499025 title "Human chromogranin A gene. Molecular cloning, structural analysis, and neuroendocrine cell-specific expression." @default.
• W1495499025 cites W128815045 @default.
• W1495499025 cites W1485703332 @default.
• W1495499025 cites W1511672090 @default.
• W1495499025 cites W1527771705 @default.
• W1495499025 cites W1559446815 @default.
• W1495499025 cites W1569722645 @default.
• W1495499025 cites W1570515175 @default.
• W1495499025 cites W1610966535 @default.
• W1495499025 cites W1679079033 @default.
• W1495499025 cites W1965520579 @default.
• W1495499025 cites W1966404300 @default.
• W1495499025 cites W1976610863 @default.
• W1495499025 cites W1977707793 @default.
• W1495499025 cites W1982598173 @default.
• W1495499025 cites W1986718205 @default.
• W1495499025 cites W1996746282 @default.
• W1495499025 cites W1997176426 @default.
• W1495499025 cites W2026158891 @default.
• W1495499025 cites W2032764582 @default.
• W1495499025 cites W2043298840 @default.
• W1495499025 cites W2054684040 @default.
• W1495499025 cites W2058353405 @default.
• W1495499025 cites W2060333964 @default.
• W1495499025 cites W2063020372 @default.
• W1495499025 cites W2072214885 @default.
• W1495499025 cites W2073374044 @default.
• W1495499025 cites W2073869462 @default.
• W1495499025 cites W2074151872 @default.
• W1495499025 cites W2075070965 @default.
• W1495499025 cites W2079773832 @default.
• W1495499025 cites W2084219574 @default.
• W1495499025 cites W2084889874 @default.
• W1495499025 cites W2086708288 @default.
• W1495499025 cites W2088404041 @default.
• W1495499025 cites W2089039880 @default.
• W1495499025 cites W2092657822 @default.
• W1495499025 cites W2093609695 @default.
• W1495499025 cites W2095142337 @default.
• W1495499025 cites W2095234743 @default.
• W1495499025 cites W2095239868 @default.
• W1495499025 cites W2102679512 @default.
• W1495499025 cites W2135274630 @default.
• W1495499025 cites W2138270253 @default.
• W1495499025 cites W2143699001 @default.
• W1495499025 cites W2154787431 @default.
• W1495499025 cites W2164527218 @default.
• W1495499025 doi "https://doi.org/10.1016/s0021-9258(17)37462-8" @default.
• W1495499025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8120054" @default.
• W1495499025 hasPublicationYear "1994" @default.
• W1495499025 type Work @default.
• W1495499025 sameAs 1495499025 @default.
• W1495499025 citedByCount "71" @default.
• W1495499025 countsByYear W14954990252012 @default.
• W1495499025 countsByYear W14954990252015 @default.
• W1495499025 countsByYear W14954990252016 @default.
• W1495499025 countsByYear W14954990252017 @default.
• W1495499025 countsByYear W14954990252018 @default.
• W1495499025 countsByYear W14954990252021 @default.
• W1495499025 countsByYear W14954990252022 @default.
• W1495499025 crossrefType "journal-article" @default.
• W1495499025 hasAuthorship W1495499025A5041687568 @default.
• W1495499025 hasAuthorship W1495499025A5047665894 @default.
• W1495499025 hasAuthorship W1495499025A5077463560 @default.
• W1495499025 hasAuthorship W1495499025A5086850461 @default.
• W1495499025 hasBestOaLocation W14954990251 @default.
• W1495499025 hasConcept C104317684 @default.
• W1495499025 hasConcept C121050878 @default.
• W1495499025 hasConcept C150194340 @default.
• W1495499025 hasConcept C153911025 @default.
• W1495499025 hasConcept C19924922 @default.
• W1495499025 hasConcept C199360897 @default.
• W1495499025 hasConcept C203014093 @default.
• W1495499025 hasConcept C204232928 @default.
• W1495499025 hasConcept C41008148 @default.
• W1495499025 hasConcept C54355233 @default.
• W1495499025 hasConcept C70721500 @default.
• W1495499025 hasConcept C77231918 @default.
• W1495499025 hasConcept C86803240 @default.
• W1495499025 hasConceptScore W1495499025C104317684 @default.
• W1495499025 hasConceptScore W1495499025C121050878 @default.
• W1495499025 hasConceptScore W1495499025C150194340 @default.
• W1495499025 hasConceptScore W1495499025C153911025 @default.
• W1495499025 hasConceptScore W1495499025C19924922 @default.
• W1495499025 hasConceptScore W1495499025C199360897 @default.
• W1495499025 hasConceptScore W1495499025C203014093 @default.
• W1495499025 hasConceptScore W1495499025C204232928 @default.
• W1495499025 hasConceptScore W1495499025C41008148 @default.
• W1495499025 hasConceptScore W1495499025C54355233 @default.
• W1495499025 hasConceptScore W1495499025C70721500 @default.

• next