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- W1495501847 abstract "The AMP-activated serine/threonine protein kinase (AMPK) is a sensor of cellular energy status found in all eukaryotes—that is, activated under conditions of low-intracellular adenosine triphosphate (ATP) following cellular stress. One of the major downstream signaling pathways regulated by AMPK is the mammalian target-of-rapamycin (mTOR pathway). Like AMPK, the mTOR serine/threonine kinase plays key roles in growth control and cell proliferation and also in metabolism. Across eukaryotes mTOR orthologs are found in two biochemically distinct complexes and only one of those complexes (mTORC1 in mammals) is acutely sensitive to rapamycin and regulated by nutrients and AMPK. AMPK directly phosphorylates at least two proteins to induce rapid inhibition of mTORC1 activity, the tuberous sclerosis protein 2 (TSC2) tumor suppressor and the mTOR binding partner raptor. The chapter explores the molecular connections between AMPK and mTOR signaling pathways and examines the physiological processes in which AMPK regulation of mTOR is critical for growth or metabolic control. The AMP-activated protein kinase (AMPK) is a heterotrimeric kinase complex composed of a catalytic (α) subunit and two regulatory (β and γ) subunits." @default.
- W1495501847 created "2016-06-24" @default.
- W1495501847 creator A5010545585 @default.
- W1495501847 creator A5061151936 @default.
- W1495501847 date "2010-01-01" @default.
- W1495501847 modified "2023-10-09" @default.
- W1495501847 title "AMPK Control of mTOR Signaling and Growth" @default.
- W1495501847 cites W1589421810 @default.
- W1495501847 cites W1619256199 @default.
- W1495501847 cites W1906190805 @default.
- W1495501847 cites W1964327488 @default.
- W1495501847 cites W1965414585 @default.
- W1495501847 cites W1969542174 @default.
- W1495501847 cites W1970205234 @default.
- W1495501847 cites W1972256263 @default.
- W1495501847 cites W1972618720 @default.
- W1495501847 cites W1973856122 @default.
- W1495501847 cites W1976068103 @default.
- W1495501847 cites W1979380712 @default.
- W1495501847 cites W1980359753 @default.
- W1495501847 cites W1982450147 @default.
- W1495501847 cites W1988609792 @default.
- W1495501847 cites W1988848089 @default.
- W1495501847 cites W1989658063 @default.
- W1495501847 cites W1992170852 @default.
- W1495501847 cites W1992257057 @default.
- W1495501847 cites W1992304595 @default.
- W1495501847 cites W1994305081 @default.
- W1495501847 cites W1994823455 @default.
- W1495501847 cites W1998969528 @default.
- W1495501847 cites W2001568034 @default.
- W1495501847 cites W2002741326 @default.
- W1495501847 cites W2004380965 @default.
- W1495501847 cites W2006227722 @default.
- W1495501847 cites W2010161321 @default.
- W1495501847 cites W2010238890 @default.
- W1495501847 cites W2012142261 @default.
- W1495501847 cites W2014758663 @default.
- W1495501847 cites W2015164635 @default.
- W1495501847 cites W2016869069 @default.
- W1495501847 cites W2017886244 @default.
- W1495501847 cites W2018553282 @default.
- W1495501847 cites W2025391287 @default.
- W1495501847 cites W2026967508 @default.
- W1495501847 cites W2027107867 @default.
- W1495501847 cites W2029938976 @default.
- W1495501847 cites W2030031350 @default.
- W1495501847 cites W2030907978 @default.
- W1495501847 cites W2032601727 @default.
- W1495501847 cites W2033139959 @default.
- W1495501847 cites W2037177985 @default.
- W1495501847 cites W2041308494 @default.
- W1495501847 cites W2044656929 @default.
- W1495501847 cites W2045201133 @default.
- W1495501847 cites W2047392757 @default.
- W1495501847 cites W2047848415 @default.
- W1495501847 cites W2048267629 @default.
- W1495501847 cites W2050790870 @default.
- W1495501847 cites W2052093947 @default.
- W1495501847 cites W2053134659 @default.
- W1495501847 cites W2053848504 @default.
- W1495501847 cites W2056040807 @default.
- W1495501847 cites W2056673369 @default.
- W1495501847 cites W2057764483 @default.
- W1495501847 cites W2059825898 @default.
- W1495501847 cites W2061075485 @default.
- W1495501847 cites W2065850832 @default.
- W1495501847 cites W2066659565 @default.
- W1495501847 cites W2067152194 @default.
- W1495501847 cites W2068152515 @default.
- W1495501847 cites W2070224555 @default.
- W1495501847 cites W2070380343 @default.
- W1495501847 cites W2072611842 @default.
- W1495501847 cites W2072799497 @default.
- W1495501847 cites W2073656814 @default.
- W1495501847 cites W2073701988 @default.
- W1495501847 cites W2074894911 @default.
- W1495501847 cites W2075035517 @default.
- W1495501847 cites W2075496544 @default.
- W1495501847 cites W2076826746 @default.
- W1495501847 cites W2077203214 @default.
- W1495501847 cites W2077612844 @default.
- W1495501847 cites W2077645437 @default.
- W1495501847 cites W2078903854 @default.
- W1495501847 cites W2080100938 @default.
- W1495501847 cites W2081920342 @default.
- W1495501847 cites W2085888624 @default.
- W1495501847 cites W2086589626 @default.
- W1495501847 cites W2086691574 @default.
- W1495501847 cites W2087766892 @default.
- W1495501847 cites W2088469990 @default.
- W1495501847 cites W2089119460 @default.
- W1495501847 cites W2089718643 @default.
- W1495501847 cites W2094395583 @default.
- W1495501847 cites W2095081144 @default.
- W1495501847 cites W2095358591 @default.
- W1495501847 cites W2096591765 @default.
- W1495501847 cites W2100215155 @default.