FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1495637560> ?p ?o ?g. }

• W1495637560 endingPage "16" @default.
• W1495637560 startingPage "1" @default.
• W1495637560 abstract "Abstract In this chapter, the metabolism of psychotropic drugs is explained. The most important enzymes are the polymorphic cytochrome P450 enzymes CYP2D6, CYP2C19, and CYP2C9. The functional impact of other drug‐metabolizing enzymes including CYP1A2, CYP2A6, CYP2B6, CYP3A4, CYP3A5, and CYP3A7 or phase II enzymes in psychopharmacology is less, but some agents are cleared predominantly by the latter pathways. The clinical importance of drug metabolism is mainly determined by alteration of the individual activity of a relevant drug‐metabolizing enzyme. This is frequently the case in drug–drug interactions leading to enzyme inhibition or enzyme induction. Alternatively, individual patient factors such as pharmacogenetic polymorphisms may contribute to variability in CYP isozyme activity. In this chapter, specific metabolism of antidepressant and antipsychotic drugs is presented for the main CYP enzymes CYP2D6, CYP2C19, CYP2C9, and CYP1A2 and the impact of genetic polymorphisms in these enzymes is pointed out. As many psychotropic drugs are metabolized to equally active metabolites, more than one CYP isoform may be important in metabolism and exposure data of both metabolite and parent drug have to be taken into account. For many antidepressants or antipsychotic drugs, therapeutic drug monitoring is practiced regularly." @default.
• W1495637560 created "2016-06-24" @default.
• W1495637560 creator A5044013990 @default.
• W1495637560 creator A5064941332 @default.
• W1495637560 creator A5080262638 @default.
• W1495637560 date "2012-01-31" @default.
• W1495637560 modified "2023-10-12" @default.
• W1495637560 title "Metabolism of Psychotropic Drugs" @default.
• W1495637560 cites W1488321941 @default.
• W1495637560 cites W1544511641 @default.
• W1495637560 cites W179281078 @default.
• W1495637560 cites W1963984456 @default.
• W1495637560 cites W1964688493 @default.
• W1495637560 cites W1966248443 @default.
• W1495637560 cites W1968322454 @default.
• W1495637560 cites W1976578019 @default.
• W1495637560 cites W1979177892 @default.
• W1495637560 cites W1979980024 @default.
• W1495637560 cites W1982290436 @default.
• W1495637560 cites W1985324190 @default.
• W1495637560 cites W1991536886 @default.
• W1495637560 cites W1991625714 @default.
• W1495637560 cites W1992738149 @default.
• W1495637560 cites W1996605119 @default.
• W1495637560 cites W2000595776 @default.
• W1495637560 cites W2001003832 @default.
• W1495637560 cites W2001657113 @default.
• W1495637560 cites W2002050650 @default.
• W1495637560 cites W2004557299 @default.
• W1495637560 cites W2004978631 @default.
• W1495637560 cites W2005244872 @default.
• W1495637560 cites W2008318035 @default.
• W1495637560 cites W2016029871 @default.
• W1495637560 cites W2016228987 @default.
• W1495637560 cites W2017341632 @default.
• W1495637560 cites W2019823288 @default.
• W1495637560 cites W2023120509 @default.
• W1495637560 cites W2026995360 @default.
• W1495637560 cites W2027167584 @default.
• W1495637560 cites W2029102065 @default.
• W1495637560 cites W2029995473 @default.
• W1495637560 cites W2031625516 @default.
• W1495637560 cites W2032164227 @default.
• W1495637560 cites W2035867772 @default.
• W1495637560 cites W2038059828 @default.
• W1495637560 cites W2040194216 @default.
• W1495637560 cites W2041253701 @default.
• W1495637560 cites W2045654730 @default.
• W1495637560 cites W2049881228 @default.
• W1495637560 cites W205746511 @default.
• W1495637560 cites W2057845591 @default.
• W1495637560 cites W2062106705 @default.
• W1495637560 cites W2067522770 @default.
• W1495637560 cites W2068398215 @default.
• W1495637560 cites W2068485725 @default.
• W1495637560 cites W2068780263 @default.
• W1495637560 cites W2072085343 @default.
• W1495637560 cites W2073161666 @default.
• W1495637560 cites W2075881925 @default.
• W1495637560 cites W2080382785 @default.
• W1495637560 cites W2082312328 @default.
• W1495637560 cites W2083224028 @default.
• W1495637560 cites W2084497711 @default.
• W1495637560 cites W2088359472 @default.
• W1495637560 cites W2092173951 @default.
• W1495637560 cites W2094440982 @default.
• W1495637560 cites W2094500585 @default.
• W1495637560 cites W2109016467 @default.
• W1495637560 cites W2113275980 @default.
• W1495637560 cites W2117628306 @default.
• W1495637560 cites W2124319527 @default.
• W1495637560 cites W2148875560 @default.
• W1495637560 cites W2154937949 @default.
• W1495637560 cites W2157289463 @default.
• W1495637560 cites W2163713210 @default.
• W1495637560 cites W2167407582 @default.
• W1495637560 cites W2168445796 @default.
• W1495637560 cites W2193494830 @default.
• W1495637560 cites W2319976610 @default.
• W1495637560 cites W2320195367 @default.
• W1495637560 cites W2328822410 @default.
• W1495637560 cites W4295677733 @default.
• W1495637560 cites W4298130947 @default.
• W1495637560 doi "https://doi.org/10.1002/9780470921920.edm130" @default.
• W1495637560 hasPublicationYear "2012" @default.
• W1495637560 type Work @default.
• W1495637560 sameAs 1495637560 @default.
• W1495637560 citedByCount "1" @default.
• W1495637560 countsByYear W14956375602021 @default.
• W1495637560 crossrefType "other" @default.
• W1495637560 hasAuthorship W1495637560A5044013990 @default.
• W1495637560 hasAuthorship W1495637560A5064941332 @default.
• W1495637560 hasAuthorship W1495637560A5080262638 @default.
• W1495637560 hasConcept C104317684 @default.
• W1495637560 hasConcept C109650736 @default.
• W1495637560 hasConcept C118552586 @default.
• W1495637560 hasConcept C119795356 @default.
• W1495637560 hasConcept C135763542 @default.

• next