FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1495697228> ?p ?o ?g. }

• W1495697228 endingPage "18504" @default.
• W1495697228 startingPage "18495" @default.
• W1495697228 abstract "Segment 5, ORF 1 of the infectious salmon anemia virus (ISAV) genome, encodes for the ISAV F protein, which is responsible for viral-host endosomal membrane fusion during a productive ISAV infection. The entry machinery of ISAV is composed of a complex of the ISAV F and ISAV hemagglutinin esterase (HE) proteins in an unknown stoichiometry prior to receptor engagement by ISAV HE. Following binding of the receptor to ISAV HE, dissociation of the ISAV F protein from HE, and subsequent endocytosis, the ISAV F protein resolves into a fusion-competent oligomeric state. Here, we present a 2.1 A crystal structure of the fusion core of the ISAV F protein determined at low pH. This structure has allowed us to unambiguously demonstrate that the ISAV entry machinery exhibits typical class I viral fusion protein architecture. Furthermore, we have determined stabilizing factors that accommodate the pH-dependent mode of ISAV transmission, and our structure has allowed the identification of a central coil that is conserved across numerous and varied post-fusion viral glycoprotein structures. We then discuss a mechanistic model of ISAV fusion that parallels the paramyxoviral class I fusion strategy wherein attachment and fusion are relegated to separate proteins in a similar fashion to ISAV fusion." @default.
• W1495697228 created "2016-06-24" @default.
• W1495697228 creator A5022491856 @default.
• W1495697228 creator A5029274408 @default.
• W1495697228 creator A5036581307 @default.
• W1495697228 creator A5066016553 @default.
• W1495697228 date "2015-07-01" @default.
• W1495697228 modified "2023-09-29" @default.
• W1495697228 title "Electrostatic Architecture of the Infectious Salmon Anemia Virus (ISAV) Core Fusion Protein Illustrates a Carboxyl-Carboxylate pH Sensor" @default.
• W1495697228 cites W1566394066 @default.
• W1495697228 cites W1965136586 @default.
• W1495697228 cites W1965167723 @default.
• W1495697228 cites W1978763290 @default.
• W1495697228 cites W1978816549 @default.
• W1495697228 cites W1988313572 @default.
• W1495697228 cites W1992649987 @default.
• W1495697228 cites W1997511430 @default.
• W1495697228 cites W1999721596 @default.
• W1495697228 cites W2010622646 @default.
• W1495697228 cites W2013144572 @default.
• W1495697228 cites W2024166788 @default.
• W1495697228 cites W2024645073 @default.
• W1495697228 cites W2026504028 @default.
• W1495697228 cites W2030517878 @default.
• W1495697228 cites W2032155561 @default.
• W1495697228 cites W2044447130 @default.
• W1495697228 cites W2045868762 @default.
• W1495697228 cites W2046563809 @default.
• W1495697228 cites W2055050774 @default.
• W1495697228 cites W2057730654 @default.
• W1495697228 cites W2061058307 @default.
• W1495697228 cites W2077602926 @default.
• W1495697228 cites W2088750194 @default.
• W1495697228 cites W2089923517 @default.
• W1495697228 cites W2103489606 @default.
• W1495697228 cites W2120658521 @default.
• W1495697228 cites W2122994276 @default.
• W1495697228 cites W2127130852 @default.
• W1495697228 cites W2127322768 @default.
• W1495697228 cites W2130031722 @default.
• W1495697228 cites W2137724478 @default.
• W1495697228 cites W2143312809 @default.
• W1495697228 cites W2144081223 @default.
• W1495697228 cites W2145095568 @default.
• W1495697228 cites W2147025823 @default.
• W1495697228 cites W2147098571 @default.
• W1495697228 cites W2147267550 @default.
• W1495697228 cites W2154197653 @default.
• W1495697228 cites W2156171429 @default.
• W1495697228 cites W2163341755 @default.
• W1495697228 cites W2169544411 @default.
• W1495697228 cites W2313447121 @default.
• W1495697228 cites W4210675630 @default.
• W1495697228 cites W4248872320 @default.
• W1495697228 doi "https://doi.org/10.1074/jbc.m115.644781" @default.
• W1495697228 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4513110" @default.
• W1495697228 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26082488" @default.
• W1495697228 hasPublicationYear "2015" @default.
• W1495697228 type Work @default.
• W1495697228 sameAs 1495697228 @default.
• W1495697228 citedByCount "11" @default.
• W1495697228 countsByYear W14956972282015 @default.
• W1495697228 countsByYear W14956972282017 @default.
• W1495697228 countsByYear W14956972282019 @default.
• W1495697228 countsByYear W14956972282020 @default.
• W1495697228 countsByYear W14956972282021 @default.
• W1495697228 countsByYear W14956972282022 @default.
• W1495697228 crossrefType "journal-article" @default.
• W1495697228 hasAuthorship W1495697228A5022491856 @default.
• W1495697228 hasAuthorship W1495697228A5029274408 @default.
• W1495697228 hasAuthorship W1495697228A5036581307 @default.
• W1495697228 hasAuthorship W1495697228A5066016553 @default.
• W1495697228 hasBestOaLocation W14956972281 @default.
• W1495697228 hasConcept C159047783 @default.
• W1495697228 hasConcept C185592680 @default.
• W1495697228 hasConcept C2522874641 @default.
• W1495697228 hasConcept C2778074193 @default.
• W1495697228 hasConcept C2781053568 @default.
• W1495697228 hasConcept C2992769111 @default.
• W1495697228 hasConcept C55493867 @default.
• W1495697228 hasConcept C86803240 @default.
• W1495697228 hasConceptScore W1495697228C159047783 @default.
• W1495697228 hasConceptScore W1495697228C185592680 @default.
• W1495697228 hasConceptScore W1495697228C2522874641 @default.
• W1495697228 hasConceptScore W1495697228C2778074193 @default.
• W1495697228 hasConceptScore W1495697228C2781053568 @default.
• W1495697228 hasConceptScore W1495697228C2992769111 @default.
• W1495697228 hasConceptScore W1495697228C55493867 @default.
• W1495697228 hasConceptScore W1495697228C86803240 @default.
• W1495697228 hasIssue "30" @default.
• W1495697228 hasLocation W14956972281 @default.
• W1495697228 hasLocation W14956972282 @default.
• W1495697228 hasLocation W14956972283 @default.
• W1495697228 hasOpenAccess W1495697228 @default.
• W1495697228 hasPrimaryLocation W14956972281 @default.
• W1495697228 hasRelatedWork W1923224286 @default.
• W1495697228 hasRelatedWork W1963591309 @default.
• W1495697228 hasRelatedWork W1974843652 @default.

• next