Matches in SemOpenAlex for { <https://semopenalex.org/work/W1495764983> ?p ?o ?g. }
- W1495764983 endingPage "1747" @default.
- W1495764983 startingPage "1737" @default.
- W1495764983 abstract "BACKGROUND AND PURPOSE Inhaled corticosteroids (ICS) are the cornerstone of asthma pharmacotherapy and, acting via the glucocorticoid receptor (GR), reduce inflammatory gene expression. While this is often attributed to a direct inhibitory effect of the GR on inflammatory gene transcription, corticosteroids also induce the expression of anti‐inflammatory genes in vitro . As there are no data to support this effect in asthmatic subjects taking ICS, we have assessed whether ICS induce anti‐inflammatory gene expression in subjects with atopic asthma. EXPERIMENTAL APPROACH Bronchial biopsies from allergen‐challenged atopic asthmatic subjects taking inhaled budesonide or placebo were subjected to gene expression analysis using real‐time reverse transcriptase‐PCR for the corticosteroid‐inducible genes (official gene symbols with aliases in parentheses): TSC22D3 [glucocorticoid‐induced leucine zipper (GILZ)], dual‐specificity phosphatase‐1 (MAPK phosphatase‐1), both anti‐inflammatory effectors, and FKBP5 [FK506‐binding protein 51 (FKBP51)], a regulator of GR function. Cultured pulmonary epithelial and smooth muscle cells were also treated with corticosteroids before gene expression analysis. KEY RESULTS Compared with placebo, GILZ and FKBP51 mRNA expression was significantly elevated in budesonide‐treated subjects. Budesonide also increased GILZ expression in human epithelial and smooth muscle cells in culture. Immunostaining of bronchial biopsies revealed GILZ expression in the airways epithelium and smooth muscle of asthmatic subjects. CONCLUSIONS AND IMPLICATIONS Expression of the corticosteroid‐induced genes, GILZ and FKBP51, is up‐regulated in the airways of allergen‐challenged asthmatic subjects taking inhaled budesonide. Consequently, the biological effects of corticosteroid‐induced genes should be considered when assessing the actions of ICS. Treatment modalities that increase or decrease GR‐dependent transcription may correspondingly affect corticosteroid efficacy." @default.
- W1495764983 created "2016-06-24" @default.
- W1495764983 creator A5009909921 @default.
- W1495764983 creator A5022513797 @default.
- W1495764983 creator A5026147783 @default.
- W1495764983 creator A5029497606 @default.
- W1495764983 creator A5049410387 @default.
- W1495764983 creator A5052039927 @default.
- W1495764983 creator A5057664558 @default.
- W1495764983 creator A5068506060 @default.
- W1495764983 creator A5072809260 @default.
- W1495764983 creator A5081195905 @default.
- W1495764983 date "2012-02-22" @default.
- W1495764983 modified "2023-10-04" @default.
- W1495764983 title "Corticosteroid-induced gene expression in allergen-challenged asthmatic subjects taking inhaled budesonide" @default.
- W1495764983 cites W1717444875 @default.
- W1495764983 cites W1877755747 @default.
- W1495764983 cites W1899889608 @default.
- W1495764983 cites W1935602610 @default.
- W1495764983 cites W1964883544 @default.
- W1495764983 cites W1972068895 @default.
- W1495764983 cites W1974822812 @default.
- W1495764983 cites W1976253462 @default.
- W1495764983 cites W1983518744 @default.
- W1495764983 cites W1990157223 @default.
- W1495764983 cites W1991968623 @default.
- W1495764983 cites W1992040251 @default.
- W1495764983 cites W1997103341 @default.
- W1495764983 cites W2005698033 @default.
- W1495764983 cites W2006473625 @default.
- W1495764983 cites W2008244058 @default.
- W1495764983 cites W2009638401 @default.
- W1495764983 cites W2010566912 @default.
- W1495764983 cites W2030536223 @default.
- W1495764983 cites W2035090144 @default.
- W1495764983 cites W2043394718 @default.
- W1495764983 cites W2048316119 @default.
- W1495764983 cites W2053427642 @default.
- W1495764983 cites W2053568297 @default.
- W1495764983 cites W2063780624 @default.
- W1495764983 cites W2064095640 @default.
- W1495764983 cites W2065295359 @default.
- W1495764983 cites W2066202970 @default.
- W1495764983 cites W2069372817 @default.
- W1495764983 cites W2076544702 @default.
- W1495764983 cites W2087669700 @default.
- W1495764983 cites W2095831813 @default.
- W1495764983 cites W2096142796 @default.
- W1495764983 cites W2097483036 @default.
- W1495764983 cites W2097878238 @default.
- W1495764983 cites W2102332699 @default.
- W1495764983 cites W2106372965 @default.
- W1495764983 cites W2106471110 @default.
- W1495764983 cites W2107777844 @default.
- W1495764983 cites W2109301274 @default.
- W1495764983 cites W2109918049 @default.
- W1495764983 cites W2110431512 @default.
- W1495764983 cites W2110657360 @default.
- W1495764983 cites W2115289014 @default.
- W1495764983 cites W2117363076 @default.
- W1495764983 cites W2128177613 @default.
- W1495764983 cites W2134510352 @default.
- W1495764983 cites W2136199835 @default.
- W1495764983 cites W2145906341 @default.
- W1495764983 cites W2147397196 @default.
- W1495764983 cites W2148622539 @default.
- W1495764983 cites W2149115445 @default.
- W1495764983 cites W2153195809 @default.
- W1495764983 cites W2159379486 @default.
- W1495764983 doi "https://doi.org/10.1111/j.1476-5381.2011.01620.x" @default.
- W1495764983 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3372826" @default.
- W1495764983 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21827450" @default.
- W1495764983 hasPublicationYear "2012" @default.
- W1495764983 type Work @default.
- W1495764983 sameAs 1495764983 @default.
- W1495764983 citedByCount "76" @default.
- W1495764983 countsByYear W14957649832012 @default.
- W1495764983 countsByYear W14957649832013 @default.
- W1495764983 countsByYear W14957649832014 @default.
- W1495764983 countsByYear W14957649832015 @default.
- W1495764983 countsByYear W14957649832016 @default.
- W1495764983 countsByYear W14957649832017 @default.
- W1495764983 countsByYear W14957649832018 @default.
- W1495764983 countsByYear W14957649832019 @default.
- W1495764983 countsByYear W14957649832020 @default.
- W1495764983 countsByYear W14957649832021 @default.
- W1495764983 countsByYear W14957649832022 @default.
- W1495764983 crossrefType "journal-article" @default.
- W1495764983 hasAuthorship W1495764983A5009909921 @default.
- W1495764983 hasAuthorship W1495764983A5022513797 @default.
- W1495764983 hasAuthorship W1495764983A5026147783 @default.
- W1495764983 hasAuthorship W1495764983A5029497606 @default.
- W1495764983 hasAuthorship W1495764983A5049410387 @default.
- W1495764983 hasAuthorship W1495764983A5052039927 @default.
- W1495764983 hasAuthorship W1495764983A5057664558 @default.
- W1495764983 hasAuthorship W1495764983A5068506060 @default.
- W1495764983 hasAuthorship W1495764983A5072809260 @default.
- W1495764983 hasAuthorship W1495764983A5081195905 @default.