Matches in SemOpenAlex for { <https://semopenalex.org/work/W1495806076> ?p ?o ?g. }
- W1495806076 abstract "Drugs represent the primary treatment available for human malaria, as caused by Plasmodium spp. Currently approved drugs and antimalarial drug leads generally work against parasite enzymes or activities within infected erythrocytes. To reach their specific targets, these chemicals must cross at least three membranes beginning with the host cell membrane. Uptake at each membrane may involve partitioning and diffusion through the lipid bilayer or facilitated transport through channels or carriers. Here, we review the features of available antimalarials and examine whether transporters may be required for their uptake. Our computational analysis suggests that most antimalarials have high intrinsic membrane permeability, obviating the need for uptake via transporters; a subset of compounds appear to require facilitated uptake. We also review parasite and host transporters that may contribute to drug uptake. Broad permeability channels at the erythrocyte and parasitophorous vacuolar membranes of infected cells relax permeability constraints on antimalarial drug design; however, this uptake mechanism is prone to acquired resistance as the parasite may alter channel activity to reduce drug uptake. A better understanding of how antimalarial drugs reach their intracellular targets is critical to prioritizing drug leads for antimalarial development and may reveal new targets for therapeutic intervention." @default.
- W1495806076 created "2016-06-24" @default.
- W1495806076 creator A5023545632 @default.
- W1495806076 creator A5046001598 @default.
- W1495806076 creator A5065807103 @default.
- W1495806076 creator A5079791439 @default.
- W1495806076 creator A5086764406 @default.
- W1495806076 date "2015-05-05" @default.
- W1495806076 modified "2023-10-18" @default.
- W1495806076 title "How do antimalarial drugs reach their intracellular targets?" @default.
- W1495806076 cites W1518881552 @default.
- W1495806076 cites W1544507288 @default.
- W1495806076 cites W1586796410 @default.
- W1495806076 cites W191227402 @default.
- W1495806076 cites W1961061296 @default.
- W1495806076 cites W1967100058 @default.
- W1495806076 cites W1971909283 @default.
- W1495806076 cites W1973828942 @default.
- W1495806076 cites W1977414554 @default.
- W1495806076 cites W1982629676 @default.
- W1495806076 cites W1991443437 @default.
- W1495806076 cites W1999192138 @default.
- W1495806076 cites W2001686831 @default.
- W1495806076 cites W2004803790 @default.
- W1495806076 cites W2011505858 @default.
- W1495806076 cites W2015141554 @default.
- W1495806076 cites W2027230011 @default.
- W1495806076 cites W2028217000 @default.
- W1495806076 cites W2031576029 @default.
- W1495806076 cites W2039639971 @default.
- W1495806076 cites W2044790709 @default.
- W1495806076 cites W2045576713 @default.
- W1495806076 cites W2051940183 @default.
- W1495806076 cites W2055406877 @default.
- W1495806076 cites W2055792051 @default.
- W1495806076 cites W2057089852 @default.
- W1495806076 cites W2060407236 @default.
- W1495806076 cites W2061650979 @default.
- W1495806076 cites W2069797790 @default.
- W1495806076 cites W2071595022 @default.
- W1495806076 cites W2072900154 @default.
- W1495806076 cites W2076362614 @default.
- W1495806076 cites W2076959717 @default.
- W1495806076 cites W2082680042 @default.
- W1495806076 cites W2082804431 @default.
- W1495806076 cites W2083522771 @default.
- W1495806076 cites W2088624570 @default.
- W1495806076 cites W2103944234 @default.
- W1495806076 cites W2116510803 @default.
- W1495806076 cites W2118242241 @default.
- W1495806076 cites W2122524469 @default.
- W1495806076 cites W2123299920 @default.
- W1495806076 cites W2131021979 @default.
- W1495806076 cites W2133688074 @default.
- W1495806076 cites W2135732933 @default.
- W1495806076 cites W2139935246 @default.
- W1495806076 cites W2140647344 @default.
- W1495806076 cites W2143286910 @default.
- W1495806076 cites W2143977871 @default.
- W1495806076 cites W2144418945 @default.
- W1495806076 cites W2148820240 @default.
- W1495806076 cites W2150693438 @default.
- W1495806076 cites W2151454143 @default.
- W1495806076 cites W2152698588 @default.
- W1495806076 cites W2154313767 @default.
- W1495806076 cites W2154706050 @default.
- W1495806076 cites W2157619122 @default.
- W1495806076 cites W2158780951 @default.
- W1495806076 cites W2164960334 @default.
- W1495806076 cites W2165711991 @default.
- W1495806076 cites W2166050191 @default.
- W1495806076 cites W2177825381 @default.
- W1495806076 cites W2340565196 @default.
- W1495806076 cites W2341476264 @default.
- W1495806076 cites W2398116906 @default.
- W1495806076 cites W2419671499 @default.
- W1495806076 cites W2474816958 @default.
- W1495806076 doi "https://doi.org/10.3389/fphar.2015.00091" @default.
- W1495806076 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4419668" @default.
- W1495806076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25999857" @default.
- W1495806076 hasPublicationYear "2015" @default.
- W1495806076 type Work @default.
- W1495806076 sameAs 1495806076 @default.
- W1495806076 citedByCount "31" @default.
- W1495806076 countsByYear W14958060762015 @default.
- W1495806076 countsByYear W14958060762017 @default.
- W1495806076 countsByYear W14958060762018 @default.
- W1495806076 countsByYear W14958060762019 @default.
- W1495806076 countsByYear W14958060762020 @default.
- W1495806076 countsByYear W14958060762021 @default.
- W1495806076 countsByYear W14958060762022 @default.
- W1495806076 countsByYear W14958060762023 @default.
- W1495806076 crossrefType "journal-article" @default.
- W1495806076 hasAuthorship W1495806076A5023545632 @default.
- W1495806076 hasAuthorship W1495806076A5046001598 @default.
- W1495806076 hasAuthorship W1495806076A5065807103 @default.
- W1495806076 hasAuthorship W1495806076A5079791439 @default.
- W1495806076 hasAuthorship W1495806076A5086764406 @default.
- W1495806076 hasBestOaLocation W14958060761 @default.
- W1495806076 hasConcept C104317684 @default.