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- W1496069463 abstract "The reactions of horse globin reconstituted with proto-, deutero-, and mesoheme have been examined by equilibrium and kinetic methods. In virtually all reactions studied, mesohemoglobin displays the more extreme functional behavior, whereas deuterohemoglobin exhibits behavior which is either very similar to native hemoglobin or intermediate between the two. Our kinetic and equilibrium results indicate that the primary effect of heme modification on the functional properties of hemoglobin is to alter the intrinsic reactivities of the deoxy and liganded conformations. Heme modification does not, however, result in substantial alterations in the conformational equilibrium between the two states. Simple inductive electronic effects of the 2- and 4-substituents of the heme moiety in deutero- and mesohemoglobin are apparently not sufficient to explain the observed equilibrium and kinetic properties completely, which indicates that steric effects of these substituents may also play a role in determining the functional behavior of the hemoglobin molecule." @default.
- W1496069463 created "2016-06-24" @default.
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- W1496069463 date "1976-01-01" @default.
- W1496069463 modified "2023-09-30" @default.
- W1496069463 title "Ligand binding properties of horse hemoglobins containing deutero- and mesoheme." @default.
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- W1496069463 doi "https://doi.org/10.1016/s0021-9258(17)33924-8" @default.
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