Matches in SemOpenAlex for { <https://semopenalex.org/work/W1496114544> ?p ?o ?g. }
- W1496114544 endingPage "98" @default.
- W1496114544 startingPage "81" @default.
- W1496114544 abstract "Intracellular calcium activates contraction and a chloride conductance ICl(Ca) in mammalian heart. In normal ventricular or atrial cells ICl(Ca) and ITO1 provide re[olarizing current during action potential phases 1 and 2. The balance of currents early in the action potential, including late INa, ITO1, and ICl(Ca), are critical to initiation of arrhythmias associated with Brugada syndrome. Evidence from studies in the canine arterially perfused right ventricular wedge indicates that the prominent action potential notch found in epicardial cells permits plateau depression and dramatic shortening of action potentials in regions of the epicardium. This all-or-none repolarization initiates large differences in repolarization across the ventricular wall, setting the stage for various arrhythmias (Antzelevitch et al., 1999; Tada et al., 2000; Yan and Antzelevitch, 1999). The amplitude and duration of ICl(Ca) normally mirrors rate- and rhythm-dependent changes in the calcium transient. Injuries that alter normal excitation-contraction conpling will likely modify the amplitude of ICl(Ca) and the balance of currents during early repolarization. Ischemia reduces both peak calcium transients and ICl(Ca) in cells isolated from 5-day infarcted canine ventricle, and this reduction is most dramatic at fast pacing rates (Aggarwal et al., 1997). The amplitude of calcium transients is also reduced in a dog model of chronic rapid atrial pacing, and it would be interesting to discover how changes in ICl(Ca) might alter action potential duration in this rapid pacing model (Sun et al., 1998). In dog and sheep ventricles, ICl(Ca) and INaCa produce an oscillating inward current at diastolic voltages in calcium overloaded cells. These contraction-related currents initiate DADs and ectopic beats. Evidence from animal and human studies indicates reentry is the primary mechanism underlying arrhythmogenesis, but that focal mechanisms might initiate ventricular arrhythmias under certain pathophysiological conditions. Three-dimensional cardiac mapping performed in dogs with ischemic cardiomyopathy induced by intracoronary embolizations reveals that monomorphic ventricular tachycardia is due to focal activation of subendocardial sites (Pogwizd, 1994). Similarly, d-sotalol-induced polymorphic tachyarrhythmias with characteristics of torsade de pointes are initiated by spontaneous premature beats originating in the subendocardium (Shimizu and Antzelevitch, 1997). Such focal activation might arise as DADs originating in ventricular cells or Purkinje fibers. An important next step to understand the role of ICl(Ca) during reperfusion- and drug-induced arrhythmias will be to determine whether INaCa and ICl(Ca) are affected differently by intracellular pH, calcium loading of the SR, and the metabolic components of ischemia." @default.
- W1496114544 created "2016-06-24" @default.
- W1496114544 creator A5020349285 @default.
- W1496114544 date "2002-01-01" @default.
- W1496114544 modified "2023-09-27" @default.
- W1496114544 title "Physiological role of the Ca2+-activated Cl− current in mammalian heart" @default.
- W1496114544 cites W1776100550 @default.
- W1496114544 cites W1888174905 @default.
- W1496114544 cites W1968876226 @default.
- W1496114544 cites W1974153471 @default.
- W1496114544 cites W1975908160 @default.
- W1496114544 cites W1978819017 @default.
- W1496114544 cites W1979151581 @default.
- W1496114544 cites W1987074861 @default.
- W1496114544 cites W1990588060 @default.
- W1496114544 cites W2001326386 @default.
- W1496114544 cites W2004454757 @default.
- W1496114544 cites W2004582891 @default.
- W1496114544 cites W2016874657 @default.
- W1496114544 cites W2017018271 @default.
- W1496114544 cites W2023141575 @default.
- W1496114544 cites W2023909122 @default.
- W1496114544 cites W2030668240 @default.
- W1496114544 cites W2030815572 @default.
- W1496114544 cites W2041542093 @default.
- W1496114544 cites W2042110435 @default.
- W1496114544 cites W2043511431 @default.
- W1496114544 cites W2054808456 @default.
- W1496114544 cites W2057079115 @default.
- W1496114544 cites W2058178946 @default.
- W1496114544 cites W2058626030 @default.
- W1496114544 cites W2058967452 @default.
- W1496114544 cites W2059978332 @default.
- W1496114544 cites W2064879470 @default.
- W1496114544 cites W2071293796 @default.
- W1496114544 cites W2090853041 @default.
- W1496114544 cites W2099151502 @default.
- W1496114544 cites W2100955490 @default.
- W1496114544 cites W2101276997 @default.
- W1496114544 cites W2103367007 @default.
- W1496114544 cites W2123184686 @default.
- W1496114544 cites W2137067311 @default.
- W1496114544 cites W2163822375 @default.
- W1496114544 cites W2167744805 @default.
- W1496114544 cites W2187726356 @default.
- W1496114544 cites W2208482215 @default.
- W1496114544 cites W2241090036 @default.
- W1496114544 cites W2299017114 @default.
- W1496114544 cites W2398806623 @default.
- W1496114544 cites W2408030367 @default.
- W1496114544 cites W2409473863 @default.
- W1496114544 doi "https://doi.org/10.1016/s1063-5823(02)53029-5" @default.
- W1496114544 hasPublicationYear "2002" @default.
- W1496114544 type Work @default.
- W1496114544 sameAs 1496114544 @default.
- W1496114544 citedByCount "0" @default.
- W1496114544 crossrefType "book-chapter" @default.
- W1496114544 hasAuthorship W1496114544A5020349285 @default.
- W1496114544 hasConcept C101404756 @default.
- W1496114544 hasConcept C126322002 @default.
- W1496114544 hasConcept C134018914 @default.
- W1496114544 hasConcept C146403970 @default.
- W1496114544 hasConcept C147944092 @default.
- W1496114544 hasConcept C163415756 @default.
- W1496114544 hasConcept C164705383 @default.
- W1496114544 hasConcept C185263204 @default.
- W1496114544 hasConcept C185592680 @default.
- W1496114544 hasConcept C2778921608 @default.
- W1496114544 hasConcept C47423411 @default.
- W1496114544 hasConcept C519063684 @default.
- W1496114544 hasConcept C71924100 @default.
- W1496114544 hasConcept C87520248 @default.
- W1496114544 hasConceptScore W1496114544C101404756 @default.
- W1496114544 hasConceptScore W1496114544C126322002 @default.
- W1496114544 hasConceptScore W1496114544C134018914 @default.
- W1496114544 hasConceptScore W1496114544C146403970 @default.
- W1496114544 hasConceptScore W1496114544C147944092 @default.
- W1496114544 hasConceptScore W1496114544C163415756 @default.
- W1496114544 hasConceptScore W1496114544C164705383 @default.
- W1496114544 hasConceptScore W1496114544C185263204 @default.
- W1496114544 hasConceptScore W1496114544C185592680 @default.
- W1496114544 hasConceptScore W1496114544C2778921608 @default.
- W1496114544 hasConceptScore W1496114544C47423411 @default.
- W1496114544 hasConceptScore W1496114544C519063684 @default.
- W1496114544 hasConceptScore W1496114544C71924100 @default.
- W1496114544 hasConceptScore W1496114544C87520248 @default.
- W1496114544 hasLocation W14961145441 @default.
- W1496114544 hasOpenAccess W1496114544 @default.
- W1496114544 hasPrimaryLocation W14961145441 @default.
- W1496114544 hasRelatedWork W1578115391 @default.
- W1496114544 hasRelatedWork W1826128202 @default.
- W1496114544 hasRelatedWork W194065562 @default.
- W1496114544 hasRelatedWork W1985555722 @default.
- W1496114544 hasRelatedWork W1992532194 @default.
- W1496114544 hasRelatedWork W2049647270 @default.
- W1496114544 hasRelatedWork W2083289946 @default.
- W1496114544 hasRelatedWork W2748952813 @default.
- W1496114544 hasRelatedWork W3151053889 @default.