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- W1496164443 abstract "The aim of this study was to find epigenetic differences between obese sensitive and obese resistant phenotypes in an obesity sensitive mouse model. 88 C57BL/6J females were fed either a high-fat diet (HF, 60% kilocalories from fat) or a control diet (CT, 10% kilocalories from fat) for 10 weeks. 15 CT mice, 15 mice from the low (obesity resistant - HFR), and 15 high (obesity sensitive - HFS) weight extremes, respectively, were selected based on the heterogeneous weight gain of the group exposed to HF. Promoter DNA methylation (liver) was assessed between the 3 groups using methylated CpG islands amplification combined with microarrays (MCAM). Following statistical analysis for microarrays and gene ontology (GO) ranking we found that the HFR group is epigenetically similar to the CT, with 8 hyper-methylated and 73 hypo-methylated genes. The HFS group had 7,721 differentially methylated genes compared to the CT, with the majority being hyper-methylated. Also, we found higher methylation in the imprinted control region of the H19/Igf2 imprinted region, as determined by pyrosequencing, in the HFS group versus CT. In conclusion, the epigenomes of the obesity-resistant and control mice are similar, while the epigenome of the obesity-prone mice presents specific alterations. GO analysis revealed that such epigenetic alterations are grouped within functional classes related to key pathways involved in liver metabolism. Grant Funding Source: Nutrition Research Institute Research Funds" @default.
- W1496164443 created "2016-06-24" @default.
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- W1496164443 date "2014-04-01" @default.
- W1496164443 modified "2023-09-23" @default.
- W1496164443 title "Epigenetic changes in obesity (383.6)" @default.
- W1496164443 doi "https://doi.org/10.1096/fasebj.28.1_supplement.383.6" @default.
- W1496164443 hasPublicationYear "2014" @default.
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