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- W1496171921 abstract "This chapter provides an overview of the design of small-molecule ligands to target protein–protein interactions using both computational and experimental approaches. The chapter also discusses several successful examples on the design of small-molecule ligands to interrupt protein–protein interactions and the accomplishments and the challenges that remain in this area. Several laboratories show that it is feasible to design potent, nonpeptide, drug-like, small molecules, which inhibit protein–protein interactions. Computational virtual screening has played a critical role in the initial lead discovery associated with many of these compounds, and the computational structure-based approach is particularly effective in lead optimization. Computational methods that have been applied to the design of small-molecule inhibitors to disrupt protein–protein interactions are those that have developed and found successful in the design of enzyme inhibitors. As the understanding of the nature of protein–protein interactions accumulates, new computational methods will undoubtedly be developed to assist the design of small-molecule inhibitors, which target the large, shallow interface found in protein–protein complexes." @default.
- W1496171921 created "2016-06-24" @default.
- W1496171921 creator A5073754378 @default.
- W1496171921 creator A5090448113 @default.
- W1496171921 date "2006-01-01" @default.
- W1496171921 modified "2023-10-18" @default.
- W1496171921 title "Chapter 11 Recent Advances in Design of Small-Molecule Ligands to Target Protein–Protein Interactions" @default.
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- W1496171921 doi "https://doi.org/10.1016/s1574-1400(06)02011-1" @default.
- W1496171921 hasPublicationYear "2006" @default.