FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1496223818> ?p ?o ?g. }

• W1496223818 endingPage "213" @default.
• W1496223818 startingPage "207" @default.
• W1496223818 abstract "Neuromodulin (also designated P-57, GAP-43, B-50) is a major presynaptic substrate for protein kinase C. Phosphorylation of neuromodulin decreases its affinity for calmodulin, suggesting that neuromodulin may function to bind and concentrate calmodulin at specific sites within neurons, releasing calmodulin locally in response to phosphorylation by protein kinase C (Alexander, K. A., Cimler, B. M., Meier, K. E., and Storm, D. R. (1987) J. Biol. Chem. 262, 6108-6113). In the present study, we have constructed and characterized several mutant neuromodulins to demonstrate that the amino acid sequence 39-56 is required for calmodulin binding, and that this domain contains the sole in vitro protein kinase C phosphorylation site at serine 41. We also demonstrate that the adjacent phenylalanine 42, interacts hydrophobically with calmodulin. These hydrophobic interactions may be disrupted by the introduction of negative charge at serine 41, and thereby regulate the neuromodulin/calmodulin binding interactions. The sensitivity of the neuromodulin/calmodulin binding interaction to negative charge at serine 41 was determined by substitution of serine 41 with an aspartate or an asparagine residue. The asparagine mutant retained its affinity for calmodulin-Sepharose while the aspartate mutant did not adsorb to calmodulin-Sepharose. We conclude that protein kinase C phosphorylation of neuromodulin abolishes calmodulin binding by introducing negative charges within the calmodulin binding domain at a position adjacent to the phenylalanine." @default.
• W1496223818 created "2016-06-24" @default.
• W1496223818 creator A5005813264 @default.
• W1496223818 creator A5042815795 @default.
• W1496223818 creator A5050325620 @default.
• W1496223818 creator A5076960901 @default.
• W1496223818 creator A5085728727 @default.
• W1496223818 date "1991-01-01" @default.
• W1496223818 modified "2023-09-30" @default.
• W1496223818 title "Characterization of the calmodulin binding domain of neuromodulin. Functional significance of serine 41 and phenylalanine 42." @default.
• W1496223818 cites W1486939861 @default.
• W1496223818 cites W1509876279 @default.
• W1496223818 cites W1518396254 @default.
• W1496223818 cites W1592556850 @default.
• W1496223818 cites W1592692300 @default.
• W1496223818 cites W1641120577 @default.
• W1496223818 cites W1646353701 @default.
• W1496223818 cites W1775749144 @default.
• W1496223818 cites W1838152396 @default.
• W1496223818 cites W1968901680 @default.
• W1496223818 cites W1975551084 @default.
• W1496223818 cites W1985587671 @default.
• W1496223818 cites W1993619606 @default.
• W1496223818 cites W2001393222 @default.
• W1496223818 cites W2010254256 @default.
• W1496223818 cites W2010831794 @default.
• W1496223818 cites W2013760191 @default.
• W1496223818 cites W2030669640 @default.
• W1496223818 cites W2050217213 @default.
• W1496223818 cites W2061711561 @default.
• W1496223818 cites W2064864270 @default.
• W1496223818 cites W2076203826 @default.
• W1496223818 cites W2080823223 @default.
• W1496223818 cites W2084336840 @default.
• W1496223818 cites W2088002244 @default.
• W1496223818 cites W2088274057 @default.
• W1496223818 cites W2093689465 @default.
• W1496223818 cites W2095031817 @default.
• W1496223818 cites W2095774338 @default.
• W1496223818 cites W2101978320 @default.
• W1496223818 cites W2103920508 @default.
• W1496223818 cites W2138625446 @default.
• W1496223818 cites W2173578956 @default.
• W1496223818 cites W2322523131 @default.
• W1496223818 cites W2888511473 @default.
• W1496223818 doi "https://doi.org/10.1016/s0021-9258(18)52422-4" @default.
• W1496223818 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1824693" @default.
• W1496223818 hasPublicationYear "1991" @default.
• W1496223818 type Work @default.
• W1496223818 sameAs 1496223818 @default.
• W1496223818 citedByCount "152" @default.
• W1496223818 countsByYear W14962238182012 @default.
• W1496223818 countsByYear W14962238182013 @default.
• W1496223818 countsByYear W14962238182014 @default.
• W1496223818 countsByYear W14962238182016 @default.
• W1496223818 countsByYear W14962238182018 @default.
• W1496223818 countsByYear W14962238182021 @default.
• W1496223818 countsByYear W14962238182022 @default.
• W1496223818 countsByYear W14962238182023 @default.
• W1496223818 crossrefType "journal-article" @default.
• W1496223818 hasAuthorship W1496223818A5005813264 @default.
• W1496223818 hasAuthorship W1496223818A5042815795 @default.
• W1496223818 hasAuthorship W1496223818A5050325620 @default.
• W1496223818 hasAuthorship W1496223818A5076960901 @default.
• W1496223818 hasAuthorship W1496223818A5085728727 @default.
• W1496223818 hasBestOaLocation W14962238181 @default.
• W1496223818 hasConcept C171250308 @default.
• W1496223818 hasConcept C181199279 @default.
• W1496223818 hasConcept C185592680 @default.
• W1496223818 hasConcept C192562407 @default.
• W1496223818 hasConcept C2776414213 @default.
• W1496223818 hasConcept C2777431362 @default.
• W1496223818 hasConcept C2780841128 @default.
• W1496223818 hasConcept C29688787 @default.
• W1496223818 hasConcept C515207424 @default.
• W1496223818 hasConcept C51639874 @default.
• W1496223818 hasConcept C55493867 @default.
• W1496223818 hasConceptScore W1496223818C171250308 @default.
• W1496223818 hasConceptScore W1496223818C181199279 @default.
• W1496223818 hasConceptScore W1496223818C185592680 @default.
• W1496223818 hasConceptScore W1496223818C192562407 @default.
• W1496223818 hasConceptScore W1496223818C2776414213 @default.
• W1496223818 hasConceptScore W1496223818C2777431362 @default.
• W1496223818 hasConceptScore W1496223818C2780841128 @default.
• W1496223818 hasConceptScore W1496223818C29688787 @default.
• W1496223818 hasConceptScore W1496223818C515207424 @default.
• W1496223818 hasConceptScore W1496223818C51639874 @default.
• W1496223818 hasConceptScore W1496223818C55493867 @default.
• W1496223818 hasIssue "1" @default.
• W1496223818 hasLocation W14962238181 @default.
• W1496223818 hasOpenAccess W1496223818 @default.
• W1496223818 hasPrimaryLocation W14962238181 @default.
• W1496223818 hasRelatedWork W1496223818 @default.
• W1496223818 hasRelatedWork W1867182534 @default.
• W1496223818 hasRelatedWork W1981229103 @default.
• W1496223818 hasRelatedWork W2002445631 @default.
• W1496223818 hasRelatedWork W2021602785 @default.
• W1496223818 hasRelatedWork W2037521912 @default.

• next