Matches in SemOpenAlex for { <https://semopenalex.org/work/W1496292641> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W1496292641 abstract "Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of growth factors that bind to and activate the EGF receptor. HB-EGF is synthesized as a membrane-anchored protein (proHB-EGF), and then proteolytically cleaved, resulting in the mitogenically active soluble form. HB-EGF plays pivotal roles in pathophysiological processes such as development and cell proliferation. In this study, we developed an immuno-PCR system for the determination of soluble HB-EGF concentrations in human serum. Utilizing a monoclonal antibody with neutralizing activity against HB-EGF as a capture antibody resulted in increasing selectivity for an active form of HB-EGF in serum, and immuno-PCR system improved its sensitivity compared to the currently available methods. As a result of measurement of HB-EGF in 20 ovarian cancer patients and 20 healthy volunteers, ovarian cancer patients showed significantly higher concentrations than healthy volunteers (P< 0.05), which indicates that soluble HB-EGF detected by newly developed immuno-PCR system can be useful serological biomarkers such as a diagnostic biomarker for ovarian cancer, and a predictive and pharmacodynamic biomarker for anti-HB-EGF targeted therapies under development." @default.
- W1496292641 created "2016-06-24" @default.
- W1496292641 creator A5002582387 @default.
- W1496292641 creator A5002929730 @default.
- W1496292641 creator A5018707982 @default.
- W1496292641 creator A5026727407 @default.
- W1496292641 creator A5027308144 @default.
- W1496292641 creator A5066663160 @default.
- W1496292641 creator A5070148775 @default.
- W1496292641 creator A5042859074 @default.
- W1496292641 date "2012-01-01" @default.
- W1496292641 modified "2023-09-23" @default.
- W1496292641 title "Soluble heparin-binding EGF-like growth factor (HB-EGF) detected by newly developed immuno-PCR method is a clear-cut serological biomarker for ovarian cancer." @default.
- W1496292641 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3493029" @default.
- W1496292641 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23145209" @default.
- W1496292641 hasPublicationYear "2012" @default.
- W1496292641 type Work @default.
- W1496292641 sameAs 1496292641 @default.
- W1496292641 citedByCount "6" @default.
- W1496292641 countsByYear W14962926412013 @default.
- W1496292641 countsByYear W14962926412015 @default.
- W1496292641 countsByYear W14962926412019 @default.
- W1496292641 countsByYear W14962926412022 @default.
- W1496292641 crossrefType "journal-article" @default.
- W1496292641 hasAuthorship W1496292641A5002582387 @default.
- W1496292641 hasAuthorship W1496292641A5002929730 @default.
- W1496292641 hasAuthorship W1496292641A5018707982 @default.
- W1496292641 hasAuthorship W1496292641A5026727407 @default.
- W1496292641 hasAuthorship W1496292641A5027308144 @default.
- W1496292641 hasAuthorship W1496292641A5042859074 @default.
- W1496292641 hasAuthorship W1496292641A5066663160 @default.
- W1496292641 hasAuthorship W1496292641A5070148775 @default.
- W1496292641 hasConcept C121608353 @default.
- W1496292641 hasConcept C126322002 @default.
- W1496292641 hasConcept C153911025 @default.
- W1496292641 hasConcept C159048773 @default.
- W1496292641 hasConcept C159654299 @default.
- W1496292641 hasConcept C170493617 @default.
- W1496292641 hasConcept C203014093 @default.
- W1496292641 hasConcept C2775960820 @default.
- W1496292641 hasConcept C2776362946 @default.
- W1496292641 hasConcept C2780427987 @default.
- W1496292641 hasConcept C2781197716 @default.
- W1496292641 hasConcept C45189115 @default.
- W1496292641 hasConcept C542903549 @default.
- W1496292641 hasConcept C55493867 @default.
- W1496292641 hasConcept C71924100 @default.
- W1496292641 hasConcept C86803240 @default.
- W1496292641 hasConceptScore W1496292641C121608353 @default.
- W1496292641 hasConceptScore W1496292641C126322002 @default.
- W1496292641 hasConceptScore W1496292641C153911025 @default.
- W1496292641 hasConceptScore W1496292641C159048773 @default.
- W1496292641 hasConceptScore W1496292641C159654299 @default.
- W1496292641 hasConceptScore W1496292641C170493617 @default.
- W1496292641 hasConceptScore W1496292641C203014093 @default.
- W1496292641 hasConceptScore W1496292641C2775960820 @default.
- W1496292641 hasConceptScore W1496292641C2776362946 @default.
- W1496292641 hasConceptScore W1496292641C2780427987 @default.
- W1496292641 hasConceptScore W1496292641C2781197716 @default.
- W1496292641 hasConceptScore W1496292641C45189115 @default.
- W1496292641 hasConceptScore W1496292641C542903549 @default.
- W1496292641 hasConceptScore W1496292641C55493867 @default.
- W1496292641 hasConceptScore W1496292641C71924100 @default.
- W1496292641 hasConceptScore W1496292641C86803240 @default.
- W1496292641 hasLocation W14962926411 @default.
- W1496292641 hasOpenAccess W1496292641 @default.
- W1496292641 hasPrimaryLocation W14962926411 @default.
- W1496292641 hasRelatedWork W1511644480 @default.
- W1496292641 hasRelatedWork W1969963505 @default.
- W1496292641 hasRelatedWork W1982946667 @default.
- W1496292641 hasRelatedWork W1988669960 @default.
- W1496292641 hasRelatedWork W1992508309 @default.
- W1496292641 hasRelatedWork W1995879514 @default.
- W1496292641 hasRelatedWork W2001699167 @default.
- W1496292641 hasRelatedWork W2006813546 @default.
- W1496292641 hasRelatedWork W2041608376 @default.
- W1496292641 hasRelatedWork W2050713786 @default.
- W1496292641 hasRelatedWork W2126666758 @default.
- W1496292641 hasRelatedWork W2129292528 @default.
- W1496292641 hasRelatedWork W2130184385 @default.
- W1496292641 hasRelatedWork W2147672542 @default.
- W1496292641 hasRelatedWork W2148836570 @default.
- W1496292641 hasRelatedWork W2149590321 @default.
- W1496292641 hasRelatedWork W2345928136 @default.
- W1496292641 hasRelatedWork W2348593274 @default.
- W1496292641 hasRelatedWork W2800266313 @default.
- W1496292641 hasRelatedWork W3033387464 @default.
- W1496292641 isParatext "false" @default.
- W1496292641 isRetracted "false" @default.
- W1496292641 magId "1496292641" @default.
- W1496292641 workType "article" @default.