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• W1496321548 abstract "Despite the high prevalence of non-motor symptoms across a range of Parkinson's disease (PD) severity, there is still a paucity of well-designed and validated instruments. Scales for cognition and mood are perhaps the most advanced. There is more limited experience with scales for psychosis in PD. Scales for autonomic dysfunction and sleep are even less well developed. There is a pressing need for standardization and validation of these instruments to assess the impact of treatments on these domains. Initial experience with scales not directed at specific domains of impairment (e.g., mood, cognition) but focused on disability and health-related quality-of-life can be responsive to treatment effects and have utility in clinical trials. The data collected to date suggest that non-motor symptoms contribute heavily to the worsening of health-related quality-of-life in PD patients. A major challenge for the near future is to define the natural rate of progression of these features and to develop reliable, validated instruments to assess these features that are generally accepted and used across multiple centers for evaluating the potential value of new study interventions. New long-term study designs which capture cumulative disability related to both motor and non-motor features are likely to be increasingly more widely employed." @default.
• W1496321548 created "2016-06-24" @default.
• W1496321548 creator A5030324367 @default.
• W1496321548 date "2011-06-27" @default.
• W1496321548 modified "2023-10-18" @default.
• W1496321548 title "Clinical Trial Measures of the Non‐Motor Features of Parkinson's Disease" @default.
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• W1496321548 doi "https://doi.org/10.1002/9781444397970.ch11" @default.
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