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- W1496341714 abstract "OBJECTIVE: Evaluate the prevalence of neuropsychiatric symptoms (NPS) within cognitive subtypes and weight groups of Mild Cognitive Impairment (MCI).BACKGROUND: In MCI, new-onset changes in mood and behavior (NPS) predict an increased likelihood of developing AD. Obesity has recently also been implicated as a risk factor for dementia and may further increase the severity of MCI when combined with NPS. Yet these non-cognitive characteristics have not been accorded much attention as potential risk factors in MCI. Thus, the prevalence of NPS was investigated within cognitive subtypes: amnestic (aMCI), multi-domain (mdMCI) and non-amnestic (naMCI), as well as weight groups categorized by body mass index (BMI).DESIGN/METHODS: 101 MCI subjects with no history of stroke or other neurological disorder were examined. A neuropsychological assessment battery was administered to determine MCI subtype. Subjects were designated as normal weight (NW; BMI 18.5- 24.9), overweight (OW; BMI 25 - 29.9) or obese (OB; BMI 蠅 30). The presence and severity of NPS was measured using the Neuropsychiatric Inventory Questionnaire (NPIQ); and further quantification of depressive symptoms (DS) was obtained with the Geriatric Depression Scale (GDS).RESULTS: On the NPIQ, DS and nighttime behaviors were the most frequently reported for the whole MCI group (48%), with DS rated as the most severe NPS. Interestingly, the most frequent symptom differed by weight, with appetite changes highest among NW (35%) and DS (33%) among OB subgroups. In addition, the prevalence of NPS differed within BMI group and cognitive subtype: compared to NW, the OB had a significantly higher prevalence of NPS on the NPI-Q (p = .01), and across cognitive subtypes, there was a significant difference in GDS scores (p = 0.04, F = 3.36) between the aMCI and mdMCI subtypes.CONCLUSION: Early behavioral changes in MCI were highest among mdMCI and OB subjects. Continuing work focuses on imaging correlates of behavioral changes in cognitive subtypes and BMI groups in MCI, and longitudinal outcomes. Disclosure: Dr. Hannah has nothing to disclose. Dr. Bozoki has received research support from Elan Corporation, and Wyeth Pharmaceuticals." @default.
- W1496341714 created "2016-06-24" @default.
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- W1496341714 date "2014-04-08" @default.
- W1496341714 modified "2023-09-26" @default.
- W1496341714 title "Mild Cognitive Impairment: Neuropsychiatric Symptom Prevalence Within Cognitive Subtypes And Obesity (P2.177)" @default.
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