Matches in SemOpenAlex for { <https://semopenalex.org/work/W1496355881> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W1496355881 endingPage "3369" @default.
- W1496355881 startingPage "3365" @default.
- W1496355881 abstract "The disposition of (+) and (-) primaquine (PQ) was studied in the isolated perfused rat liver (IPRL) preparation following a bolus dose (2.0 mg diphosphate salt; N = 6) of each enantiomer. Perfusate plasma concentrations of PQ and the carboxylic acid metabolite (PQm) were determined using previously reported methods. To enable the simultaneous measurement of PQ and PQm in bile a selective and reproducible HPLC assay was developed. Clearance of (-)PQ (8.8 +/- 2.9 ml min-1) was significantly greater than that of (+)PQ (5.5 +/- 1.5 ml min-1) and the apparent volumes of distribution of (-)PQ (606 +/- 182 ml) and (+)PQ (930 +/- 171 ml) were significantly different. Stereoselectivity in the hepatic elimination efficiency was manifest as a significant reduction in half-life (-)PQ 54 +/- 29 min; (+)PQ 123 +/- 33 min) and smaller area under the curve to infinity (-)PQ 254 +/- 96 micrograms ml-1.min, (+)PQ 387 +/- 108 micrograms ml-1.min) for (-)PQ when compared with (+)PQ. A significantly greater peak concentration of PQm was achieved following administration of (-)PQ (0.61 +/- 0.26 micrograms ml-1.min) than (+)PQ (0.19 +/- 0.09 micrograms ml-1). There was no difference between the sum of the areas under the curve to 4 hr for (+) and (-)PQ and the corresponding carboxylic acid metabolite (322 +/- 64 micrograms ml-1 and 317 +/- 75 micrograms ml min-1 respectively). There was no difference in the biliary clearance of (+) and (-)PQ (0.08 +/- 0.02 ml min-1 and 0.14 +/- 0.10 ml min-1 respectively) or the corresponding carboxylic acid metabolites (0.24 +/- 0.13 ml min-1 and 0.29 +/- 0.09 ml min-1). These results strongly suggest stereoselective formation of the carboxylic acid metabolite of primaquine. The significant increase in the volume of distribution of (+)PQ suggests the enantiomer has either an increased affinity for binding sites within the liver and/or erythrocytes or a decreased affinity for circulating perfusate albumin." @default.
- W1496355881 created "2016-06-24" @default.
- W1496355881 creator A5008381642 @default.
- W1496355881 creator A5009537610 @default.
- W1496355881 creator A5042765093 @default.
- W1496355881 creator A5046120879 @default.
- W1496355881 creator A5061252066 @default.
- W1496355881 date "1987-10-01" @default.
- W1496355881 modified "2023-09-27" @default.
- W1496355881 title "The disposition of primaquine in the isolated perfused rat liver" @default.
- W1496355881 cites W133354911 @default.
- W1496355881 cites W1979774888 @default.
- W1496355881 cites W1981241430 @default.
- W1496355881 cites W1988277487 @default.
- W1496355881 cites W2002603564 @default.
- W1496355881 cites W2038648856 @default.
- W1496355881 cites W2042938614 @default.
- W1496355881 cites W2049550634 @default.
- W1496355881 cites W2065776977 @default.
- W1496355881 cites W2085597837 @default.
- W1496355881 cites W2089897660 @default.
- W1496355881 cites W2149460783 @default.
- W1496355881 cites W2401910378 @default.
- W1496355881 cites W30895175 @default.
- W1496355881 doi "https://doi.org/10.1016/0006-2952(87)90312-1" @default.
- W1496355881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3675598" @default.
- W1496355881 hasPublicationYear "1987" @default.
- W1496355881 type Work @default.
- W1496355881 sameAs 1496355881 @default.
- W1496355881 citedByCount "17" @default.
- W1496355881 countsByYear W14963558812014 @default.
- W1496355881 countsByYear W14963558812015 @default.
- W1496355881 countsByYear W14963558812019 @default.
- W1496355881 countsByYear W14963558812022 @default.
- W1496355881 countsByYear W14963558812023 @default.
- W1496355881 crossrefType "journal-article" @default.
- W1496355881 hasAuthorship W1496355881A5008381642 @default.
- W1496355881 hasAuthorship W1496355881A5009537610 @default.
- W1496355881 hasAuthorship W1496355881A5042765093 @default.
- W1496355881 hasAuthorship W1496355881A5046120879 @default.
- W1496355881 hasAuthorship W1496355881A5061252066 @default.
- W1496355881 hasConcept C112705442 @default.
- W1496355881 hasConcept C179998833 @default.
- W1496355881 hasConcept C185592680 @default.
- W1496355881 hasConcept C203014093 @default.
- W1496355881 hasConcept C2776793103 @default.
- W1496355881 hasConcept C2777425658 @default.
- W1496355881 hasConcept C2777477808 @default.
- W1496355881 hasConcept C2778048844 @default.
- W1496355881 hasConcept C43617362 @default.
- W1496355881 hasConcept C55493867 @default.
- W1496355881 hasConcept C86803240 @default.
- W1496355881 hasConcept C98274493 @default.
- W1496355881 hasConceptScore W1496355881C112705442 @default.
- W1496355881 hasConceptScore W1496355881C179998833 @default.
- W1496355881 hasConceptScore W1496355881C185592680 @default.
- W1496355881 hasConceptScore W1496355881C203014093 @default.
- W1496355881 hasConceptScore W1496355881C2776793103 @default.
- W1496355881 hasConceptScore W1496355881C2777425658 @default.
- W1496355881 hasConceptScore W1496355881C2777477808 @default.
- W1496355881 hasConceptScore W1496355881C2778048844 @default.
- W1496355881 hasConceptScore W1496355881C43617362 @default.
- W1496355881 hasConceptScore W1496355881C55493867 @default.
- W1496355881 hasConceptScore W1496355881C86803240 @default.
- W1496355881 hasConceptScore W1496355881C98274493 @default.
- W1496355881 hasIssue "20" @default.
- W1496355881 hasLocation W14963558811 @default.
- W1496355881 hasLocation W14963558812 @default.
- W1496355881 hasOpenAccess W1496355881 @default.
- W1496355881 hasPrimaryLocation W14963558811 @default.
- W1496355881 hasRelatedWork W134413669 @default.
- W1496355881 hasRelatedWork W1970888742 @default.
- W1496355881 hasRelatedWork W1973892552 @default.
- W1496355881 hasRelatedWork W1999301148 @default.
- W1496355881 hasRelatedWork W2037510280 @default.
- W1496355881 hasRelatedWork W2085597837 @default.
- W1496355881 hasRelatedWork W2089172952 @default.
- W1496355881 hasRelatedWork W2406364491 @default.
- W1496355881 hasRelatedWork W2770888081 @default.
- W1496355881 hasRelatedWork W610504060 @default.
- W1496355881 hasVolume "36" @default.
- W1496355881 isParatext "false" @default.
- W1496355881 isRetracted "false" @default.
- W1496355881 magId "1496355881" @default.
- W1496355881 workType "article" @default.