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- W1496438553 abstract "Female rats were given implants of estrone pellets to study mammary tumor development and growth. In the latter half of the induction period but before mammary tumors had developed additional hormones (estrogen testosterone growth hormone or progesterone) were administered. In other groups hormonal treatment was not instituted until the tumors were well developed. Oophorectomy was performed at the time of the initial implantation of the estrone pellet or later during the induction period (200 days). Adrenalectomies were done 200 days after pellet administration and hypophysectomies were performed at 125 days. Administration of additional estrogen reduced the latent period for mammary tumor induction following the implantation but did not alter the course of established tumors. Testosterone growth hormone or progesterone increased the latent period and caused temporary regression of the established tumors. Ovariectomy and adrenalectomy prolonged the time required for tumor induction. Tumors failed to develop in hypophysectomized animals." @default.
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- W1496438553 date "1964-08-01" @default.
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- W1496438553 title "Estrone-induced Mammary Tumors in the Rat II. Effect of Alterations in the Hormonal Environment on Tumor Induction, Behavior, and Growth" @default.
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