Matches in SemOpenAlex for { <https://semopenalex.org/work/W1496453114> ?p ?o ?g. }
- W1496453114 abstract "The peptide hormone insulin is secreted from pancreatic β-cells, binds to cell surface receptors, and exerts a broad spectrum of anabolic effects in multiple tissues. In mediating its pleiotrophic actions, insulin engages multiple signal transduction, pathways that affect the expression and posttranslational modification of proteins, and regulates enzymatic pathways, subcellular protein localization, and the activation state of membrane transport systems. There are three major steps that provide for divergence of insulin signal transduction, leading to different functional effects: (i) the family of insulin receptor substrate (IRS) docking molecules, (ii) activation of phosphatidylinositide 3 (PI-3) kinase, and (iii) activation of Akt/protein kinase B (PKB). Stimulation of the glucose transport system involves activation of two parallel pathways, the IRS/PI-3 kinase pathway (resulting in activation of Akt/PKB and PKC-λ/ζ) and the CAP/Cbl/TC10 pathway, that then interact with systems regulating trafficking of GLUT-4-containing vesicles and the cytoskeleton. Furthermore, multiple mechanisms modulate insulin signal transduction by affecting the serine/threonine phosphorylation state of tyrosine kinase substrates and phosphoinositides, and the tyrosine phosphorylation state of insulin receptors and IRS molecules. Thus, promulgation of the insulin action is most accurately viewed as a flexible pattern of network interactions involving a web of signal molecule cascades and effector systems. Complex patterns of interactions among signal and effector systems allow for greater plasticity in adaptive responses, and present an increasing number of targets for therapeutic intervention in treating human insulin resistance.Keywords:insulin signaling;insulin action;insulin receptor;insulin receptor substrate;phosphatidylinositide-3 kinase;Akt/protein kinase B;glucose transport;glucose transporter;GLUT-4" @default.
- W1496453114 created "2016-06-24" @default.
- W1496453114 creator A5047565815 @default.
- W1496453114 date "2004-03-15" @default.
- W1496453114 modified "2023-10-14" @default.
- W1496453114 title "Mechanisms of Insulin Signal Transduction" @default.
- W1496453114 cites W1491267816 @default.
- W1496453114 cites W1523158326 @default.
- W1496453114 cites W1547466369 @default.
- W1496453114 cites W1555409852 @default.
- W1496453114 cites W1562862680 @default.
- W1496453114 cites W1570362997 @default.
- W1496453114 cites W1599234530 @default.
- W1496453114 cites W1599478288 @default.
- W1496453114 cites W1665938856 @default.
- W1496453114 cites W1668039320 @default.
- W1496453114 cites W1678800844 @default.
- W1496453114 cites W1697523131 @default.
- W1496453114 cites W1773423646 @default.
- W1496453114 cites W1905082515 @default.
- W1496453114 cites W1963734058 @default.
- W1496453114 cites W1964352211 @default.
- W1496453114 cites W1964434806 @default.
- W1496453114 cites W1969134590 @default.
- W1496453114 cites W1970471141 @default.
- W1496453114 cites W1970761589 @default.
- W1496453114 cites W1971762417 @default.
- W1496453114 cites W1972172786 @default.
- W1496453114 cites W1972239225 @default.
- W1496453114 cites W1972590376 @default.
- W1496453114 cites W1974075629 @default.
- W1496453114 cites W1975299036 @default.
- W1496453114 cites W1977011921 @default.
- W1496453114 cites W1977472414 @default.
- W1496453114 cites W1977795081 @default.
- W1496453114 cites W1978046076 @default.
- W1496453114 cites W1979147887 @default.
- W1496453114 cites W1981043027 @default.
- W1496453114 cites W1981696607 @default.
- W1496453114 cites W1984607512 @default.
- W1496453114 cites W1985113364 @default.
- W1496453114 cites W1985302300 @default.
- W1496453114 cites W1985389068 @default.
- W1496453114 cites W1986758681 @default.
- W1496453114 cites W1988370020 @default.
- W1496453114 cites W1988870963 @default.
- W1496453114 cites W1989294105 @default.
- W1496453114 cites W1991710558 @default.
- W1496453114 cites W1993836723 @default.
- W1496453114 cites W1997460544 @default.
- W1496453114 cites W1997732080 @default.
- W1496453114 cites W1998138065 @default.
- W1496453114 cites W1999447199 @default.
- W1496453114 cites W2000312245 @default.
- W1496453114 cites W2001814712 @default.
- W1496453114 cites W2002127663 @default.
- W1496453114 cites W2003659422 @default.
- W1496453114 cites W2004501108 @default.
- W1496453114 cites W2004920315 @default.
- W1496453114 cites W2008632158 @default.
- W1496453114 cites W2011001359 @default.
- W1496453114 cites W2013617213 @default.
- W1496453114 cites W2014064711 @default.
- W1496453114 cites W2018917333 @default.
- W1496453114 cites W2021632088 @default.
- W1496453114 cites W2024942502 @default.
- W1496453114 cites W2027360957 @default.
- W1496453114 cites W2028782957 @default.
- W1496453114 cites W2031504013 @default.
- W1496453114 cites W2031610264 @default.
- W1496453114 cites W2031637294 @default.
- W1496453114 cites W2033330574 @default.
- W1496453114 cites W2033429522 @default.
- W1496453114 cites W2034046497 @default.
- W1496453114 cites W2038081709 @default.
- W1496453114 cites W2039350631 @default.
- W1496453114 cites W2040621132 @default.
- W1496453114 cites W2042917756 @default.
- W1496453114 cites W2044455015 @default.
- W1496453114 cites W2046869727 @default.
- W1496453114 cites W2046933694 @default.
- W1496453114 cites W2046933787 @default.
- W1496453114 cites W2047137800 @default.
- W1496453114 cites W2050092688 @default.
- W1496453114 cites W2055029805 @default.
- W1496453114 cites W2058138221 @default.
- W1496453114 cites W2059692699 @default.
- W1496453114 cites W2061617907 @default.
- W1496453114 cites W2062596469 @default.
- W1496453114 cites W2063858796 @default.
- W1496453114 cites W2064529356 @default.
- W1496453114 cites W2064801081 @default.
- W1496453114 cites W2067799923 @default.
- W1496453114 cites W2068063638 @default.
- W1496453114 cites W2070119291 @default.
- W1496453114 cites W2070726224 @default.
- W1496453114 cites W2070732456 @default.
- W1496453114 cites W2071839580 @default.
- W1496453114 cites W2073378157 @default.
- W1496453114 cites W2075645766 @default.