FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1496603101> ?p ?o ?g. }

• W1496603101 endingPage "70" @default.
• W1496603101 startingPage "1962" @default.
• W1496603101 abstract "To determine whether adrenomedullin (ADM), a vasorelaxant peptide is produced and secreted by human retinal pigment epithelial (RPE) cells, whether ADM expression is regulated by inflammatory cytokines and a growth factor, and whether ADM has proliferative effects on these cells.Production and secretion of ADM by cultured human RPE cells were examined by Northern blot analysis and radioimmunoassay. Regulation of the ADM expression by basic fibroblast growth factor, interferon (IFN)-gamma, tumor necrosis factor-alpha, interleukin (IL)1beta, or all-trans-retinoic acid was studied. In addition, proliferative effects of ADM on human RPE cells were examined by modified 3-(4,5-dimetylthiazol-2-yl)2,5-diphenyltetrazolium bromide (MTT) assay.ADM mRNA was expressed constitutively in all three human RPE cell lines (F-0202, D407, and ARPE-19) examined. Immunoreactive ADM was detected in the cultured media by radioimmunoassay. Sephadex G-50 column chromatography of the cultured medium showed a single peak eluting in the position of ADM-(1-52). Treatment with IFN-gamma or IL-beta increased ADM mRNA levels and immunoreactive-ADM levels in the medium in dose- and time-dependent manners in ARPE-19 cells. Exogenously added ADM increased the number of F-0202 cells and ARPE-19 cells, and the treatment with ADM antibody or ADM-(22-52) (an ADM antagonist) decreased it.Human RPE cells produced and secreted ADM. IFN-gamma and IL-1beta induced ADM expression in ARPE-19 cells. Furthermore, ADM stimulated proliferation of RPE cells. These results raise the possibility that ADM is related to the pathophysiology of some inflammatory and proliferative ocular diseases." @default.
• W1496603101 created "2016-06-24" @default.
• W1496603101 creator A5001915429 @default.
• W1496603101 creator A5027654292 @default.
• W1496603101 creator A5039327799 @default.
• W1496603101 creator A5042175811 @default.
• W1496603101 creator A5058115734 @default.
• W1496603101 creator A5079198093 @default.
• W1496603101 creator A5091608515 @default.
• W1496603101 date "2000-06-01" @default.
• W1496603101 modified "2023-09-25" @default.
• W1496603101 title "Adrenomedullin in cultured human retinal pigment epithelial cells." @default.
• W1496603101 cites W1492896001 @default.
• W1496603101 cites W1504900014 @default.
• W1496603101 cites W1517718326 @default.
• W1496603101 cites W1531951330 @default.
• W1496603101 cites W1596264327 @default.
• W1496603101 cites W1714595 @default.
• W1496603101 cites W1965121261 @default.
• W1496603101 cites W19734096 @default.
• W1496603101 cites W1975043689 @default.
• W1496603101 cites W1977895630 @default.
• W1496603101 cites W1980985994 @default.
• W1496603101 cites W1981466964 @default.
• W1496603101 cites W1981492597 @default.
• W1496603101 cites W1981636103 @default.
• W1496603101 cites W1983728153 @default.
• W1496603101 cites W1985488507 @default.
• W1496603101 cites W1985833604 @default.
• W1496603101 cites W1998219965 @default.
• W1496603101 cites W2003978655 @default.
• W1496603101 cites W2018062213 @default.
• W1496603101 cites W2019378063 @default.
• W1496603101 cites W2022146507 @default.
• W1496603101 cites W2023178307 @default.
• W1496603101 cites W2023541036 @default.
• W1496603101 cites W2025699735 @default.
• W1496603101 cites W2026726871 @default.
• W1496603101 cites W2027578274 @default.
• W1496603101 cites W2028064396 @default.
• W1496603101 cites W2029260226 @default.
• W1496603101 cites W2035589747 @default.
• W1496603101 cites W2039711337 @default.
• W1496603101 cites W2046572176 @default.
• W1496603101 cites W2046787212 @default.
• W1496603101 cites W2047393488 @default.
• W1496603101 cites W2051372947 @default.
• W1496603101 cites W2060000931 @default.
• W1496603101 cites W2070125125 @default.
• W1496603101 cites W2071000520 @default.
• W1496603101 cites W2072198264 @default.
• W1496603101 cites W2076034382 @default.
• W1496603101 cites W2076758633 @default.
• W1496603101 cites W2076935123 @default.
• W1496603101 cites W2078164089 @default.
• W1496603101 cites W2084155130 @default.
• W1496603101 cites W2084353638 @default.
• W1496603101 cites W2085541943 @default.
• W1496603101 cites W2086889806 @default.
• W1496603101 cites W2086978329 @default.
• W1496603101 cites W2087349962 @default.
• W1496603101 cites W2092419989 @default.
• W1496603101 cites W2092448118 @default.
• W1496603101 cites W2093471074 @default.
• W1496603101 cites W2111112233 @default.
• W1496603101 cites W2114918609 @default.
• W1496603101 cites W2170616939 @default.
• W1496603101 cites W4177524 @default.
• W1496603101 cites W91805030 @default.
• W1496603101 cites W166111696 @default.
• W1496603101 cites W2161842193 @default.
• W1496603101 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10845623" @default.
• W1496603101 hasPublicationYear "2000" @default.
• W1496603101 type Work @default.
• W1496603101 sameAs 1496603101 @default.
• W1496603101 citedByCount "21" @default.
• W1496603101 countsByYear W14966031012012 @default.
• W1496603101 countsByYear W14966031012016 @default.
• W1496603101 countsByYear W14966031012017 @default.
• W1496603101 countsByYear W14966031012018 @default.
• W1496603101 crossrefType "journal-article" @default.
• W1496603101 hasAuthorship W1496603101A5001915429 @default.
• W1496603101 hasAuthorship W1496603101A5027654292 @default.
• W1496603101 hasAuthorship W1496603101A5039327799 @default.
• W1496603101 hasAuthorship W1496603101A5042175811 @default.
• W1496603101 hasAuthorship W1496603101A5058115734 @default.
• W1496603101 hasAuthorship W1496603101A5079198093 @default.
• W1496603101 hasAuthorship W1496603101A5091608515 @default.
• W1496603101 hasConcept C126322002 @default.
• W1496603101 hasConcept C134018914 @default.
• W1496603101 hasConcept C153911025 @default.
• W1496603101 hasConcept C170493617 @default.
• W1496603101 hasConcept C176685330 @default.
• W1496603101 hasConcept C17991360 @default.
• W1496603101 hasConcept C185592680 @default.
• W1496603101 hasConcept C2775960820 @default.
• W1496603101 hasConcept C2777152744 @default.
• W1496603101 hasConcept C2777587049 @default.

• next