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• W1496610555 abstract "Epileptologists have now at their disposal a variety of tools for investigating human brain functions. Among the technologies of non-invasive functional imaging that have flowered in the last years, two techniques became particularly popular: the electroencephalogram (EEG) which records electrical voltages from the electrodes placed on the scalp and functional magnetic resonance imaging (fMRI) which records magnetization changes due to variations in blood oxygenation. Each of these methods have its own advantages and disadvantages and no single method is best suited for all experimental and clinical conditions. EEG is a long-established tool for the non-invasive brain investigation characterized by the high temporal resolution (measured in milliseconds) but very low spatial resolution (measured in square centimetres). In contrast, fMRI provides good spatial resolution (measured in square millimetres) but relatively poor temporal resolution (measured in seconds). Combining EEG and fMRI provides integration of information that results in an enhanced view of the phenomena of interest. This fusion of information is particularly useful in the context of the study of the epileptic disorders. The EEG was used in the study of epilepsy since it was discovered and it remains nowadays the gold-standard for the diagnosis of epilepsy, the classification of the seizures types and the localization of the generators of the epileptic activity. The EEG measurements recorded on the scalp is visually inspected by the neurophysiologists in order to detect any epileptic pattern such as spikes, spike-wave bursts, seizures, etc. and to diagnose the epilepsy. From a spatial point of view only a topographic localization of the generators of ictal and interictal activity is possible. Because of poor spatial resolution of the EEG technique, in many cases it means just a lateralization of the generators and not their precise localization. fMRI, first demonstrated in 1990, is a technique that, through the blood oxygen level dependent (BOLD) effect, allows the localization of brain areas in which there is a variation of the level of neuronal activity during an experimental condition compared to a control condition. fMRI is mostly used in the study of sensory, motor and cognitive functions, in which the experimental condition differs from the control condition in a way that is controlled by the experimenter. In the context of epilepsy or spontaneous physiological changes in brain state, one can consider the control condition at the time when the EEG is at baseline and the experimental condition to occur in presence of endogenous electrophysiological phenomena such as an epileptic discharge or a sleep spindle. To define" @default.
• W1496610555 created "2016-06-24" @default.
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• W1496610555 date "2011-09-15" @default.
• W1496610555 modified "2023-10-02" @default.
• W1496610555 title "EEG-fMRI Multimodal Integration for Epilepsy Research" @default.
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• W1496610555 doi "https://doi.org/10.5772/21891" @default.
• W1496610555 hasPublicationYear "2011" @default.
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