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- W1496634879 endingPage "4984" @default.
- W1496634879 startingPage "4967" @default.
- W1496634879 abstract "Part of our ocean's richness comes from its extensive history of supporting life, resulting in a highly diverse ecological system. To date, over 250,000 species of marine organisms have been identified, but it is speculated that the actual number of marine species exceeds one million, including several hundreds of millions of species of marine microorganisms. Past studies suggest that approximately 70% of all deep-sea microorganisms, gorgonians, and sea sponges produce secondary metabolites with anti-cancer activities. Recently, novel FDA-approved drugs derived from marine sponges have been shown to reduce metastatic breast cancer, malignant lymphoma, and Hodgkin's disease. Despite the fact that many marine natural products have been shown to possess a good inhibition potential against most of the cancer-related cell signaling pathways, only a few marine natural products have been shown to target JAK/STAT signaling. In the present paper, we describe the JAK/STAT signaling pathways found in marine organisms, before elaborating on the recent advances in the field of STAT inhibition by marine natural products and the potential application in anti-cancer drug discovery." @default.
- W1496634879 created "2016-06-24" @default.
- W1496634879 creator A5018593253 @default.
- W1496634879 creator A5051233094 @default.
- W1496634879 creator A5064605300 @default.
- W1496634879 date "2015-08-07" @default.
- W1496634879 modified "2023-09-25" @default.
- W1496634879 title "Signal Transducers and Activators of Transcription (STAT) Regulatory Networks in Marine Organisms: From Physiological Observations towards Marine Drug Discovery" @default.
- W1496634879 cites W1483308173 @default.
- W1496634879 cites W1793709550 @default.
- W1496634879 cites W1816880077 @default.
- W1496634879 cites W1862470254 @default.
- W1496634879 cites W1964815717 @default.
- W1496634879 cites W1965694039 @default.
- W1496634879 cites W1969396690 @default.
- W1496634879 cites W1973309311 @default.
- W1496634879 cites W1974670429 @default.
- W1496634879 cites W1975560267 @default.
- W1496634879 cites W1978565949 @default.
- W1496634879 cites W1986625462 @default.
- W1496634879 cites W1990298241 @default.
- W1496634879 cites W1993491755 @default.
- W1496634879 cites W1995722403 @default.
- W1496634879 cites W1995997868 @default.
- W1496634879 cites W1996702249 @default.
- W1496634879 cites W2000380799 @default.
- W1496634879 cites W2001546125 @default.
- W1496634879 cites W2002220979 @default.
- W1496634879 cites W2004068229 @default.
- W1496634879 cites W2006571307 @default.
- W1496634879 cites W2007687296 @default.
- W1496634879 cites W2011653766 @default.
- W1496634879 cites W2015597206 @default.
- W1496634879 cites W2016098671 @default.
- W1496634879 cites W2019343036 @default.
- W1496634879 cites W2023889129 @default.
- W1496634879 cites W2027197335 @default.
- W1496634879 cites W2029275361 @default.
- W1496634879 cites W2030112707 @default.
- W1496634879 cites W2033336766 @default.
- W1496634879 cites W2034974668 @default.
- W1496634879 cites W2041187882 @default.
- W1496634879 cites W2043803403 @default.
- W1496634879 cites W2045584477 @default.
- W1496634879 cites W2051190854 @default.
- W1496634879 cites W2052929044 @default.
- W1496634879 cites W2054529141 @default.
- W1496634879 cites W2060570452 @default.
- W1496634879 cites W2061558240 @default.
- W1496634879 cites W2062155409 @default.
- W1496634879 cites W2062505071 @default.
- W1496634879 cites W2064276033 @default.
- W1496634879 cites W2064840117 @default.
- W1496634879 cites W2064944074 @default.
- W1496634879 cites W2065993983 @default.
- W1496634879 cites W2066816366 @default.
- W1496634879 cites W2067278945 @default.
- W1496634879 cites W2068155633 @default.
- W1496634879 cites W2072171359 @default.
- W1496634879 cites W2073742636 @default.
- W1496634879 cites W2075749149 @default.
- W1496634879 cites W2081079409 @default.
- W1496634879 cites W2083802827 @default.
- W1496634879 cites W2087527164 @default.
- W1496634879 cites W2088561077 @default.
- W1496634879 cites W2088685468 @default.
- W1496634879 cites W2094256260 @default.
- W1496634879 cites W2098411470 @default.
- W1496634879 cites W2100508152 @default.
- W1496634879 cites W2107965719 @default.
- W1496634879 cites W2109801007 @default.
- W1496634879 cites W2110124208 @default.
- W1496634879 cites W2112200517 @default.
- W1496634879 cites W2116281685 @default.
- W1496634879 cites W2119214893 @default.
- W1496634879 cites W2120431726 @default.
- W1496634879 cites W2121785674 @default.
- W1496634879 cites W2128617253 @default.
- W1496634879 cites W2131491521 @default.
- W1496634879 cites W2139857335 @default.
- W1496634879 cites W2141549675 @default.
- W1496634879 cites W2142075224 @default.
- W1496634879 cites W2143624825 @default.
- W1496634879 cites W2144241909 @default.
- W1496634879 cites W2144524391 @default.
- W1496634879 cites W2153737617 @default.
- W1496634879 cites W2163685688 @default.
- W1496634879 cites W2170149467 @default.
- W1496634879 cites W2171513236 @default.
- W1496634879 cites W2173560213 @default.
- W1496634879 cites W2318332039 @default.
- W1496634879 cites W2398054895 @default.
- W1496634879 cites W2413830929 @default.
- W1496634879 cites W2916217306 @default.
- W1496634879 cites W2951294297 @default.
- W1496634879 doi "https://doi.org/10.3390/md13084967" @default.
- W1496634879 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4557010" @default.
- W1496634879 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26262624" @default.