FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1496663485> ?p ?o ?g. }

• W1496663485 endingPage "76" @default.
• W1496663485 startingPage "1" @default.
• W1496663485 abstract "The primary central nervous system lymphoma (PCSNL), as one of the uncommon extranodal lymphomas, has been recently paid more attention especially for its increasing incidence, unsatisfactory therapy and poor prognosis. MGMT is one of the most important factors determining drug resistance while Ku80 determining radiosensitivity, the expression of MGMT and Ku80 in PCNSL remains unclear. The aim of our study was to detect the expression of MGMT and Ku80 on PCNSL by IHC staining and to evaluate the relationship between Ku80, MGMT expression level and clinical outcomes, thus determine whether these immunophenotypes were prognostic factors in PCNSL. 49 patients with PCNSL were included in this retrospective study. The expression of Ku80 and MGMT in tumor samples was determined by immunohistochemistry using the Ku80 and MGMT monoclonal mouse antihuman antibody. One thousand neoplastic cells per specimen were counted. On the basis of the percentages of positive cells in the tumors, these tumors were defined as low Ku80 expression or low MGMT expression when there are no or fewer than 50% positive cells, and high expression when positive rate was more than 50%. The expression levels were than compared to the clinical data and statistical analyzed. The mean expression level of Ku80 and MGMT in 49 PCNSL were 64.1±24.5 and 51.3±29.5 respectively. A correlation was found between these two proteins expressions (r=0.311, P=0.029). A significant difference in Ku80 expression could be found between age 0.05). Kaplan-Meier analysis revealed that patients who showed a high Ku80 expression had a significantly shorter median survival time (MST) than patients who had low Ku80 expression (55.3 months vs. 80.4 months; P =0.036). This could not be observed for the MGMT expression. Patients’ age, tumor location, treatment protocol, alkylating agents were significantly related with prognosis in PCNSL (P<0.05). The results of this study show that the expression of Ku80 and MGMT can be found in the majority of PCNSLs, although without statistically difference compared with their expressions in secondary CNS lymphoma. It is the first time to detect the expression of Ku80 proteins in PCNSL. Ku80 expression was a positive predictor for survival in this study. Immunohistochemical detection of MGMT does not correlate with overall survival, and cannot be used as a prognostic factor. With Ku80 we can add another predictor to evaluate the prognosis in patients with PCSNL and confirm the relevance of patient age and tumor location at the time of diagnosis in the prognosis of PCSNL." @default.
• W1496663485 created "2016-06-24" @default.
• W1496663485 creator A5090731919 @default.
• W1496663485 date "2015-02-26" @default.
• W1496663485 modified "2023-09-28" @default.
• W1496663485 title "The Expression of MGMT and Ku80 in Primary Central Nervous System Lymphoma and Prognostic Significance" @default.
• W1496663485 cites W132112907 @default.
• W1496663485 cites W1488850773 @default.
• W1496663485 cites W1837714490 @default.
• W1496663485 cites W1840348224 @default.
• W1496663485 cites W1891612065 @default.
• W1496663485 cites W1965905617 @default.
• W1496663485 cites W1970011066 @default.
• W1496663485 cites W1971344938 @default.
• W1496663485 cites W1979281633 @default.
• W1496663485 cites W1988295204 @default.
• W1496663485 cites W1992399581 @default.
• W1496663485 cites W1998275293 @default.
• W1496663485 cites W1998988182 @default.
• W1496663485 cites W2007635472 @default.
• W1496663485 cites W2009450626 @default.
• W1496663485 cites W2010444010 @default.
• W1496663485 cites W2011231157 @default.
• W1496663485 cites W2012351614 @default.
• W1496663485 cites W2012433290 @default.
• W1496663485 cites W2013958201 @default.
• W1496663485 cites W2018983048 @default.
• W1496663485 cites W2021635906 @default.
• W1496663485 cites W2024251011 @default.
• W1496663485 cites W2025907817 @default.
• W1496663485 cites W2027681190 @default.
• W1496663485 cites W2028834400 @default.
• W1496663485 cites W2034600371 @default.
• W1496663485 cites W2039628166 @default.
• W1496663485 cites W2045751930 @default.
• W1496663485 cites W2048179868 @default.
• W1496663485 cites W2049693316 @default.
• W1496663485 cites W2052503109 @default.
• W1496663485 cites W2061407456 @default.
• W1496663485 cites W2065540956 @default.
• W1496663485 cites W2067304395 @default.
• W1496663485 cites W2070064504 @default.
• W1496663485 cites W2070079303 @default.
• W1496663485 cites W2075882488 @default.
• W1496663485 cites W2078640192 @default.
• W1496663485 cites W2082387651 @default.
• W1496663485 cites W2094059687 @default.
• W1496663485 cites W2095718447 @default.
• W1496663485 cites W2096283970 @default.
• W1496663485 cites W2096974306 @default.
• W1496663485 cites W2098548617 @default.
• W1496663485 cites W2100485814 @default.
• W1496663485 cites W2105100844 @default.
• W1496663485 cites W2112014411 @default.
• W1496663485 cites W2113924534 @default.
• W1496663485 cites W2116892842 @default.
• W1496663485 cites W2118657273 @default.
• W1496663485 cites W2119298909 @default.
• W1496663485 cites W2120319312 @default.
• W1496663485 cites W2120600645 @default.
• W1496663485 cites W2120610071 @default.
• W1496663485 cites W2129134652 @default.
• W1496663485 cites W2129682511 @default.
• W1496663485 cites W2129971649 @default.
• W1496663485 cites W2135838006 @default.
• W1496663485 cites W2137868544 @default.
• W1496663485 cites W2143665087 @default.
• W1496663485 cites W2147737558 @default.
• W1496663485 cites W2153978704 @default.
• W1496663485 cites W2155524619 @default.
• W1496663485 cites W2157338776 @default.
• W1496663485 cites W2157639946 @default.
• W1496663485 cites W2157912104 @default.
• W1496663485 cites W2158096599 @default.
• W1496663485 cites W2161179831 @default.
• W1496663485 cites W2162546222 @default.
• W1496663485 cites W2164134168 @default.
• W1496663485 cites W2167064466 @default.
• W1496663485 cites W2167288010 @default.
• W1496663485 cites W2176312424 @default.
• W1496663485 cites W2281411310 @default.
• W1496663485 cites W2317431987 @default.
• W1496663485 cites W2321522269 @default.
• W1496663485 cites W2328946792 @default.
• W1496663485 cites W296294136 @default.
• W1496663485 cites W51679543 @default.
• W1496663485 cites W951506395 @default.
• W1496663485 hasPublicationYear "2015" @default.
• W1496663485 type Work @default.
• W1496663485 sameAs 1496663485 @default.
• W1496663485 citedByCount "0" @default.
• W1496663485 crossrefType "dissertation" @default.
• W1496663485 hasAuthorship W1496663485A5090731919 @default.
• W1496663485 hasConcept C104317684 @default.
• W1496663485 hasConcept C126322002 @default.
• W1496663485 hasConcept C142724271 @default.
• W1496663485 hasConcept C143998085 @default.
• W1496663485 hasConcept C193104389 @default.

• next