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- W1496753377 abstract "Alteration in the cholinergic system is one of the major pathological hallmarks of lead (Pb) toxicity. Pb-exposure alters acetylcholinesterase (AChE) activity in brain regions which control learning and cognitive behavior. The present study is focused on the beneficial effects of calcium (Ca2+) and zinc (Zn2+) supplementation on Pbinduced alterations in AChE activity in the brains of developing and adult mice. Mice were lactationally exposed to Pb (0.2% and 1%) and supplemented with either calcium (Ca2+) or zinc (Zn2+) and the synaptosomal AChE enzyme activity was analyzed in cortex, hippocampus, cerebellum and medulla of brains excised on postnatal day (PND) 14, 21, 28 and 3 months. The histochemical staining for AChE was also performed in the sections of mice brain. Exposure to Pb resulted in a significant decrease in the activity and staining intensity of AChE. Interestingly the supplementation with Ca2+ or Zn2+ reversed the Pbinduced effects on AChE activity and expression. These findings strongly support that calcium and zinc supplementation significantly protects the brain from the Pb-induced alterations in cholinergic system." @default.
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- W1496753377 date "2010-01-01" @default.
- W1496753377 modified "2023-09-26" @default.
- W1496753377 title "Protective effects of Calcium and Zinc on Lead induced perturbations in brain acetylcholinesterase activity" @default.
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