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• W1496757932 abstract "Abstract In murine allogeneic bone marrow transplantation recipients, treatment of the hosts with a nonmyeloablative regimen, including depleting anti-CD4 and anti-CD8 mAbs, allows establishment of long-term mixed chimerism and donor-specific tolerance. However, in the xenogeneic rat-to-mouse combination, additional anti-Thy1.2 and anti-NK1.1 mAbs are required. We have now attempted to identify the xenoresistant mouse cell populations that are targeted by anti-NK1.1 and anti-Thy1.2 mAbs. C57BL/6 (B6) wild-type, B6 TCRβ−/−, and B6 TCRδ−/− mice received anti-CD4 and anti-CD8 mAbs, followed by 3 Gy of whole body irradiation, 7 Gy of thymic irradiation, and transplantation of T cell-depleted rat bone marrow cells. Anti-NK1.1 and anti-Thy1.2 mAbs were additionally administered to some groups. Increased rat chimerism was observed in TCRδ−/− mice treated with anti-CD4, anti-CD8, and anti-NK1.1 mAbs compared with similarly treated TCRβ−/− mice. In TCRβ−/− mice, but not in TCR δ−/− mice, donor chimerism was increased by treatment with anti-Thy1.2 mAb, indicating that CD4−CD8−TCRγδ+Thy1.2+NK1.1− cells (γδ T cells) are involved in the rejection of rat marrow. In addition, chimerism was enhanced in both TCRβ−/− and TCRδ−/− mice treated with anti-CD4, anti-CD8, and anti-Thy1.2 mAbs by the addition of anti-NK1.1 mAb to the conditioning regimen. Donor-specific skin graft prolongation was enhanced by anti-Thy1.2 and anti-NK1.1 mAbs in TCRδ−/− mice. Therefore, in addition to CD4 and CD8 T cells, γδ T cells and NK cells play a role in resisting engraftment of rat marrow and the induction of xenograft tolerance in mice." @default.
• W1496757932 created "2016-06-24" @default.
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• W1496757932 date "2001-01-15" @default.
• W1496757932 modified "2023-09-23" @default.
• W1496757932 title "Both γδ T Cells and NK Cells Inhibit the Engraftment of Xenogeneic Rat Bone Marrow Cells and the Induction of Xenograft Tolerance in Mice" @default.
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• W1496757932 doi "https://doi.org/10.4049/jimmunol.166.2.1398" @default.
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