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- W1496758942 abstract "Publisher Summary This chapter focuses on the step-by-step development of epithelial cancer from phenotype to genotype. Cancer research has at least two major objectives: (1) the understanding of the cancer phenotype and the way it develops and evolves as the immediate basis for the diagnosis and treatment of cancer and (2) the elucidation of the fundamental molecular-biochemical-biological modulations that underlie the development of the cancer phenotype, and its continual evolution to increasingly malignant behavior. The second objective is to add an important facet to the current concepts of basic biology, both “normal” and in disease. In many research enterprises that fall under the rubric of cancer research, both of these major objectives are important and relevant, even though the therapeutic aspects may dominate. Because epithelial cancers and their preceding and precursor epithelial changes are known only by their phenotypes, it is important to delineate these in a scientifically meaningful way. The major objective of this area of cancer research is to delineate the phenotype of the cells of each major step on the path to cancer and to change the phenotype as to prevent or even delay its evolution to carcinoma. Although the knowledge of altered genotypes may ultimately prove to be necessary for us to understand the way cancer develops, it is axiomatic that knowledge of altered phenotypes is a necessary prerequisite. There are at least three major patterns for epithelial cancer development in humans and animals. Patterns I and II are commonly seen and studied in humans. Pattern III appears to be rare, if it occurs at all, in humans." @default.
- W1496758942 created "2016-06-24" @default.
- W1496758942 creator A5002778886 @default.
- W1496758942 date "1996-01-01" @default.
- W1496758942 modified "2023-09-26" @default.
- W1496758942 title "The Step-by-Step Development of Epithelial Cancer: From Phenotype to Genotype" @default.
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