FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1496775241> ?p ?o ?g. }

• W1496775241 endingPage "8259" @default.
• W1496775241 startingPage "8252" @default.
• W1496775241 abstract "Anaerobic Tritrichomonas foetus hydrogenosomes supplemented with pyruvate and CoA effectively reduce nitrofurans and metronidazole to their respective anion free radicals. Addition of purified ferredoxins from Clostridium pasteurianum or Spinacia oleracea to these preparations causes a great stimulation of metronidazole reduction, but does not affect nitrofuran reduction. A similar stimulatory effect of ferredoxin on metronidazole reduction, but not on nitrofuran reduction, is observed in incubations containing purified NADPH:ferredoxin oxidoreductase from S. oleracea. NADH is less effective than pyruvate as a reducing cofactor for metronidazole and nitrofuran reduction by the hydrogenosomes, and these activities are not modified by the addition of ferredoxins. In contrast to the results observed with hydrogenosomes, the T. foetus soluble fraction supplemented with NADH or NADPH is able to reduce nitrofurans, but not metronidazole. Under aerobic conditions, the anion free radical metabolites generated from metronidazole and nitrofurans are oxidized, resulting in catalytic superoxide anion formation as detected by spin-trapping experiments. Oxygen consumption and H2O2 formation by T. foetus hydrogenosomes and NADPH:ferredoxin oxidoreductase are also stimulated by nitrofurans and high concentrations of metronidazole. Addition of ferredoxin enhances metronidazole-stimulated, but not nitrofuran-stimulated, oxygen consumption and H2O2 formation in both systems. These results support the role of air oxidation as a detoxification reaction of the metronidazole anion radical and the involvement of ferredoxin in its formation. On the other hand, redox cycling of nitrofurans with formation of high steady state concentrations of oxygen-derived radicals might be of toxicological significance." @default.
• W1496775241 created "2016-06-24" @default.
• W1496775241 creator A5000842323 @default.
• W1496775241 creator A5012874907 @default.
• W1496775241 creator A5032324284 @default.
• W1496775241 date "1984-07-01" @default.
• W1496775241 modified "2023-10-02" @default.
• W1496775241 title "Distinct reduction of nitrofurans and metronidazole to free radical metabolites by Tritrichomonas foetus hydrogenosomal and cytosolic enzymes." @default.
• W1496775241 cites W128823262 @default.
• W1496775241 cites W1481417992 @default.
• W1496775241 cites W1506043065 @default.
• W1496775241 cites W1523902471 @default.
• W1496775241 cites W1535367955 @default.
• W1496775241 cites W1561728426 @default.
• W1496775241 cites W1569494491 @default.
• W1496775241 cites W1580909913 @default.
• W1496775241 cites W1600668034 @default.
• W1496775241 cites W1964521603 @default.
• W1496775241 cites W1970311180 @default.
• W1496775241 cites W1970823424 @default.
• W1496775241 cites W1973399917 @default.
• W1496775241 cites W1974427354 @default.
• W1496775241 cites W1977368686 @default.
• W1496775241 cites W1989549980 @default.
• W1496775241 cites W1997310440 @default.
• W1496775241 cites W2039025886 @default.
• W1496775241 cites W2040870649 @default.
• W1496775241 cites W2042808140 @default.
• W1496775241 cites W2044842036 @default.
• W1496775241 cites W2044873877 @default.
• W1496775241 cites W2046369682 @default.
• W1496775241 cites W2047478018 @default.
• W1496775241 cites W2052714276 @default.
• W1496775241 cites W2058596283 @default.
• W1496775241 cites W2062916685 @default.
• W1496775241 cites W2064450459 @default.
• W1496775241 cites W2073821849 @default.
• W1496775241 cites W2080501796 @default.
• W1496775241 cites W2104395495 @default.
• W1496775241 cites W2140245137 @default.
• W1496775241 cites W2156963748 @default.
• W1496775241 cites W2265454289 @default.
• W1496775241 cites W2321540468 @default.
• W1496775241 cites W2329359477 @default.
• W1496775241 cites W950616869 @default.
• W1496775241 doi "https://doi.org/10.1016/s0021-9258(17)39721-1" @default.
• W1496775241 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6330106" @default.
• W1496775241 hasPublicationYear "1984" @default.
• W1496775241 type Work @default.
• W1496775241 sameAs 1496775241 @default.
• W1496775241 citedByCount "70" @default.
• W1496775241 countsByYear W14967752412012 @default.
• W1496775241 countsByYear W14967752412014 @default.
• W1496775241 countsByYear W14967752412016 @default.
• W1496775241 countsByYear W14967752412017 @default.
• W1496775241 countsByYear W14967752412019 @default.
• W1496775241 countsByYear W14967752412022 @default.
• W1496775241 crossrefType "journal-article" @default.
• W1496775241 hasAuthorship W1496775241A5000842323 @default.
• W1496775241 hasAuthorship W1496775241A5012874907 @default.
• W1496775241 hasAuthorship W1496775241A5032324284 @default.
• W1496775241 hasBestOaLocation W14967752411 @default.
• W1496775241 hasConcept C172680121 @default.
• W1496775241 hasConcept C181199279 @default.
• W1496775241 hasConcept C185592680 @default.
• W1496775241 hasConcept C2776955177 @default.
• W1496775241 hasConcept C2777396551 @default.
• W1496775241 hasConcept C2777564104 @default.
• W1496775241 hasConcept C2779234561 @default.
• W1496775241 hasConcept C501593827 @default.
• W1496775241 hasConcept C54355233 @default.
• W1496775241 hasConcept C55493867 @default.
• W1496775241 hasConcept C79115784 @default.
• W1496775241 hasConcept C86803240 @default.
• W1496775241 hasConcept C98539663 @default.
• W1496775241 hasConceptScore W1496775241C172680121 @default.
• W1496775241 hasConceptScore W1496775241C181199279 @default.
• W1496775241 hasConceptScore W1496775241C185592680 @default.
• W1496775241 hasConceptScore W1496775241C2776955177 @default.
• W1496775241 hasConceptScore W1496775241C2777396551 @default.
• W1496775241 hasConceptScore W1496775241C2777564104 @default.
• W1496775241 hasConceptScore W1496775241C2779234561 @default.
• W1496775241 hasConceptScore W1496775241C501593827 @default.
• W1496775241 hasConceptScore W1496775241C54355233 @default.
• W1496775241 hasConceptScore W1496775241C55493867 @default.
• W1496775241 hasConceptScore W1496775241C79115784 @default.
• W1496775241 hasConceptScore W1496775241C86803240 @default.
• W1496775241 hasConceptScore W1496775241C98539663 @default.
• W1496775241 hasIssue "13" @default.
• W1496775241 hasLocation W14967752411 @default.
• W1496775241 hasOpenAccess W1496775241 @default.
• W1496775241 hasPrimaryLocation W14967752411 @default.
• W1496775241 hasRelatedWork W1496775241 @default.
• W1496775241 hasRelatedWork W1563004741 @default.
• W1496775241 hasRelatedWork W1977200340 @default.
• W1496775241 hasRelatedWork W1986393148 @default.
• W1496775241 hasRelatedWork W2004293894 @default.
• W1496775241 hasRelatedWork W2004754196 @default.

• next