Matches in SemOpenAlex for { <https://semopenalex.org/work/W1496848721> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W1496848721 endingPage "43" @default.
- W1496848721 startingPage "35" @default.
- W1496848721 abstract "Ethanol induces c-Jun N-terminal kinase (JNK) activation leading to cell death in hepatocytes. However, acute alcohol exposure does not induce remarked cell death in hepatocytes. We hypothesized that active Akt may suppress JNK activation. To clarify this point, we evaluated the role of active Akt in JNK activation under treatment with hepatocyte growth factor (HGF) and compared it with ethanol treatment. Primary rat hepatocytes were treated with 10 ng/ml HGF. 10 min after that, 5 microM insulin, an activator of the Akt pathway, and/or 5 microM LY294002, an inhibitor of the pathway, were added. Hepatocytes were treated with 100 mM ethanol and LY294002. HGF treatment increased JNK activities in hepatocytes. This JNK activation was accumulated by addition of LY294002. These finding suggest that active Akt suppresses JNK activation induced by HGF. On the other hand, addition of insulin did not decrease the JNK activity, showing that insulin-induced Akt activation may rather increase JNK activity. Ethanol also induced JNK activation and this JNK activation was enhanced by LY294002 similar to HGF treatment. We found that active Akt suppressed JNK activation induced by ethanol as well as HGF in hepatocytes. JNK activation may be suppressed by prolonged active Akt or basal active Akt, rather than peaked activation of Akt induced by insulin stimulation. Our results suggest that the suppression of JNK by active Akt may prevent cell death in acute alcohol intoxication." @default.
- W1496848721 created "2016-06-24" @default.
- W1496848721 creator A5032930623 @default.
- W1496848721 creator A5053319117 @default.
- W1496848721 creator A5067021254 @default.
- W1496848721 creator A5075268361 @default.
- W1496848721 creator A5078059440 @default.
- W1496848721 date "2008-02-01" @default.
- W1496848721 modified "2023-09-23" @default.
- W1496848721 title "Ethanol-induced JNK activation suppressed via active Akt in hepatocytes." @default.
- W1496848721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18402055" @default.
- W1496848721 hasPublicationYear "2008" @default.
- W1496848721 type Work @default.
- W1496848721 sameAs 1496848721 @default.
- W1496848721 citedByCount "0" @default.
- W1496848721 crossrefType "journal-article" @default.
- W1496848721 hasAuthorship W1496848721A5032930623 @default.
- W1496848721 hasAuthorship W1496848721A5053319117 @default.
- W1496848721 hasAuthorship W1496848721A5067021254 @default.
- W1496848721 hasAuthorship W1496848721A5075268361 @default.
- W1496848721 hasAuthorship W1496848721A5078059440 @default.
- W1496848721 hasConcept C11960822 @default.
- W1496848721 hasConcept C170493617 @default.
- W1496848721 hasConcept C185592680 @default.
- W1496848721 hasConcept C2776912716 @default.
- W1496848721 hasConcept C2776996007 @default.
- W1496848721 hasConcept C502942594 @default.
- W1496848721 hasConcept C55493867 @default.
- W1496848721 hasConcept C62478195 @default.
- W1496848721 hasConcept C75217442 @default.
- W1496848721 hasConcept C86554907 @default.
- W1496848721 hasConcept C86803240 @default.
- W1496848721 hasConcept C88045685 @default.
- W1496848721 hasConcept C95444343 @default.
- W1496848721 hasConceptScore W1496848721C11960822 @default.
- W1496848721 hasConceptScore W1496848721C170493617 @default.
- W1496848721 hasConceptScore W1496848721C185592680 @default.
- W1496848721 hasConceptScore W1496848721C2776912716 @default.
- W1496848721 hasConceptScore W1496848721C2776996007 @default.
- W1496848721 hasConceptScore W1496848721C502942594 @default.
- W1496848721 hasConceptScore W1496848721C55493867 @default.
- W1496848721 hasConceptScore W1496848721C62478195 @default.
- W1496848721 hasConceptScore W1496848721C75217442 @default.
- W1496848721 hasConceptScore W1496848721C86554907 @default.
- W1496848721 hasConceptScore W1496848721C86803240 @default.
- W1496848721 hasConceptScore W1496848721C88045685 @default.
- W1496848721 hasConceptScore W1496848721C95444343 @default.
- W1496848721 hasIssue "1" @default.
- W1496848721 hasLocation W14968487211 @default.
- W1496848721 hasOpenAccess W1496848721 @default.
- W1496848721 hasPrimaryLocation W14968487211 @default.
- W1496848721 hasRelatedWork W1539607691 @default.
- W1496848721 hasRelatedWork W1678392871 @default.
- W1496848721 hasRelatedWork W1963964724 @default.
- W1496848721 hasRelatedWork W2001189938 @default.
- W1496848721 hasRelatedWork W2002240376 @default.
- W1496848721 hasRelatedWork W2011533623 @default.
- W1496848721 hasRelatedWork W2037264667 @default.
- W1496848721 hasRelatedWork W2038484424 @default.
- W1496848721 hasRelatedWork W2044709113 @default.
- W1496848721 hasRelatedWork W2068862545 @default.
- W1496848721 hasRelatedWork W2076087086 @default.
- W1496848721 hasRelatedWork W2097120271 @default.
- W1496848721 hasRelatedWork W2148205807 @default.
- W1496848721 hasRelatedWork W2158979404 @default.
- W1496848721 hasRelatedWork W2188666218 @default.
- W1496848721 hasRelatedWork W2427624666 @default.
- W1496848721 hasRelatedWork W2606865341 @default.
- W1496848721 hasRelatedWork W2908934472 @default.
- W1496848721 hasRelatedWork W2921481588 @default.
- W1496848721 hasRelatedWork W3151775693 @default.
- W1496848721 hasVolume "43" @default.
- W1496848721 isParatext "false" @default.
- W1496848721 isRetracted "false" @default.
- W1496848721 magId "1496848721" @default.
- W1496848721 workType "article" @default.