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- W1496921962 abstract "Abstract Immunotherapy of cancer has emerged as a promising new strategy to complement standard anticancer therapies such as chemotherapy, surgery, and radiotherapy. While the currently available data from clinical trials of cancer vaccines provide evidence for the therapeutic benefit of this approach, it is currently confined to a minority of patients. In this chapter, we give an overview on current concepts and experimental models of cancer immunotherapy with a particular focus on cancer cell‐ and dendritic cell–based vaccines. We then proceed to discuss the emerging new data on immune evasion strategies of cancer such as the secretion of paracrine immunoinhibitory factors and the role of regulatory T cells. Exploration of immune escape mechanisms are critical for identification of novel immunotherapy targets to allow for further optimization of cancer immunotherapy. Such strategies hold considerable promise when incorporated into multimodal approaches as exemplified by the combination of chemotherapeutic cytoreduction with tumour vaccination or adoptive transfer of immune effector cells as described in the final part of this chapter. The rapid preclinical evaluation of these novel approaches is today greatly facilitated by the widespread availability of “fully humanized” mouse xenograft models. In addition, good manufacturing practice (GMP)‐grade reagents for immune cell purification support a swift transfer of new experimental insights from bench to bedside. Also targeting patients with low tumour burden instead of bulky or metastasized disease will further the success of clinical immunotherapy." @default.
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- W1496921962 date "2007-10-15" @default.
- W1496921962 modified "2023-10-10" @default.
- W1496921962 title "Models for Immunotherapy and Cancer Vaccines" @default.
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- W1496921962 doi "https://doi.org/10.1002/9780470025079.chap68.pub2" @default.
- W1496921962 hasPublicationYear "2007" @default.
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