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- W1497019071 abstract "Background: Previous studies on sarcoidosishave shown that the addition of an anti-fungalmedication to the traditional treatment withcorticosteroids improves treatment efficiency.It cannot be excluded that the effect is due to astimulatory effect of the anti-fungal medicationon the action of corticosteroids. To assess thispossibility a study was undertaken where patientswith sarcoidosis stage 2 were given an antifungalmedication only.Material and methods: Study subjects (n=10)were recruited from newly diagnosed cases ofsarcoidosis and observed for 3 months to reducethe risk of including patients with spontaneousregression of the disease. They were given an anti-fungal medication for 2–11 months and x-rayswere taken before and every second month afterstarting the treatment. Diffusion capacity, serumangiotensin converting enzyme, and chitotriosidasewere determined as markers of sarcoidosisactivity.Results: There were improvements in the x-rayfindings as well as the markers of sarcoidosis in 8out of 10 patients. Two patients had an exacerbationof their disease after two months and theywere given corticosteroids in addition to theanti-fungal medication.Comments: The results demonstrate that thebeneficial effects of anti-fungal medication arespecific and not caused by an improvement ofcorticosteroid efficacy. The findings provide abasis for larger clinical studies." @default.
- W1497019071 created "2016-06-24" @default.
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- W1497019071 date "2010-12-01" @default.
- W1497019071 modified "2023-10-16" @default.
- W1497019071 title "Antimikotiki in sarkoidoza" @default.
- W1497019071 cites W113520702 @default.
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- W1497019071 hasPublicationYear "2010" @default.
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