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• W1497103537 abstract "CD117-positive cells contributing to the cardiac cell turnover in the normal and pathological conditions have been recently described in the adult human heart. Since the precise spatial and temporal expression of extracellular matrix proteins and their receptors is critical for proper organ formation, we have analyzed and compared the spatial distribution of cardiac primitive CD117-positive cells in the human adult normal and pathological hearts with chronic ischemic cardiomyopathy, with respect to the localization and expression of laminin and integrin isoforms. In the pathological hearts, CD117-positive cells, visualized by immunofluorescence, were significantly more numerous than in the normal hearts. These cells were localized mainly in the atria and were up to 38-fold more numerous in the subepicardium than in the myocardium. Compared with normal hearts, most CD117-positive cells in the subepicardium of pathological hearts were α6 integrin-positive. Laminin-1, typical of developing heart, was found predominantly in the subepicardium of normal and pathological adult hearts. Western blotting revealed its highest expression in the normal atrium and pathological left ventricle. The presence of laminin-1 in vitro, in contrast to laminin-2, increased proliferation and reduced apoptosis of CD117-positive cells, with the latter effect being related to integrin α6 expression. In vitro, the epithelialmesenchymal transition of epicardial cells from human adult heart, cultured" @default.
• W1497103537 created "2016-06-24" @default.
• W1497103537 creator A5089804124 @default.
• W1497103537 date "2008-01-01" @default.
• W1497103537 modified "2023-09-23" @default.
• W1497103537 title "Cd 117-positive cardiac primitive cells: their localization and interaction with extracellular matrix in the human adult normal and pathological heart" @default.
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• W1497103537 doi "https://doi.org/10.6092/unina/fedoa/1834" @default.
• W1497103537 hasPublicationYear "2008" @default.
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