Matches in SemOpenAlex for { <https://semopenalex.org/work/W149710922> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W149710922 abstract "Dimethoate (DM) is biotransformed to an anti-cholinesterase oxoanalogue via liver cytochrome P-450 system. The present investigation deals with a semi-quantitative method for estimating this oxidative desulfuration: DM incubation with liver microsomes and co-factors at optimized concentrations and conditions yields oxo-DM. This is quantitatively expressed by the inhibition of serum cholinesterase activity (ChEA). Concentration and time effects on the reaction rates were studied in vitro. The calculated kinetic parameters pointed to a high affinity of P-450 for DM. The relationship between various substrates of the P-450 system were studied as well. Concentrations of 0.1 to 10 mM DM led to a linear decrease of the rates of N-demethylation and p-hydroxylation. Similar effects were observed in microsomes from rats treated with DM in vivo where a higher capacity for DM biotransformation was found. This capacity increases with a high initial rate after the treatment inspite of the decreasing P-450 quantity as measured by CO-binding spectra. On the third hour after a single dose of 1.5 mg/kg DM desulfuration activity reached 140% as compared with control values (p<0.01), while aniline hydroxylation, aminopyrine N-demethylation and P-450 were 78%, 76%, and 67%, respectively, (p<0.01). Microsomal protein remained practically unchanged." @default.
- W149710922 created "2016-06-24" @default.
- W149710922 creator A5011906178 @default.
- W149710922 creator A5023174086 @default.
- W149710922 creator A5041300262 @default.
- W149710922 creator A5041392370 @default.
- W149710922 date "1986-01-01" @default.
- W149710922 modified "2023-09-26" @default.
- W149710922 title "Experimental Studies on Dimethoate Oxidative Desulfuration" @default.
- W149710922 doi "https://doi.org/10.1007/978-3-642-71248-7_59" @default.
- W149710922 hasPublicationYear "1986" @default.
- W149710922 type Work @default.
- W149710922 sameAs 149710922 @default.
- W149710922 citedByCount "0" @default.
- W149710922 crossrefType "book-chapter" @default.
- W149710922 hasAuthorship W149710922A5011906178 @default.
- W149710922 hasAuthorship W149710922A5023174086 @default.
- W149710922 hasAuthorship W149710922A5041300262 @default.
- W149710922 hasAuthorship W149710922A5041392370 @default.
- W149710922 hasConcept C104317684 @default.
- W149710922 hasConcept C150194340 @default.
- W149710922 hasConcept C150903083 @default.
- W149710922 hasConcept C178790620 @default.
- W149710922 hasConcept C181199279 @default.
- W149710922 hasConcept C185592680 @default.
- W149710922 hasConcept C190727270 @default.
- W149710922 hasConcept C202199734 @default.
- W149710922 hasConcept C207001950 @default.
- W149710922 hasConcept C25642318 @default.
- W149710922 hasConcept C2779244968 @default.
- W149710922 hasConcept C2780768313 @default.
- W149710922 hasConcept C2781109383 @default.
- W149710922 hasConcept C27881333 @default.
- W149710922 hasConcept C43617362 @default.
- W149710922 hasConcept C526171541 @default.
- W149710922 hasConcept C55493867 @default.
- W149710922 hasConcept C57600042 @default.
- W149710922 hasConcept C86803240 @default.
- W149710922 hasConcept C87644729 @default.
- W149710922 hasConceptScore W149710922C104317684 @default.
- W149710922 hasConceptScore W149710922C150194340 @default.
- W149710922 hasConceptScore W149710922C150903083 @default.
- W149710922 hasConceptScore W149710922C178790620 @default.
- W149710922 hasConceptScore W149710922C181199279 @default.
- W149710922 hasConceptScore W149710922C185592680 @default.
- W149710922 hasConceptScore W149710922C190727270 @default.
- W149710922 hasConceptScore W149710922C202199734 @default.
- W149710922 hasConceptScore W149710922C207001950 @default.
- W149710922 hasConceptScore W149710922C25642318 @default.
- W149710922 hasConceptScore W149710922C2779244968 @default.
- W149710922 hasConceptScore W149710922C2780768313 @default.
- W149710922 hasConceptScore W149710922C2781109383 @default.
- W149710922 hasConceptScore W149710922C27881333 @default.
- W149710922 hasConceptScore W149710922C43617362 @default.
- W149710922 hasConceptScore W149710922C526171541 @default.
- W149710922 hasConceptScore W149710922C55493867 @default.
- W149710922 hasConceptScore W149710922C57600042 @default.
- W149710922 hasConceptScore W149710922C86803240 @default.
- W149710922 hasConceptScore W149710922C87644729 @default.
- W149710922 hasLocation W1497109221 @default.
- W149710922 hasOpenAccess W149710922 @default.
- W149710922 hasPrimaryLocation W1497109221 @default.
- W149710922 hasRelatedWork W1959756100 @default.
- W149710922 hasRelatedWork W1999095890 @default.
- W149710922 hasRelatedWork W2013834373 @default.
- W149710922 hasRelatedWork W2029332281 @default.
- W149710922 hasRelatedWork W2049982823 @default.
- W149710922 hasRelatedWork W2052736223 @default.
- W149710922 hasRelatedWork W2062291841 @default.
- W149710922 hasRelatedWork W2065848961 @default.
- W149710922 hasRelatedWork W2066616493 @default.
- W149710922 hasRelatedWork W2069286401 @default.
- W149710922 hasRelatedWork W2070384173 @default.
- W149710922 hasRelatedWork W2093624471 @default.
- W149710922 hasRelatedWork W2169705290 @default.
- W149710922 hasRelatedWork W2225011999 @default.
- W149710922 hasRelatedWork W2273512116 @default.
- W149710922 hasRelatedWork W2409123211 @default.
- W149710922 hasRelatedWork W2409824396 @default.
- W149710922 hasRelatedWork W2412920428 @default.
- W149710922 hasRelatedWork W2413100974 @default.
- W149710922 hasRelatedWork W2462031591 @default.
- W149710922 isParatext "false" @default.
- W149710922 isRetracted "false" @default.
- W149710922 magId "149710922" @default.
- W149710922 workType "book-chapter" @default.