FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1497113035> ?p ?o ?g. }

• W1497113035 endingPage "5127" @default.
• W1497113035 startingPage "5122" @default.
• W1497113035 abstract "The preponderance of nonpolar contacts between CoA and chloramphenicol acetyltransferase in the high resolution structure of the binary complex prompted a study of selected hydrophobic residues by site-directed mutagenesis and steady-state kinetic analysis. Substitutions of three aromatic residues were used to evaluate binding contacts with the adenine moiety of CoA (Tyr-178), the pantetheine arm of the coenzyme (Tyr-56), and the S-acyl substituent (Phe-33). For those substitutions at residues 56 and 178 that cannot promote alternative polar interactions there is a correlation between residue hydrophobicity and the free energy of formation of the binary and ternary complexes of acetyl-CoA and chloramphenicol acetyltransferase and of the transition-state complex. Substitutions at Tyr-178 destabilize all such complexes to approximately the same extent (uniform binding changes), whereas those at Tyr-56 and Phe-33 cause differential binding changes, having a greater effect on the transition state than on either of the other complexes with acetyl-CoA." @default.
• W1497113035 created "2016-06-24" @default.
• W1497113035 creator A5035939194 @default.
• W1497113035 creator A5054081363 @default.
• W1497113035 date "1992-03-01" @default.
• W1497113035 modified "2023-09-27" @default.
• W1497113035 title "Acetyl coenzyme A binding by chloramphenicol acetyltransferase. Hydrophobic determinants of recognition and catalysis." @default.
• W1497113035 cites W104374906 @default.
• W1497113035 cites W1604452613 @default.
• W1497113035 cites W1755176278 @default.
• W1497113035 cites W1775749144 @default.
• W1497113035 cites W1972419349 @default.
• W1497113035 cites W1979212500 @default.
• W1497113035 cites W2018914206 @default.
• W1497113035 cites W2022008972 @default.
• W1497113035 cites W2022156980 @default.
• W1497113035 cites W2032106645 @default.
• W1497113035 cites W2033891782 @default.
• W1497113035 cites W2036874513 @default.
• W1497113035 cites W2043855562 @default.
• W1497113035 cites W2058968386 @default.
• W1497113035 cites W2061520567 @default.
• W1497113035 cites W2071372873 @default.
• W1497113035 cites W2079901091 @default.
• W1497113035 cites W2083719717 @default.
• W1497113035 cites W2092002806 @default.
• W1497113035 cites W2094186244 @default.
• W1497113035 cites W2100837269 @default.
• W1497113035 cites W2104021409 @default.
• W1497113035 cites W2320934986 @default.
• W1497113035 cites W2888511473 @default.
• W1497113035 cites W4242700819 @default.
• W1497113035 doi "https://doi.org/10.1016/s0021-9258(18)42739-1" @default.
• W1497113035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1544895" @default.
• W1497113035 hasPublicationYear "1992" @default.
• W1497113035 type Work @default.
• W1497113035 sameAs 1497113035 @default.
• W1497113035 citedByCount "20" @default.
• W1497113035 countsByYear W14971130352012 @default.
• W1497113035 countsByYear W14971130352013 @default.
• W1497113035 countsByYear W14971130352015 @default.
• W1497113035 countsByYear W14971130352016 @default.
• W1497113035 countsByYear W14971130352020 @default.
• W1497113035 countsByYear W14971130352021 @default.
• W1497113035 countsByYear W14971130352022 @default.
• W1497113035 countsByYear W14971130352023 @default.
• W1497113035 crossrefType "journal-article" @default.
• W1497113035 hasAuthorship W1497113035A5035939194 @default.
• W1497113035 hasAuthorship W1497113035A5054081363 @default.
• W1497113035 hasBestOaLocation W14971130351 @default.
• W1497113035 hasConcept C101762097 @default.
• W1497113035 hasConcept C104317684 @default.
• W1497113035 hasConcept C119157956 @default.
• W1497113035 hasConcept C134651460 @default.
• W1497113035 hasConcept C150194340 @default.
• W1497113035 hasConcept C161790260 @default.
• W1497113035 hasConcept C181199279 @default.
• W1497113035 hasConcept C185592680 @default.
• W1497113035 hasConcept C197957613 @default.
• W1497113035 hasConcept C2778473333 @default.
• W1497113035 hasConcept C2779123261 @default.
• W1497113035 hasConcept C2779649592 @default.
• W1497113035 hasConcept C2780730277 @default.
• W1497113035 hasConcept C501593827 @default.
• W1497113035 hasConcept C55493867 @default.
• W1497113035 hasConceptScore W1497113035C101762097 @default.
• W1497113035 hasConceptScore W1497113035C104317684 @default.
• W1497113035 hasConceptScore W1497113035C119157956 @default.
• W1497113035 hasConceptScore W1497113035C134651460 @default.
• W1497113035 hasConceptScore W1497113035C150194340 @default.
• W1497113035 hasConceptScore W1497113035C161790260 @default.
• W1497113035 hasConceptScore W1497113035C181199279 @default.
• W1497113035 hasConceptScore W1497113035C185592680 @default.
• W1497113035 hasConceptScore W1497113035C197957613 @default.
• W1497113035 hasConceptScore W1497113035C2778473333 @default.
• W1497113035 hasConceptScore W1497113035C2779123261 @default.
• W1497113035 hasConceptScore W1497113035C2779649592 @default.
• W1497113035 hasConceptScore W1497113035C2780730277 @default.
• W1497113035 hasConceptScore W1497113035C501593827 @default.
• W1497113035 hasConceptScore W1497113035C55493867 @default.
• W1497113035 hasIssue "8" @default.
• W1497113035 hasLocation W14971130351 @default.
• W1497113035 hasOpenAccess W1497113035 @default.
• W1497113035 hasPrimaryLocation W14971130351 @default.
• W1497113035 hasRelatedWork W1495901646 @default.
• W1497113035 hasRelatedWork W1974034312 @default.
• W1497113035 hasRelatedWork W2015582066 @default.
• W1497113035 hasRelatedWork W2045713354 @default.
• W1497113035 hasRelatedWork W2058340182 @default.
• W1497113035 hasRelatedWork W2076801272 @default.
• W1497113035 hasRelatedWork W2083592549 @default.
• W1497113035 hasRelatedWork W2111059729 @default.
• W1497113035 hasRelatedWork W2121086659 @default.
• W1497113035 hasRelatedWork W2163034160 @default.
• W1497113035 hasVolume "267" @default.
• W1497113035 isParatext "false" @default.
• W1497113035 isRetracted "false" @default.
• W1497113035 magId "1497113035" @default.

• next