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• W1497147114 abstract "L-myo-Inositol 1-phosphate synthase (MIPS, EC 5.5.1.4), the key enzyme in the inositol and phosphoinositide biosynthetic pathway, is present throughout evolutionarily diverse organisms and is considered an ancient protein/gene. Analysis by multiple sequence alignment, phylogenetic tree generation and comparison of newly determined crystal structures provides new insight into the origin and evolutionary relationships among the various MIPS proteins/genes. The evolution of the MIPS protein/gene among the prokaryotes seems more diverse and complex than amongst the eukaryotes. However, conservation of a 'core catalytic structure' among the MIPS proteins implies an essential function of the enzyme in cellular metabolism throughout the biological kingdom." @default.
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• W1497147114 date "2003-09-11" @default.
• W1497147114 modified "2023-10-14" @default.
• W1497147114 title "Diversification and evolution of<scp>L</scp>-<i>myo</i>-inositol 1-phosphate synthase¹" @default.
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• W1497147114 doi "https://doi.org/10.1016/s0014-5793(03)00974-8" @default.
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