FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1497151185> ?p ?o ?g. }

• W1497151185 endingPage "2193" @default.
• W1497151185 startingPage "2185" @default.
• W1497151185 abstract "Abstract Because the effects of red blood cell (RBC) concentration on hemostasis and thrombus formation have not been studied experimentally under conditions of whole blood flow without anti-coagulation, normal baboons were bled or transfused to obtain three different groups: a low hematocrit (Ht) group (20% less than Ht less than 25%), a normal Ht group (35% less than Ht less than 40%), and a high Ht group (50% less than Ht less than 55%). Measurements of platelet count, bleeding time, platelet aggregation, fibrinogen level, and coagulation time (APTT) were equivalent to normal values in each group. Thrombus formation was induced using a device composed of collagen-coated tubing followed by two sequentially placed expansion chambers designed to exhibit flow recirculation and stasis. The device was exposed for up to 40 minutes in an arterio-venous shunt system. Wall shear rates in the tubular collagen segment were 100 seconds-1 and 500 to 750 seconds-1. The accumulation of 111In-platelets and 125I-fibrinogen/fibrin was measured radioisotopically; RBC incorporation was determined from measurements of total thrombus hemoglobin. Thrombus that formed on the collagen substrate was rich in platelets and poor in fibrin and RBCs. Under high flow conditions, thrombus composition showed no dependence on Ht. Surprisingly, under low flow conditions, platelet thrombus volume was negatively correlated with Ht (r = -.73, P = .005), and was increased by greater than twofold in the low Ht group as compared with the high Ht group. Thrombus that formed in the disturbed flow regions contained relatively few platelets but was rich in fibrin and RBCs. The predominant finding was a positive correlation between RBC incorporation and Ht at both high and low shear rates (r = .90, P = .00003; and r = .77, P = .002, respectively), with thrombus volume increasing three- to sixfold between the low and high Ht groups. Thus, in vivo variations in Ht ranging between 20% and 55% did not affect hemostasis, but were found either to promote or inhibit the net accumulation of thrombus, depending on local flow conditions." @default.
• W1497151185 created "2016-06-24" @default.
• W1497151185 creator A5007663061 @default.
• W1497151185 creator A5027011914 @default.
• W1497151185 date "1990-06-01" @default.
• W1497151185 modified "2023-10-14" @default.
• W1497151185 title "Effects of red blood cell concentration on hemostasis and thrombus formation in a primate model" @default.
• W1497151185 cites W1497264889 @default.
• W1497151185 cites W1653228448 @default.
• W1497151185 cites W1967734296 @default.
• W1497151185 cites W1971386061 @default.
• W1497151185 cites W1972225863 @default.
• W1497151185 cites W1975134701 @default.
• W1497151185 cites W1982172668 @default.
• W1497151185 cites W1982346511 @default.
• W1497151185 cites W2001416099 @default.
• W1497151185 cites W2001544152 @default.
• W1497151185 cites W2004356344 @default.
• W1497151185 cites W2027199532 @default.
• W1497151185 cites W2029663570 @default.
• W1497151185 cites W2029730388 @default.
• W1497151185 cites W2051325547 @default.
• W1497151185 cites W2052878423 @default.
• W1497151185 cites W2061607137 @default.
• W1497151185 cites W2084127915 @default.
• W1497151185 cites W2093366950 @default.
• W1497151185 cites W2147180004 @default.
• W1497151185 cites W2154671735 @default.
• W1497151185 cites W2338072936 @default.
• W1497151185 cites W2407900120 @default.
• W1497151185 cites W2414783014 @default.
• W1497151185 cites W2418553951 @default.
• W1497151185 cites W2418890452 @default.
• W1497151185 cites W2443255991 @default.
• W1497151185 cites W2530268384 @default.
• W1497151185 cites W2598110022 @default.
• W1497151185 cites W321836716 @default.
• W1497151185 cites W72055241 @default.
• W1497151185 cites W980563216 @default.
• W1497151185 doi "https://doi.org/10.1182/blood.v75.11.2185.2185" @default.
• W1497151185 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2346782" @default.
• W1497151185 hasPublicationYear "1990" @default.
• W1497151185 type Work @default.
• W1497151185 sameAs 1497151185 @default.
• W1497151185 citedByCount "61" @default.
• W1497151185 countsByYear W14971511852012 @default.
• W1497151185 countsByYear W14971511852013 @default.
• W1497151185 countsByYear W14971511852014 @default.
• W1497151185 countsByYear W14971511852015 @default.
• W1497151185 countsByYear W14971511852016 @default.
• W1497151185 countsByYear W14971511852017 @default.
• W1497151185 countsByYear W14971511852018 @default.
• W1497151185 countsByYear W14971511852019 @default.
• W1497151185 countsByYear W14971511852021 @default.
• W1497151185 countsByYear W14971511852022 @default.
• W1497151185 crossrefType "journal-article" @default.
• W1497151185 hasAuthorship W1497151185A5007663061 @default.
• W1497151185 hasAuthorship W1497151185A5027011914 @default.
• W1497151185 hasBestOaLocation W14971511851 @default.
• W1497151185 hasConcept C126322002 @default.
• W1497151185 hasConcept C185592680 @default.
• W1497151185 hasConcept C203014093 @default.
• W1497151185 hasConcept C2778382381 @default.
• W1497151185 hasConcept C2778589496 @default.
• W1497151185 hasConcept C2779036427 @default.
• W1497151185 hasConcept C2780959883 @default.
• W1497151185 hasConcept C2781362458 @default.
• W1497151185 hasConcept C54173615 @default.
• W1497151185 hasConcept C55493867 @default.
• W1497151185 hasConcept C71924100 @default.
• W1497151185 hasConcept C89560881 @default.
• W1497151185 hasConceptScore W1497151185C126322002 @default.
• W1497151185 hasConceptScore W1497151185C185592680 @default.
• W1497151185 hasConceptScore W1497151185C203014093 @default.
• W1497151185 hasConceptScore W1497151185C2778382381 @default.
• W1497151185 hasConceptScore W1497151185C2778589496 @default.
• W1497151185 hasConceptScore W1497151185C2779036427 @default.
• W1497151185 hasConceptScore W1497151185C2780959883 @default.
• W1497151185 hasConceptScore W1497151185C2781362458 @default.
• W1497151185 hasConceptScore W1497151185C54173615 @default.
• W1497151185 hasConceptScore W1497151185C55493867 @default.
• W1497151185 hasConceptScore W1497151185C71924100 @default.
• W1497151185 hasConceptScore W1497151185C89560881 @default.
• W1497151185 hasIssue "11" @default.
• W1497151185 hasLocation W14971511851 @default.
• W1497151185 hasOpenAccess W1497151185 @default.
• W1497151185 hasPrimaryLocation W14971511851 @default.
• W1497151185 hasRelatedWork W2116031492 @default.
• W1497151185 hasRelatedWork W2142809579 @default.
• W1497151185 hasRelatedWork W2410532786 @default.
• W1497151185 hasRelatedWork W2412885513 @default.
• W1497151185 hasRelatedWork W2944221021 @default.
• W1497151185 hasRelatedWork W3043351014 @default.
• W1497151185 hasRelatedWork W32199646 @default.
• W1497151185 hasRelatedWork W4290362379 @default.
• W1497151185 hasRelatedWork W4323826591 @default.
• W1497151185 hasRelatedWork W96873760 @default.
• W1497151185 hasVolume "75" @default.

• next