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- W149716295 abstract "Purine nucleotides and nucleosides were shown in 1929 to have potent effects on the heart and vasculature, in the first indication that these agents can act as extracellular signalling molecules in the cardiovascular system ( and ). The seminal discovery by and that many vasodilators require the presence of an intact endothelium to mediate vascular relaxation paved the way for the identification and characterisation of receptors for purines and pyrimidines on the endothelium. In common with a number of other endogenous vasodilators, ADP and ATP were shown to act at receptors on endothelial cells to mediate vasodilatation via the release of an endothelium-derived relaxing factor (EDRF) ( and ), subsequently identified as nitric oxide (NO) (; ). Purine (ADP and ATP) and pyrimidine (UDP and UTP) nucleotides can also elicit the release of prostacyclin () and endothelium-derived hyperpolarising factor (EDHF) () from endothelial cells. The vasodilator response to adenosine has also been shown to be mediated, at least in part, via receptors on the endothelium in some blood vessels." @default.
- W149716295 created "2016-06-24" @default.
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- W149716295 date "2001-01-01" @default.
- W149716295 modified "2023-10-11" @default.
- W149716295 title "Roles of Purines and Pyrimidines in Endothelium" @default.
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- W149716295 doi "https://doi.org/10.1007/978-3-642-56921-0_4" @default.
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