FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1497172961> ?p ?o ?g. }

• W1497172961 endingPage "199" @default.
• W1497172961 startingPage "189" @default.
• W1497172961 abstract "Abstract. Kacerovsky M, Brehm A, Chmelik M, Schmid AI, Szendroedi J, Kacerovsky-Bielesz G, Nowotny P, Lettner A, Wolzt M, Jones JG, Roden M (Karl-Landsteiner Institute for Endocrinology and Metabolism, Vienna; 1st Medical Department, Hanusch Hospital, Vienna; MR Center of Excellence, Medical University of Vienna, Vienna, Austria; Institute for Clinical Diabetology, German Diabetes Center (Leibniz Center for Diabetes Research), Düsseldorf; Heinrich-Heine University Düsseldorf, Düsseldorf, Germany; Medical University of Vienna, Vienna, Austria; and University of Coimbra, Coimbra, Portugal). Impaired insulin stimulation of muscular ATP production in patients with type 1 diabetes. J Intern Med 2011; 269: 189–199. Objective. In type 2 diabetic patients and their first-degree relatives, insulin resistance (IR) is associated with impairment of insulin-stimulated myocellular glucose-6-phosphate (g6p) and unidirectional flux through ATP synthase (fATP), suggesting the presence of inherited abnormal mitochondrial oxidative fitness. We hypothesized that patients with long-standing type 1 diabetes may also exhibit insulin resistance as well as lower fATP. Design. This single-centre trial was registered at ClinicalTrials.gov (NCT00481598). Subjects. We included eight nonobese type 1 diabetic patients (mean diabetes duration: 17 years) with near-target glycaemic control [haemoglobin A1c (HbA1c): 6.8 ± 0.4%] during treatment with continuous subcutaneous insulin infusion pumps and eight healthy volunteers (HbA1c: 5.4 ± 0.2%) of comparable age, body mass and level of physical activity. Outcome measures. Myocellular fATP, g6p and intramyocellular lipid content (IMCL) were measured with 1H/31P magnetic resonance spectroscopy during fasting and hyperinsulinaemic–euglycaemic clamp tests. Results. Fasting fATP, g6p and IMCL did not differ between groups. During stimulation by insulin, type 1 diabetic patients exhibited ∼50% (P < 0.001) lower whole-body glucose disposal along with ∼42% (P = 0.003) lower intramyocellular g6p and ∼25% (P = 0.024) lower fATP. Insulin-stimulated fATP correlated positively with whole-body insulin sensitivity (R = 0.706, P = 0.002) and negatively with HbA1c (R = −0.675, P = 0.004). Conclusions. Despite documented near-target glycaemic control for 1 year, nonobese patients with long-standing type 1 diabetes can exhibit insulin resistance. This associates with lower insulin-stimulated flux through muscular ATP synthase which could result from glucose toxicity." @default.
• W1497172961 created "2016-06-24" @default.
• W1497172961 creator A5012112219 @default.
• W1497172961 creator A5018517341 @default.
• W1497172961 creator A5022032933 @default.
• W1497172961 creator A5027328122 @default.
• W1497172961 creator A5035551047 @default.
• W1497172961 creator A5048083486 @default.
• W1497172961 creator A5049615554 @default.
• W1497172961 creator A5053538919 @default.
• W1497172961 creator A5054404247 @default.
• W1497172961 creator A5056480184 @default.
• W1497172961 creator A5060108017 @default.
• W1497172961 date "2011-01-11" @default.
• W1497172961 modified "2023-10-16" @default.
• W1497172961 title "Impaired insulin stimulation of muscular ATP production in patients with type 1 diabetes" @default.
• W1497172961 cites W1752045965 @default.
• W1497172961 cites W1964403842 @default.
• W1497172961 cites W1966078541 @default.
• W1497172961 cites W1968760557 @default.
• W1497172961 cites W1969753458 @default.
• W1497172961 cites W1973842058 @default.
• W1497172961 cites W1978287190 @default.
• W1497172961 cites W1985142779 @default.
• W1497172961 cites W1990014214 @default.
• W1497172961 cites W1998158504 @default.
• W1497172961 cites W2011205813 @default.
• W1497172961 cites W2016253969 @default.
• W1497172961 cites W2022816741 @default.
• W1497172961 cites W2027670788 @default.
• W1497172961 cites W2032327865 @default.
• W1497172961 cites W2035087378 @default.
• W1497172961 cites W2036577693 @default.
• W1497172961 cites W2040456345 @default.
• W1497172961 cites W2042042400 @default.
• W1497172961 cites W2062229924 @default.
• W1497172961 cites W2066736958 @default.
• W1497172961 cites W2071572735 @default.
• W1497172961 cites W2075171810 @default.
• W1497172961 cites W2077289504 @default.
• W1497172961 cites W2079390800 @default.
• W1497172961 cites W2083741754 @default.
• W1497172961 cites W2096629763 @default.
• W1497172961 cites W2097146819 @default.
• W1497172961 cites W2097286914 @default.
• W1497172961 cites W2098262221 @default.
• W1497172961 cites W2104502652 @default.
• W1497172961 cites W2112238233 @default.
• W1497172961 cites W2121536172 @default.
• W1497172961 cites W2122202225 @default.
• W1497172961 cites W2123212032 @default.
• W1497172961 cites W2126612613 @default.
• W1497172961 cites W2134996831 @default.
• W1497172961 cites W2139467028 @default.
• W1497172961 cites W2148020672 @default.
• W1497172961 cites W2153462741 @default.
• W1497172961 cites W2155278711 @default.
• W1497172961 cites W2156223798 @default.
• W1497172961 cites W2164818281 @default.
• W1497172961 cites W2195036252 @default.
• W1497172961 cites W4230801048 @default.
• W1497172961 cites W4245301856 @default.
• W1497172961 cites W4248786683 @default.
• W1497172961 cites W4249843815 @default.
• W1497172961 cites W4250266674 @default.
• W1497172961 cites W4255388631 @default.
• W1497172961 doi "https://doi.org/10.1111/j.1365-2796.2010.02298.x" @default.
• W1497172961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21205021" @default.
• W1497172961 hasPublicationYear "2011" @default.
• W1497172961 type Work @default.
• W1497172961 sameAs 1497172961 @default.
• W1497172961 citedByCount "40" @default.
• W1497172961 countsByYear W14971729612012 @default.
• W1497172961 countsByYear W14971729612013 @default.
• W1497172961 countsByYear W14971729612014 @default.
• W1497172961 countsByYear W14971729612015 @default.
• W1497172961 countsByYear W14971729612016 @default.
• W1497172961 countsByYear W14971729612018 @default.
• W1497172961 countsByYear W14971729612019 @default.
• W1497172961 countsByYear W14971729612020 @default.
• W1497172961 countsByYear W14971729612021 @default.
• W1497172961 countsByYear W14971729612023 @default.
• W1497172961 crossrefType "journal-article" @default.
• W1497172961 hasAuthorship W1497172961A5012112219 @default.
• W1497172961 hasAuthorship W1497172961A5018517341 @default.
• W1497172961 hasAuthorship W1497172961A5022032933 @default.
• W1497172961 hasAuthorship W1497172961A5027328122 @default.
• W1497172961 hasAuthorship W1497172961A5035551047 @default.
• W1497172961 hasAuthorship W1497172961A5048083486 @default.
• W1497172961 hasAuthorship W1497172961A5049615554 @default.
• W1497172961 hasAuthorship W1497172961A5053538919 @default.
• W1497172961 hasAuthorship W1497172961A5054404247 @default.
• W1497172961 hasAuthorship W1497172961A5056480184 @default.
• W1497172961 hasAuthorship W1497172961A5060108017 @default.
• W1497172961 hasBestOaLocation W14971729611 @default.
• W1497172961 hasConcept C126322002 @default.
• W1497172961 hasConcept C134018914 @default.
• W1497172961 hasConcept C2777180221 @default.

• next